Search Results - "Linville, Raleigh M."

Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior by Linville, Raleigh M., DeStefano, Jackson G., Sklar, Matt B., Xu, Zinnia, Farrell, Alanna M., Bogorad, Max I., Chu, Chengyan, Walczak, Piotr, Cheng, Linzhao, Mahairaki, Vasiliki, Whartenby, Katharine A., Calabresi, Peter A., Searson, Peter C.

“…Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly specialized brain microvascular endothelial cells, a major…”
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Benchmarking in vitro tissue-engineered blood-brain barrier models by DeStefano, Jackson G, Jamieson, John J, Linville, Raleigh M, Searson, Peter C

“…The blood-brain barrier (BBB) plays a key role in regulating transport into and out of the brain. With increasing interest in the role of the BBB in health and…”
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Tissue-engineered blood-brain barrier models via directed differentiation of human induced pluripotent stem cells by Grifno, Gabrielle N., Farrell, Alanna M., Linville, Raleigh M., Arevalo, Diego, Kim, Joo Ho, Gu, Luo, Searson, Peter C.

“…Three-dimensional (3D) tissue-engineered models of the blood-brain barrier (BBB) recapitulate in vivo shear stress, cylindrical geometry, and cell-ECM…”
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Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D by Jamieson, John J, Linville, Raleigh M, Ding, Yuan Yuan, Gerecht, Sharon, Searson, Peter C

“…Pericytes of the blood-brain barrier (BBB) are embedded within basement membrane between brain microvascular endothelial cells (BMECs) and astrocyte end-feet…”
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Next-generation in vitro blood-brain barrier models: benchmarking and improving model accuracy by Linville, Raleigh M, Searson, Peter C

“…With the limitations associated with post-mortem tissue and animal models, In vitro BBB models enable precise control of independent variables and…”
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Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation by Katt, Moriah E, Linville, Raleigh M, Mayo, Lakyn N, Xu, Zinnia S, Searson, Peter C

“…Transwell-based models of the blood-brain barrier (BBB) incorporating monolayers of human brain microvascular endothelial cells (dhBMECs) derived from induced…”
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The influence of physiological and pathological perturbations on blood-brain barrier function by Zhao, Nan, Chung, Tracy D, Guo, Zhaobin, Jamieson, John J, Liang, Lily, Linville, Raleigh M, Pessell, Alex F, Wang, Linus, Searson, Peter C

“…The blood-brain barrier (BBB) is located at the interface between the vascular system and the brain parenchyma, and is responsible for communication with…”
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Corrigendum: The influence of physiological and pathological perturbations on blood-brain barrier function by Zhao, Nan, Chung, Tracy D, Guo, Zhaobin, Jamieson, John J, Liang, Lily, Linville, Raleigh M, Pessell, Alex F, Wang, Linus, Searson, Peter C

“…[This corrects the article DOI: 10.3389/fnins.2023.1289894.]…”
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Effects of acute and chronic oxidative stress on the blood-brain barrier in 2D and 3D in vitro models by Chung, Tracy D, Linville, Raleigh M, Guo, Zhaobin, Ye, Robert, Jha, Ria, Grifno, Gabrielle N, Searson, Peter C

“…Oxidative stress is a shared pathology of neurodegenerative disease and brain injuries, and is derived from perturbations to normal cell processes by aging or…”
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A tissue-engineered model of the blood-tumor barrier during metastatic breast cancer by Linville, Raleigh M, Maressa, Joanna, Guo, Zhaobin, Chung, Tracy D, Farrell, Alanna, Jha, Ria, Searson, Peter C

“…Metastatic brain cancer has poor prognosis due to challenges in both detection and treatment. One contributor to poor prognosis is the blood-brain barrier…”
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Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington's disease by Linville, Raleigh M, Nerenberg, Renée F, Grifno, Gabrielle, Arevalo, Diego, Guo, Zhaobin, Searson, Peter C

