Search Results - "Linusson, A"

Statistical molecular design of balanced compound libraries for QSAR modeling by Linusson, A, Elofsson, M, Andersson, I E, Dahlgren, M K

“…A fundamental step in preclinical drug development is the computation of quantitative structure-activity relationship (QSAR) models, i.e. models that link…”
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On the use of electronic descriptors for QSAR modelling of PCDDs, PCDFs and dioxin-like PCBs by Larsson, M., Kumar Mishra, B., Tysklind, M., Linusson, A., Andersson, P. L.

“…The electronic properties of 29 polychlorinated dibenzo-p-dioxins and dibenzofurans and dioxin-like polychlorinated biphenyls that have been included in the…”
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Statistical Molecular Design, Parallel Synthesis, and Biological Evaluation of a Library of Thrombin Inhibitors by Linusson, Anna, Gottfries, Johan, Olsson, Thomas, Örnskov, Eivor, Folestad, Staffan, Nordén, Bo, Wold, Svante

“…A library of thrombin inhibitors has been designed using statistical molecular design. An aromatic scaffold was used, with three varied positions corresponding…”
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Reduced community diversity in semi-natural meadows in southern Sweden, 1965-1990 by Linusson, A.C, Berlin, G.A.I, Olsson, E.G.A

“…Two data sets, one from the 1960s and one from 1990, from continuously managed semi-natural meadows (semi-natural grasslands used for hay-cutting) in Småland,…”
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Vegetation changes in semi-natural meadows with unchanged management in southern Sweden, 1965–1990 by Berlin, Gudrun A.I., Linusson, Anna-Carin, Olsson, E.Gunilla A.

“…Vegetation records from 1963–66 and 1990 were compared in eight semi-permanent plots from continuously managed, semi-natural hay-meadows from five sites in…”
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Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases by Minina, Elena A., Staal, Jens, Alvarez, Vanina E., Berges, John A., Berman-Frank, Ilana, Beyaert, Rudi, Bidle, Kay D., Bornancin, Frédéric, Casanova, Magali, Cazzulo, Juan J., Choi, Chang Jae, Coll, Nuria S., Dixit, Vishva M., Dolinar, Marko, Fasel, Nicolas, Funk, Christiane, Gallois, Patrick, Gevaert, Kris, Gutierrez-Beltran, Emilio, Hailfinger, Stephan, Klemenčič, Marina, Koonin, Eugene V., Krappmann, Daniel, Linusson, Anna, Machado, Maurício F.M., Madeo, Frank, Megeney, Lynn A., Moschou, Panagiotis N., Mottram, Jeremy C., Nyström, Thomas, Osiewacz, Heinz D., Overall, Christopher M., Pandey, Kailash C., Ruland, Jürgen, Salvesen, Guy S., Shi, Yigong, Smertenko, Andrei, Stael, Simon, Ståhlberg, Jerry, Suárez, María Fernanda, Thome, Margot, Tuominen, Hannele, Van Breusegem, Frank, van der Hoorn, Renier A.L., Vardi, Assaf, Zhivotovsky, Boris, Lam, Eric, Bozhkov, Peter V.

“…Metacaspases and paracaspases are proteases that were first identified as containing a caspase-like structural fold ( Uren et al., 2000 ). Like caspases, meta-…”
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Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein by Karlberg, Tobias, Klepsch, Mirjam, Thorsell, Ann-Gerd, Andersson, C. David, Linusson, Anna, Schüler, Herwig

“…The mammalian poly(ADP-ribose) polymerase (PARP) family includes ADP-ribosyltransferases with diphtheria toxin homology (ARTD). Most members have…”
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SHOP:  Scaffold HOPping by GRID-Based Similarity Searches by Bergmann, Rikke, Linusson, Anna, Zamora, Ismael

“…A new GRID-based method for scaffold hopping (SHOP) is presented. In a fully automatic manner, scaffolds were identified in a database based on three types of…”
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Towards small molecule inhibitors of mono-ADP-ribosyltransferases by Ekblad, Torun, Lindgren, Anders E.G., Andersson, C. David, Caraballo, Rémi, Thorsell, Ann-Gerd, Karlberg, Tobias, Spjut, Sara, Linusson, Anna, Schüler, Herwig, Elofsson, Mikael

“…Protein ADP-ribosylation is a post-translational modification involved in DNA repair, protein degradation, transcription regulation, and epigenetic events…”
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Dynamics Determine Signaling in a Multicomponent System Associated with Rheumatoid Arthritis by Lindgren, Cecilia, Tyagi, Mohit, Viljanen, Johan, Toms, Johannes, Ge, Changrong, Zhang, Naru, Holmdahl, Rikard, Kihlberg, Jan, Linusson, Anna

