Search Results - "Lipchik, Andrew M."

A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA by Van Bortle, Kevin, Marciano, David P., Liu, Qing, Chou, Tristan, Lipchik, Andrew M., Gollapudi, Sanjay, Geller, Benjamin S., Monte, Emma, Kamakaka, Rohinton T., Snyder, Michael P.

“…RNA polymerase III (Pol III) includes two alternate isoforms, defined by mutually exclusive incorporation of subunit POLR3G (RPC7α) or POLR3GL (RPC7β), in…”
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Time-Resolved Luminescence Detection of Spleen Tyrosine Kinase Activity through Terbium Sensitization by Lipchik, Andrew M, Parker, Laurie L

“…Disruption of regulatory protein phosphorylation can lead to disease and is particularly prevalent in cancers. Inhibitors that target deregulated kinases are…”
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Multicolored, Tb3+-Based Antibody-Free Detection of Multiple Tyrosine Kinase Activities by Lipchik, Andrew M, Perez, Minervo, Cui, Wei, Parker, Laurie L

“…Kinase signaling is a major mechanism driving many cancers. While many inhibitors have been developed and are employed in the clinic, resistance due to…”
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A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain by Gui, Junhong, Liu, Boyi, Cao, Guan, Lipchik, Andrew M., Perez, Minervo, Dekan, Zoltan, Mobli, Mehdi, Daly, Norelle L., Alewood, Paul F., Parker, Laurie L., King, Glenn F., Zhou, Yufeng, Jordt, Sven-Eric, Nitabach, Michael N.

“…The venoms of predators have been an excellent source of diverse highly specific peptides targeting ion channels. Here we describe the first known peptide…”
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Chromatin Remodeling in Response to BRCA2-Crisis by Gruber, Joshua J., Chen, Justin, Geller, Benjamin, Jäger, Natalie, Lipchik, Andrew M., Wang, Guangwen, Kurian, Allison W., Ford, James M., Snyder, Michael P.

“…Individuals with a single functional copy of the BRCA2 tumor suppressor have elevated risks for breast, ovarian, and other solid tumor malignancies. The exact…”
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HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding by Gruber, Joshua J., Geller, Benjamin, Lipchik, Andrew M., Chen, Justin, Salahudeen, Ameen A., Ram, Ashwin N., Ford, James M., Kuo, Calvin J., Snyder, Michael P.

“…The energetic costs of duplicating chromatin are large and therefore likely depend on nutrient sensing checkpoints and metabolic inputs. By studying chromatin…”
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Acetyl-Click Screening Platform Identifies Small-Molecule Inhibitors of Histone Acetyltransferase 1 (HAT1) by Gaddameedi, Jitender D., Chou, Tristan, Geller, Benjamin S., Rangarajan, Amithvikram, Swaminathan, Tarun A., Dixon, Danielle, Long, Katherine, Golder, Caiden J., Vuong, Van A., Banuelos, Selene, Greenhouse, Robert, Snyder, Michael P., Lipchik, Andrew M., Gruber, Joshua J.

“…HAT1 is a central regulator of chromatin synthesis that acetylates nascent histone H4. To ascertain whether targeting HAT1 is a viable anticancer treatment…”
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Substrate binding to Src: A new perspective on tyrosine kinase substrate recognition from NMR and molecular dynamics by Joshi, Mehul K., Burton, Robert A., Wu, Heng, Lipchik, Andrew M., Craddock, Barbara P., Mo, Huaping, Parker, Laurie L., Miller, W. Todd, Post, Carol Beth

“…Most signal transduction pathways in humans are regulated by protein kinases through phosphorylation of their protein substrates. Typical eukaryotic protein…”
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A Peptide-Based Biosensor Assay To Detect Intracellular Syk Kinase Activation and Inhibition by Lipchik, Andrew M, Killins, Renee L, Geahlen, Robert L, Parker, Laurie L

