Search Results - "Liossis, Stamatis‐Nick"

The abnormal signaling of the B cell receptor and co-receptors of lupus B cells by Liossis, Stamatis-Nick C.

“…It is easily understood that studying the physiology and pathophysiology of the BCRtriggered cascade is of importance, particularly in such diseases as…”
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Biologics in SAPHO syndrome: A systematic review by Daoussis, Dimitrios, Konstantopoulou, Georgia, Kraniotis, Pantelis, Sakkas, Lazaros, Liossis, Stamatis-Nick

“…The SAPHO syndrome is a relatively rare clinical entity characterized by a wide range of dermatological and musculoskeletal manifestations. Biologics have been…”
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Intestinal Involvement in Systemic Sclerosis: A Clinical Review by Sakkas, Lazaros I., Simopoulou, Theodora, Daoussis, Dimitrios, Liossis, Stamatis-Nick, Potamianos, Spyros

“…Systemic sclerosis (SSc) is a chronic systemic disease characterized by microvasculopathy, autoantibodies, and extensive fibrosis. Intestinal involvement is…”
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Th1/17 cells, a subset of Th17 cells, are expanded in patients with active systemic lupus erythematosus by Tsanaktsi, Anastasia, Solomou, Elena E., Liossis, Stamatis-Nick C.

“…Skewed cytokine production characterizes T cells in Systemic Lupus Erythematosus (SLE). Among Th17 cells that are expanded in lupus, a subset (Th1/17) retains…”
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B cell depletion treatment decreases Th17 cells in patients with rheumatoid arthritis by Bounia, Constantina A., Liossis, Stamatis-Nick C.

“…We aimed to evaluate for any possible effects of treatment with rituximab (RTX) on the peripheral Th17 and Treg subpopulations in patients with rheumatoid…”
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Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity by Fousteri, Georgia, Liossis, Stamatis-Nick C, Battaglia, Manuela

“…Abstract PTPN22 is a protein tyrosine phosphatase expressed by the majority of cells belonging to the innate and adaptive immune systems. Polymorphisms in…”
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Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study by Daoussis, Dimitrios, Liossis, Stamatis-Nick C., Tsamandas, Athanassios C., Kalogeropoulou, Christina, Kazantzi, Alexandra, Sirinian, Chaido, Karampetsou, Maria, Yiannopoulos, Georgios, Andonopoulos, Andrew P.

“…Objective. To assess the efficacy of rituximab (RTX) in SSc. Methods. Fourteen patients with SSc were evaluated. Eight patients were randomized to receive two…”
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The Pathophysiologic Role of Monocytes and Macrophages in Systemic Lupus Erythematosus: A Reappraisal by Katsiari, Christina G., MD, PhD, Liossis, Stamatis-Nick C, Sfikakis, Petros P

“…Objectives To review current developments, regarding the pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus (SLE). Methods We…”
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New onset of lupus nephritis in two patients with SLE shortly after initiation of treatment with belimumab by Staveri, Chrysanthi, MD, Karokis, Dimitrios, MD, Liossis, Stamatis-Nick C., MD, PhD

“…Abstract Purpose Belimumab is currently approved for the treatment of patients with active SLE despite standard treatment. However, it has not been formally…”
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Pathogenesis of human systemic lupus erythematosus: recent advances by Crispín, José C, Liossis, Stamatis-Nick C, Kis-Toth, Katalin, Lieberman, Linda A, Kyttaris, Vasileios C, Juang, Yuang-Taung, Tsokos, George C

“…Systemic lupus erythematosus (SLE) is an autoimmune disease with manifestations derived from the involvement of multiple organs including the kidneys, joints,…”
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The Infectious Basis of ACPA-Positive Rheumatoid Arthritis by Sakkas, Lazaros I, Daoussis, Dimitrios, Liossis, Stamatis-Nick, Bogdanos, Dimitrios P

“…Rheumatoid arthritis (RA) is associated with HLA-DRB1 shared epitope (HLA-DRB1SE) and anti-citrullinated protein autoantibodies (ACPAs). ACPAs precedes the…”
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Decreased CD22 expression and intracellular signaling aberrations in B cells of patients with systemic sclerosis by Melissaropoulos, Konstantinos, Liossis, Stamatis-Nick