“…Strategies that target multiple components are usually required for treatment of diseases originating from complex biological systems. The multicomponent…”
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PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3 by Lindgren, Anders E. G, Karlberg, Tobias, Thorsell, Ann-Gerd, Hesse, Mareike, Spjut, Sara, Ekblad, Torun, Andersson, C. David, Pinto, Ana Filipa, Weigelt, Johan, Hottiger, Michael O, Linusson, Anna, Elofsson, Mikael, Schüler, Herwig

“…Inhibiting ADP-ribosyl transferases with PARP-inhibitors is considered a promising strategy for the treatment of many cancers and ischemia, but most of the…”
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Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening by Andersson, C. David, Karlberg, Tobias, Ekblad, Torun, Lindgren, Anders E. G, Thorsell, Ann-Gerd, Spjut, Sara, Uciechowska, Urszula, Niemiec, Moritz S, Wittung-Stafshede, Pernilla, Weigelt, Johan, Elofsson, Mikael, Schüler, Herwig, Linusson, Anna

“…The diphtheria toxin-like ADP-ribosyltransferases (ARTDs) are an enzyme family that catalyzes the transfer of ADP-ribose units onto substrate proteins by using…”
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Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes by Lindgren, Cecilia, Andersson, Ida E, Berg, Lotta, Dobritzsch, Doreen, Ge, Changrong, Haag, Sabrina, Uciechowska, Urszula, Holmdahl, Rikard, Kihlberg, Jan, Linusson, Anna

“…Class II major histocompatibility complex (MHC) proteins are involved in initiation of immune responses to foreign antigens via presentation of peptides to…”
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Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3 by Lindgren, Anders E. G, Karlberg, Tobias, Ekblad, Torun, Spjut, Sara, Thorsell, Ann-Gerd, Andersson, C. David, Nhan, Ton Tong, Hellsten, Victor, Weigelt, Johan, Linusson, Anna, Schüler, Herwig, Elofsson, Mikael

“…The racemic 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[1-(pyridin-2-yl)­ethyl]­propanamide, 1, has previously been identified as a potent but unselective…”
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(E)-alkene and ethylene isosteres substantially alter the hydrogen-bonding network in class II MHC A(q)/glycopeptide complexes and affect T-cell recognition by Andersson, Ida E, Batsalova, Tsvetelina, Haag, Sabrina, Dzhambazov, Balik, Holmdahl, Rikard, Kihlberg, Jan, Linusson, Anna

“…The structural basis for antigen presentation by class II major histocompatibility complex (MHC) proteins to CD4(+) T-cells is important for understanding and…”
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Oxazole-modified glycopeptides that target arthritis-associated class II MHC A(q) and DR4 proteins by Andersson, Ida E, Batsalova, Tsvetelina, Dzhambazov, Balik, Edvinsson, Lotta, Holmdahl, Rikard, Kihlberg, Jan, Linusson, Anna

“…The glycopeptide CII259-273, a fragment from type II collagen (CII), can induce tolerance in mice susceptible to collagen-induced arthritis (CIA), which is a…”
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A multivariate chemical map of industrial chemicals – Assessment of various protocols for identification of chemicals of potential concern by Stenberg, Mia, Linusson, Anna, Tysklind, Mats, Andersson, Patrik L.

“…In present study the Industrial chemical map was created, and investigated. Molecular descriptors were calculated for 56 072 organic substances from the…”
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Design of glycopeptides used to investigate class II MHC binding and T-cell responses associated with autoimmune arthritis by Andersson, Ida E, Andersson, C David, Batsalova, Tsvetelina, Dzhambazov, Balik, Holmdahl, Rikard, Kihlberg, Jan, Linusson, Anna

“…The glycopeptide fragment CII259-273 from type II collagen (CII) binds to the murine A(q) and human DR4 class II Major Histocompatibility Complex (MHC II)…”
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Determination of dissociation constants of labile drug compounds by capillary electrophoresis by Örnskov, Eivor, Linusson, Anna, Folestad, Staffan

“…The utility of capillary electrophoresis (CE) for determination of the negative logarithm of dissociation constants (p K a) of labile compounds was…”
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( E )-Alkene and Ethylene Isosteres Substantially Alter the Hydrogen-Bonding Network in Class II MHC A q /Glycopeptide Complexes and Affect T-Cell Recognition by Andersson, Ida E., Batsalova, Tsvetelina, Haag, Sabrina, Dzhambazov, Balik, Holmdahl, Rikard, Kihlberg, Jan, Linusson, Anna

“…The structural basis for antigen presentation by class II major histocompatibility complex (MHC) proteins to CD4(+) T-cells is important for understanding and…”
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