Search Results - "Linz, K"

Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development by Loryan, Irena, Hoppe, Edmund, Hansen, Klaus, Held, Felix, Kless, Achim, Linz, Klaus, Marossek, Virginia, Nolte, Bert, Ratcliffe, Paul, Saunders, Derek, Terlinden, Rolf, Wegert, Anita, Welbers, André, Will, Olaf, Hammarlund-Udenaes, Margareta

“…Drug induced phospholipidosis (PLD) may be observed in the preclinical phase of drug development and pose strategic questions. As lysosomes have a central role…”
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Neutral effects of the novel analgesic tapentadol on cardiac repolarization due to mixed ion channel inhibitory activities by Schneider, J., Jahnel, U., Linz, K.

“…Tapentadol is a novel analgesic with µ‐opioid receptor agonistic and norepinephrine reuptake inhibiting activities at submicromolar concentrations. Given that…”
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Frequency and Determinants of Spontaneous Conversion to Sinus Rhythm in Patients Presenting to the Emergency Department with Recent-onset Atrial Fibrillation: A Systematic Review by Pluymaekers, Nikki Aha, Hermans, Astrid Nl, Linz, Dominik K, Dudink, Elton Amp, Luermans, Justin Glm, Weijs, Bob, Vernooy, Kevin, Crijns, Harry Jgm

“…The exact frequency and clinical determinants of spontaneous conversion (SCV) in patients with symptomatic recent-onset AF are unclear. The aim of this…”
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Clinical determinants of early spontaneous conversion to sinus rhythm in patients with atrial fibrillation by Pluymaekers, N. A. H. A., Dudink, E. A. M. P., Weijs, B., Vernooy, K., Hartgerink, D. E. J., Jacobs, J. S., Erküner, Ö., Marcks, N. G. H. M., van Cauteren, Y. J. M., Dinh, T., ter Bekke, R. M. A., Sels, J. E. M. W., Delnoij, T. S. R., Geyik, Z., Driessen, R. G. H., Linz, D. K., den Uijl, D. W., Crijns, H. J. G. M., Luermans, J. G. L. M.

“…Background The current standard of care for acute atrial fibrillation (AF) focuses primarily on immediate restoration of sinus rhythm by cardioversion,…”
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Level of Binocular Pseudoaccommodation in Patients Implanted with an Apodised, Diffractive and Trifocal Multifocal Intraocular Lens by Kretz, F T A, Attia, M A S, Linz, K, Auffarth, G U

“…The aim of this study was to make an evaluation of the pseudoaccommodation span and clinical results after implantation of a diffractive, apodised and trifocal…”
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Implantation of a sulcus-fixated toric additive intraocular lens in a case of high astigmatism after a triple procedure by Linz, K, Auffarth, G U, Kretz, F T A

“…Residual refractive errors, especially high-grade astigmatism after penetrating keratoplasty, often lead to a significant loss of vision. If high anismetropia…”
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Refraction after Implantation of Multifocal and Presbyopia-Correcting Intraocular Lenses by Kretz, F T A, Linz, K, Mueller, M, Gerl, M, Koss, M J, Gerl, R H, Auffarth, G U

“…Nowadays, further developments in the field of intraocular lenses offer a higher level of spectacle independence for our patients. As light gets scattered on…”
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The ins and outs of physical activity monitoring: implications for atrial fibrillation management by Elliott, Adrian D, Middeldorp, Melissa E, Linz, Dominik K

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The aging heart: changes in the pharmacodynamic electrophysiological response to verapamil in aged rabbit hearts by Salameh, A, Dhein, S, Fleischmann, B, Grohe, C, Hescheler, J, Linz, K W, Meyer, R

“…The aim of this study was to investigate whether the L-type calcium current (I(Ca.L)) may be altered in aged hearts and whether the classical calcium…”
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Binocular Fluocinolone Acetonide Intravitreal Implant for Therapy-Resistant Diabetic Maculopathy by Linz, K, Auffarth, G U, Kretz, F T

