Search Results - "Lipari, T"

Structural and Functional Analysis of HtrA1 and Its Subdomains by Eigenbrot, Charles, Ultsch, Mark, Lipari, Michael T., Moran, Paul, Lin, S. Jack, Ganesan, Rajkumar, Quan, Clifford, Tom, Jeffrey, Sandoval, Wendy, van Lookeren Campagne, Menno, Kirchhofer, Daniel

“…The homotrimeric human serine protease HtrA1 is homologous to bacterial HtrA proteases regarding the trypsin-like catalytic and PDZ domains but differs by the…”
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Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge by Maun, Henry R., Vij, Rajesh, Walters, Benjamin T., Morando, Ashley, Jackman, Janet K., Wu, Ping, Estevez, Alberto, Chen, Xiaocheng, Franke, Yvonne, Lipari, Michael T., Dennis, Mark S., Kirchhofer, Daniel, Ciferri, Claudio, Loyet, Kelly M., Yi, Tangsheng, Eigenbrot, Charles, Lazarus, Robert A., Koerber, James T.

“…Human β-tryptase, a tetrameric trypsin-like serine protease, is an important mediator of allergic inflammatory responses in asthma. Antibodies generally…”
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Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2 by Kirchhofer, Daniel, Peek, Mark, Lipari, Michael T., Billeci, Karen, Fan, Bin, Moran, Paul

“…Hepsin, a type II transmembrane serine protease, is highly upregulated in prostate cancer and promotes tumor progression and metastasis. We generated a soluble…”
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The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody by Ciferri, Claudio, Lipari, Michael T, Liang, Wei-Ching, Estevez, Alberto, Hang, Julie, Stawicki, Scott, Wu, Yan, Moran, Paul, Elliott, Mike, Eigenbrot, Charles, Katschke, Kenneth J, van Lookeren Campagne, Menno, Kirchhofer, Daniel

“…High temperature requirement A1 (HtrA1) is a trypsin-fold serine protease implicated in the progression of age-related macular degeneration (AMD). Our interest…”
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Structural insight into distinct mechanisms of protease inhibition by antibodies by Wu, Yan, Eigenbrot, Charles, Liang, Wei-Ching, Stawicki, Scott, Shia, Steven, Fan, Bin, Ganesan, Rajkumar, Lipari, Michael T, Kirchhofer, Daniel

“…To better understand how the relatively flat antigen-combining sites of antibodies interact with the concave shaped substrate-binding clefts of proteases, we…”
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Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist by Kirchhofer, Daniel, Lipari, Michael T, Santell, Lydia, Billeci, Karen L, Maun, Henry R, Sandoval, Wendy N, Moran, Paul, Ridgway, John, Eigenbrot, Charles, Lazarus, Robert A

“…Hepatocyte growth factor (HGF), the ligand for the receptor tyrosine kinase Met, is secreted as single chain pro-HGF that lacks signaling activity. Pro-HGF…”
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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma by Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng

“…Severe asthma patients with low type 2 inflammation derive less clinical benefit from therapies targeting type 2 cytokines and represent an unmet need. We show…”
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Structural and Functional Basis of the Serine Protease-like Hepatocyte Growth Factor β-Chain in Met Binding and Signaling by Kirchhofer, Daniel, Yao, Xiaoyi, Peek, Mark, Eigenbrot, Charles, Lipari, Michael T., Billeci, Karen L., Maun, Henry R., Moran, Paul, Santell, Lydia, Wiesmann, Christian, Lazarus, Robert A.

“…Hepatocyte growth factor (HGF), a plasminogen-related growth factor, is the ligand for Met, a receptor tyrosine kinase implicated in development, tissue…”
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The Tissue Factor Region That Interacts with Substrates Factor IX and Factor X by Kirchhofer, Daniel, Lipari, Michael T, Moran, Paul, Eigenbrot, Charles, Kelley, Robert F

“…The enzymatic activity of coagulation factor VIIa is controlled by its cellular cofactor tissue factor (TF). TF binds factor VIIa with high affinity and, in…”
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The Tissue Factor Region That Interacts with Factor Xa in the Activation of Factor VII by Kirchhofer, Daniel, Eigenbrot, Charles, Lipari, Michael T, Moran, Paul, Peek, Mark, Kelley, Robert F