“…Spleen tyrosine kinase (Syk) has been implicated in a number of pathologies including cancer and rheumatoid arthritis and thus has been pursued as a novel…”
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A Quantitative Proteomics-Based Competition Binding Assay to Characterize pITAM–Protein Interactions by Hu, Lianghai, Yang, Li, Lipchik, Andrew M, Geahlen, Robert L, Parker, Laurie L, Tao, W. Andy

“…Characterization of ligand–protein binding is of crucial importance in drug discovery. Classical competition binding assays measure the binding of a labeled…”
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KINATEST-ID: A Pipeline To Develop Phosphorylation-Dependent Terbium Sensitizing Kinase Assays by Lipchik, Andrew M, Perez, Minervo, Bolton, Scott, Dumrongprechachan, Vasin, Ouellette, Steven B, Cui, Wei, Parker, Laurie L

“…Nonreceptor protein tyrosine kinases (NRTKs) are essential for cellular homeostasis and thus are a major focus of current drug discovery efforts. Peptide…”
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A peptide biosensor for detecting intracellular Abl kinase activity using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry by Placzek, Ekaterina A., Plebanek, Michael P., Lipchik, Andrew M., Kidd, Stephanie R., Parker, Laurie L.

“…Many cancers are characterized by changes in protein phosphorylation as a result of kinase dysregulation. Disruption of Abl kinase signaling through the…”
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Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores by Martin, Victoria A., Wang, Wen-Horng, Lipchik, Andrew M., Parker, Laurie L., He, Yantao, Zhang, Sheng, Zhang, Zhong-Yin, Geahlen, Robert L.

“…The engagement of antigen receptors on lymphocytes leads to the activation of phospholipase C-γ, the mobilization of intracellular calcium and the activation…”
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THU262 Improvement Of Pharmacokinetic Properties Of Vasoactive Intestinal Peptide Through Backbone Modifications by Al Najar, Mathew S, Lipchik, Andrew M

“…Disclosure: M.S. Al Najar: None. A.M. Lipchik: None. Vasoactive Intestinal Peptide (VIP) is a 28 amino acid neuropeptide hormone that is a part of the…”
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SAT053 Development Of A Novel Peptide-based Insulin Sensitizer Through Disruption Of Inositol Polyphosphate 5-Phosphatase K (SKIP) - p21-activated Kinase 1 (Pak1) Interactions by Kimbrough, Alyssa M, Dev Gaddameedi, Jitender, Lipchik, Andrew M

“…Disclosure: A.M. Kimbrough: None. J. Dev Gaddameedi: None. A.M. Lipchik: None. Type 2 diabetes (T2D) is a prominent, chronic metabolic disease that affects…”
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Multicolored, Tb^sup 3+^-Based Antibody-Free Detection of Multiple Tyrosine Kinase Activities by Lipchik, Andrew M, Perez, Minervo, Cui, Wei, Parker, Laurie L

“…Kinase signaling is a major mechanism driving many cancers. While many inhibitors have been developed and are employed in the clinic, resistance due to…”
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Multicolored, Tb 3+ -Based Antibody-Free Detection of Multiple Tyrosine Kinase Activities by Lipchik, Andrew M., Perez, Minervo, Cui, Wei, Parker, Laurie L.

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Multicolored, Tb super( 3+)-Based Antibody-Free Detection of Multiple Tyrosine Kinase Activities by Lipchik, Andrew M, Perez, Minervo, Cui, Wei, Parker, Laurie L

“…Kinase signaling is a major mechanism driving many cancers. While many inhibitors have been developed and are employed in the clinic, resistance due to…”
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Multi-colored, Tb3+-based antibody-free detection of multiple tyrosine kinase activities by Lipchik, Andrew M., Perez, Minervo, Cui, Wei, Parker, Laurie L.

“…Kinase signaling is a major mechanism driving many cancers. While many inhibitors have been developed and are employed in the clinic, resistance due to…”
Get full text

Time-Resolved Luminescence Detection of Syk Kinase Activity Through Terbium Sensitization by Lipchik, Andrew M., Parker, Laurie L.

“…Disruption of regulatory protein phosphorylation can lead to disease, and is particularly prevalent in cancers. Inhibitors that target deregulated kinases are…”
Get full text