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Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs by Schneider, Johannes, Hauser, Renate, Andreas, Jens-Otto, Linz, Klaus, Jahnel, Ulrich

“…The effects of drugs that inhibit human ether-a-go-go-related gene (HERG) related cardiac potassium channels on the variability of QT duration as a sign of…”
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Association between comorbidities and left and right atrial dysfunction in patients with paroxysmal atrial fibrillation: Analysis of AF-RISK by van Mourik, Manouk J.W., Artola Arita, Vicente, Lyon, Aurore, Lumens, Joost, De With, Ruben R., van Melle, Joost P., Schotten, Ulrich, Bekkers, Sebastiaan C.A.M., Crijns, Harry J.G.M., Van Gelder, Isabelle C., Rienstra, Michiel, Linz, Dominik K.

“…To identify the association between comorbidities and left atrial (LA) and right atrial (RA) function in patients with paroxysmal atrial fibrillation (AF)…”
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The Akoya pearl oyster shell as an archival monitor of lead exposure by MacFarlane, G.R., Markich, S.J., Linz, K., Gifford, S., Dunstan, R.H., O'Connor, W., Russell, R.A.

“…The Akoya pearl oyster ( Pinctada imbricata) was experimentally exposed to (a) constant levels of lead (Pb) at 180 μg L −1 for nine weeks, or (b) two short…”
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Emergency department cardioversion of acute atrial fibrillation by Pluymaekers, Nikki A H A, Linz, Dominik K, Rienstra, Michiel, van Gelder, Isabelle C, Crijns, Harry J G M

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Rapid modulation of L-type calcium current by acutely applied oestrogens in isolated cardiac myocytes from human, guinea-pig and rat by Meyer, R, Linz, K W, Surges, R, Meinardus, S, Vees, J, Hoffmann, A, Windholz, O, Grohé, C

“…Gender-based differences in cardiovascular mortality may be due to a cardio-protective effect of oestrogens on the myocardium. However, mRNA expression of…”
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Overexpression of the Sarcolemmal Calcium Pump in the Myocardium of Transgenic Rats by Hammes, Annette, Oberdorf-Maass, Silke, Rother, Tobias, Nething, Katja, Gollnick, Frank, Linz, Klaus W, Meyer, Rainer, Hu, Kai, Han, Hong, Gaudron, Peter, Ertl, Georg, Hoffmann, Sigrid, Ganten, Ursula, Vetter, Roland, Schuh, Kai, Benkwitz, Claudia, Zimmer, Hans G, Neyses, Ludwig

“…The plasma membrane calmodulin-dependent calcium ATPase (PMCA) is a calcium-extruding enzyme controlling Ca homeostasis in nonexcitable cells. However, its…”
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Control of L-type calcium current during the action potential of guinea-pig ventricular myocytes by Linz, Klaus W., Meyer, Rainer

“…During an action potential the L-type Ca 2+ current ( I Ca,L ) activates rapidly, then partially declines leading to a sustained inward current during the…”
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Profile and kinetics of L-type calcium current during the cardiac ventricular action potential compared in guinea-pigs, rats and rabbits by Linz, K W, Meyer, R

“…The substantial interspecies differences in mammalian cardiac action potentials (APs) are attributed primarily to variations in K+ currents. In a comparative…”
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Distribution of a Persistent Sodium Current Across the Ventricular Wall in Guinea Pigs by Sakmann, Bernhard F.A.S, Spindler, Anthony J, Bryant, Simon M, Linz, Klaus W, Noble, Denis

“…A tetrodotoxin-sensitive persistent sodium current, IpNa, was found in guinea pig ventricular myocytes by whole-cell patch clamping. This current was…”
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Opioid-type Respiratory Depressant Side Effects of Cebranopadol in Rats Are Limited by Its Nociceptin/Orphanin FQ Peptide Receptor Agonist Activity by Linz, Klaus, Schröder, Wolfgang, Frosch, Stefanie, Christoph, Thomas

“…Cebranopadol is a first-in-class analgesic with agonist activity at classic opioid peptide receptors and the nociceptin/orphanin FQ peptide receptor. The…”
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