“…Tissue factor is the cell membrane-anchored cofactor for factor VIIa and triggers the coagulation reactions. The initial step is the conversion of factor VII…”
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Furin-cleaved Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Active and Modulates Low Density Lipoprotein Receptor and Serum Cholesterol Levels by Lipari, Michael T., Li, Wei, Moran, Paul, Kong-Beltran, Monica, Sai, Tao, Lai, Joyce, Lin, S. Jack, Kolumam, Ganesh, Zavala-Solorio, Jose, Izrael-Tomasevic, Anita, Arnott, David, Wang, Jianyong, Peterson, Andrew S., Kirchhofer, Daniel

“…Proprotein convertase subtilisin/kexin 9 (PCSK9) regulates plasma LDL cholesterol levels by regulating the degradation of LDL receptors. Another proprotein…”
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Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product by FENDLY, B. M, WINGET, M, HUDZIAK, R. M, LIPARI, M. T, NAPIER, M. A, ULLRICH, A

“…High levels of expression of either the epidermal growth factor receptor or the receptor-like HER2/neu gene product p185HER2 have been observed in a variety of…”
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Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain by Ultsch, M., Li, W., Eigenbrot, C., Di Lello, P., Lipari, M.T., Gerhardy, S., AhYoung, A.P., Quinn, J., Franke, Y., Chen, Y., Kong Beltran, M., Peterson, A., Kirchhofer, D.

“…Proprotein convertase subtilisin/kexin 9 (PCSK9) is a key regulator of lipid metabolism by degrading liver LDL receptors. Structural studies have provided…”
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Platelet Glycoprotein IIb-IIIa Protein Antagonists from Snake Venoms: Evidence for a Family of Platelet-Aggregation Inhibitors by Dennis, Mark S., Henzel, William J., Pitti, Robert M., Lipari, Michael T., Napier, Mary A., Deisher, Theresa A., Bunting, Stuart, Lazarus, Robert A.

“…The purification, complete amino acid sequence, and biological activity are described for several homologous snake venom proteins that are platelet…”
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Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody by Ganesan, Rajkumar, Eigenbrot, Charles, Wu, Yan, Liang, Wei-Ching, Shia, Steven, Lipari, Michael T., Kirchhofer, Daniel

“…Recent structural studies have outlined the mechanism of protease inhibition by active site-directed antibodies. However, the molecular basis of allosteric…”
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Orally Active Fibrinogen Receptor Antagonists. 2. Amidoximes as Prodrugs of Amidines by Weller, Thomas, Alig, Leo, Beresini, Maureen, Blackburn, Brent, Bunting, Stuart, Hadváry, Paul, Hürzeler Müller, Marianne, Knopp, Dietmar, Levet-Trafit, Bernard, Lipari, M. Terry, Modi, Nishit B, Müller, Marcel, Refino, Canio J, Schmitt, Monique, Schönholzer, Peter, Weiss, Sabine, Steiner, Beat

“…The potent and selective GP IIb-IIIa antagonist lamifiban (1, Ro 44-9883) is currently in clinical development as an injectable antithrombotic agent for…”
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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma by Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng

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Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors by Brachmann, R, Lindquist, P B, Nagashima, M, Kohr, W, Lipari, T, Napier, M, Derynck, R

“…TGF-alpha and EGF are structurally related factors that bind to and induce tyrosine autophosphorylation of a common receptor. Proteolytic cleavage of the…”
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Proper glycosylation and phosphorylation of the type A natriuretic peptide receptor are required for hormone-stimulated guanylyl cyclase activity by KOLLER, K. J, LIPARI, M. T, GOEDDEL, D. V

“…The natriuretic peptide receptor type A (NPR-A) is a receptor-guanylyl cyclase whose cytoplasmic enzymatic activity is stimulated by atrial natriuretic peptide…”
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Similar Molecular Interactions of Factor VII and Factor VIIa with the Tissue Factor Region that Allosterically Regulates Enzyme Activity by Kelley, Robert F, Yang, Jihong, Eigenbrot, Charles, Moran, Paul, Peek, Mark, Lipari, Michael T, Kirchhofer, Daniel

“…Tissue factor (TF) binds the zymogen (VII) and activated (VIIa) forms of coagulation factor VII with high affinity. The structure determined for the sTF−VIIa…”
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