“…The objective of the study was to explore the phenotype and intracellular signaling events of B cells in patients with systemic sclerosis (SSc). Peripheral…”
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B Cell-Based Treatments in SLE: Past Experience and Current Directions by Liossis, Stamatis-Nick C., Staveri, Chrysanthi

“…Purpose of Review B cells have been targeted recently by novel therapeutic approaches in patients with SLE. In this review, we discuss recent data that have…”
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The role of platelets in autoimmunity, vasculopathy and fibrosis. Implications for systemic sclerosis by Ntelis, Konstantinos, M.D, Solomou, Elena E., M.D, Sakkas, Lazaros, MD, DM, PhD(UK), FRCP(UK), Liossis, Stamatis-Nick, M.D, Daoussis, Dimitrios, M.D

“…Abstract Introduction Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, autoimmunity and widespread dermal and visceral…”
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B cells tell scleroderma fibroblasts to produce collagen by Daoussis, Dimitrios, Liossis, Stamatis-Nick C

“…In fibrosis fibroblasts are activated and overproduce collagen in a process with unknown drivers and equally unknown brakes that recently implicated a novel…”
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Treatment modalities and drug survival in a systemic sclerosis real-life patient cohort by Panopoulos, S, Chatzidionysiou, Κ, Tektonidou, M G, Bournia, V K, Drosos, A A, Liossis, Stamatis-Nick C, Dimitroulas, T, Sakkas, L, Boumpas, D, Voulgari, P V, Daoussis, D, Thomas, K, Georgiopoulos, G, Vosvotekas, G, Garyfallos, Α, Sidiropoulos, P, Bertsias, G, Vassilopoulos, D, Sfikakis, P P

“…European data indicate that systemic sclerosis (SSc)-related death rates are increasing, thus raising concerns about SSc's optimal management. Herein, we…”
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Prevalence of comorbidities in systemic sclerosis versus rheumatoid arthritis: a comparative, multicenter, matched-cohort study by Panopoulos, Stylianos, Tektonidou, Maria, Drosos, Alexandros A, Liossis, Stamatis-Nick, Dimitroulas, Theodoros, Garyfallos, Alexandros, Sakkas, Lazaros, Boumpas, Dimitrios, Voulgari, Paraskevi V, Daoussis, Dimitrios, Thomas, Konstantinos, Georgiopoulos, Georgios, Vosvotekas, Georgios, Vassilopoulos, Dimitrios, Sfikakis, Petros P

“…Comorbidities are common in chronic systemic connective tissue diseases and are associated with adverse outcomes, increased morbidity and mortality. Although…”
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B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis by Daoussis, Dimitrios, Tsamandas, Athanassios, Antonopoulos, Ioannis, Filippopoulou, Alexandra, Papachristou, Dionysios J, Papachristou, Nicholaos I, Andonopoulos, Andrew P, Liossis, Stamatis-Nick

“…Rituximab (RTX) may favorably affect skin and lung fibrosis in patients with systemic sclerosis (SSc); however, the underlying molecular mechanisms remain…”
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Treatment of Systemic Sclerosis-Associated Calcinosis: A Case Report of Rituximab-Induced Regression of CREST-Related Calcinosis and Review of the Literature by Daoussis, Dimitrios, MD, Antonopoulos, Ioannis, MD, Liossis, Stamatis-Nick C., MD, Yiannopoulos, Georgios, MD, Andonopoulos, Andrew P., MD, FACP

“…Objectives Calcinosis is frequently encountered in patients with systemic sclerosis (SSc) and may be associated with significant morbidity. No treatment has…”
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Treatment of systemic sclerosis associated fibrotic manifestations: Current options and future directions by Daoussis, Dimitrios, Liossis, Stamatis-Nick

“…Systemic sclerosis (SSc) is a complicated multisystem disease which is characterized by the highest standardized mortality ratio among all systemic rheumatic…”
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