“…Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion of cytosine-adenine-guanine (CAG) repeats in the huntingtin gene, which…”
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Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels by Linville, Raleigh M, Sklar, Matthew B, Grifno, Gabrielle N, Nerenberg, Renée F, Zhou, Justin, Ye, Robert, DeStefano, Jackson G, Guo, Zhaobin, Jha, Ria, Jamieson, John J, Zhao, Nan, Searson, Peter C

“…The blood-brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are connected by…”
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Visualization of the Dynamics of Invasion and Intravasation of the Bacterium That Causes Lyme Disease in a Tissue Engineered Dermal Microvessel Model by Guo, Zhaobin, Zhao, Nan, Chung, Tracy D., Singh, Anjan, Pandey, Ikshu, Wang, Linus, Gu, Xinyue, Ademola, Aisha, Linville, Raleigh M., Pal, Utpal, Dumler, J. Stephen, Searson, Peter C.

“…Lyme disease is a tick‐borne disease prevalent in North America, Europe, and Asia. Despite the accumulated knowledge from epidemiological, in vitro, and in…”
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A Tissue-Engineered 3D Microvessel Model Reveals the Dynamics of Mosaic Vessel Formation in Breast Cancer by Silvestri, Vanesa L, Henriet, Elodie, Linville, Raleigh M, Wong, Andrew D, Searson, Peter C, Ewald, Andrew J

“…In solid tumors, vascular structure and function varies from the core to the periphery. This structural heterogeneity has been proposed to influence the…”
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Modeling hyperosmotic blood–brain barrier opening within human tissue-engineered in vitro brain microvessels by Linville, Raleigh M, DeStefano, Jackson G, Sklar, Matt B, Chu, Chengyan, Walczak, Piotr, Searson, Peter C

“…As the majority of therapeutic agents do not cross the blood–brain barrier (BBB), transient BBB opening (BBBO) is one strategy to enable delivery into the…”
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Reversible blood-brain barrier opening utilizing the membrane active peptide melittin in vitro and in vivo by Linville, Raleigh M., Komin, Alexander, Lan, Xiaoyan, DeStefano, Jackson G., Chu, Chengyan, Liu, Guanshu, Walczak, Piotr, Hristova, Kalina, Searson, Peter C.

“…The blood-brain barrier (BBB) tightly controls entry of molecules and cells into the brain, restricting the delivery of therapeutics. Blood-brain barrier…”
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Cerebrovascular plasticity: Processes that lead to changes in the architecture of brain microvessels by Bogorad, Max I, DeStefano, Jackson G, Linville, Raleigh M, Wong, Andrew D, Searson, Peter C

“…The metabolic demands of the brain are met by oxygen and glucose, supplied by a complex hierarchical network of microvessels (arterioles, capillaries, and…”
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Engineering the Human Blood–Brain Barrier at the Capillary Scale using a Double‐Templating Technique by Zhao, Nan, Guo, Zhaobin, Kulkarni, Sarah, Norman, Danielle, Zhang, Sophia, Chung, Tracy D., Nerenberg, Renée F., Linville, Raleigh M., Searson, Peter

“…In vitro blood–brain barrier (BBB) models have played an important role in studying processes such as immune cell trafficking and drug delivery, as well as…”
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Three-dimensional induced pluripotent stem-cell models of human brain angiogenesis by Linville, Raleigh M., Arevalo, Diego, Maressa, Joanna C., Zhao, Nan, Searson, Peter C.

“…During brain development, chemical cues released by developing neurons, cellular signaling with pericytes, and mechanical cues within the brain extracellular…”
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Comparison of blind deconvolution- and Patlak analysis-based methods for determining vascular permeability by Tien, Joe, Li, Xuanyue, Linville, Raleigh M., Feldman, Evan J.

“…This study describes a computational algorithm to determine vascular permeability constants from time-lapse imaging data without concurrent knowledge of the…”
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