Search Results - "Linterman, Michelle"

Age-dependent changes in T follicular helper cells shape the humoral immune response to vaccination by Linterman, Michelle A.

“…Vaccination is an excellent strategy to limit the morbidity and mortality associated with infectious disease. Vaccination creates protective, long-lived…”
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Mechanisms underpinning poor antibody responses to vaccines in ageing by Lee, Jia Le, Linterman, Michelle A

“…•Older people are more susceptible to poor health outcomes after infection.•Ageing is associated with reduced antibody titres in response to vaccination,…”
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ZFP318 fuels memory B cells for success by Salerno, Fiamma, Linterman, Michelle A

“…Diversity is a key feature of B cell biology-from BCR rearrangement to the heterogeneity of memory B cells. In this issue of Immunity, Wang et al. show that…”
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Regulation of the Germinal Center Response by Stebegg, Marisa, Kumar, Saumya D, Silva-Cayetano, Alyssa, Fonseca, Valter R, Linterman, Michelle A, Graca, Luis

“…The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and…”
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Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells by Aloulou, Meryem, Carr, Edward J., Gador, Mylène, Bignon, Alexandre, Liblau, Roland S., Fazilleau, Nicolas, Linterman, Michelle A.

“…T follicular regulatory (Tfr) cells are a subset of Foxp3 + regulatory T (Treg) cells that form in response to immunization or infection, which localize to the…”
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Follicular Helper T Cells by Vinuesa, Carola G, Linterman, Michelle A, Yu, Di, MacLennan, Ian C.M

“…Although T cell help for B cells was described several decades ago, it was the identification of CXCR5 expression by B follicular helper T (Tfh) cells and the…”
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Cbls boost B cells by Linterman, Michelle A

“…T cell regulation of antibody-mediated immunity is critical for health. In this issue of JEM, Li et al. (https://doi.org/10.1084/jem.20191537) identify the Cbl…”
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CD4+ T cells that help B cells – a proposal for uniform nomenclature by Eisenbarth, Stephanie C., Baumjohann, Dirk, Craft, Joe, Fazilleau, Nicolas, Ma, Cindy S., Tangye, Stuart G., Vinuesa, Carola G., Linterman, Michelle A.

“…T follicular helper (Tfh) cells cognately guide differentiation of antigen-primed B cells in secondary lymphoid tissues. ‘Tfh-like’ populations not expressing…”
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Shaping Variation in the Human Immune System by Liston, Adrian, Carr, Edward J, Linterman, Michelle A

“…Immune responses demonstrate a high level of intra-species variation, compensating for the specialization capacity of pathogens. The recent advent of in-depth…”
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Stromal cell control of conventional and ectopic germinal centre reactions by Silva-Cayetano, Alyssa, Linterman, Michelle A

“…• Stromal cells support the initiation, maintenance and output of germinal centre responses.• Fibroblasts are key mediators of tertiary lymphoid structure…”
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How T follicular helper cells and the germinal centre response change with age by Linterman, Michelle A

“…Normal ageing is accompanied by a decline in the function of the immune system that causes an increased susceptibility to infections and an impaired response…”
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Targeting TFH cells in human diseases and vaccination: rationale and practice by Yu, Di, Walker, Lucy S. K., Liu, Zheng, Linterman, Michelle A., Li, Zhanguo

“…The identification of CD4 + T cells localizing to B cell follicles has revolutionized the knowledge of how humoral immunity is generated. Follicular helper T…”
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Follicular regulatory T cells produce neuritin to regulate B cells by Gonzalez-Figueroa, Paula, Roco, Jonathan A., Papa, Ilenia, Núñez Villacís, Lorena, Stanley, Maurice, Linterman, Michelle A., Dent, Alexander, Canete, Pablo F., Vinuesa, Carola G.

“…Regulatory T cells prevent the emergence of autoantibodies and excessive IgE, but the precise mechanisms are unclear. Here, we show that BCL6-expressing Tregs,…”
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The cellular composition of the human immune system is shaped by age and cohabitation by Carr, Edward J, Dooley, James, Garcia-Perez, Josselyn E, Lagou, Vasiliki, Lee, James C, Wouters, Carine, Meyts, Isabelle, Goris, An, Boeckxstaens, Guy, Linterman, Michelle A, Liston, Adrian

“…Using a systems-biology approach, Liston and colleagues profile the immune system of 670 healthy volunteers to provide a description of the population-level…”
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The dark side of Tregs during aging by Palatella, Martina, Guillaume, Stephane M, Linterman, Michelle A, Huehn, Jochen

“…In the last century, we have seen a dramatic rise in the number of older persons globally, a trend known as the grey (or silver) tsunami. People live markedly…”
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Type I interferon induces CXCL13 to support ectopic germinal center formation by Denton, Alice E, Innocentin, Silvia, Carr, Edward J, Bradford, Barry M, Lafouresse, Fanny, Mabbott, Neil A, Mörbe, Urs, Ludewig, Burkhard, Groom, Joanna R, Good-Jacobson, Kim L, Linterman, Michelle A

“…Ectopic lymphoid structures form in a wide range of inflammatory conditions, including infection, autoimmune disease, and cancer. In the context of infection,…”
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Heterochronic faecal transplantation boosts gut germinal centres in aged mice by Stebegg, Marisa, Silva-Cayetano, Alyssa, Innocentin, Silvia, Jenkins, Timothy P., Cantacessi, Cinzia, Gilbert, Colin, Linterman, Michelle A.

“…Ageing is a complex multifactorial process associated with a plethora of disorders, which contribute significantly to morbidity worldwide. One of the organs…”
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Highlight of 2023: Advances in germinal centers by Pankhurst, Theresa E, Linterman, Michelle A

“…In this article for the Highlight of 2023 series, we discuss recent advances in the fundamental biology of the germinal center response. These discoveries…”
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Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8⁺ T cells by Denton, Alice E., Roberts, Edward W., Linterman, Michelle A., Fearon, Douglas T.

“…Fibroblastic reticular cells (FRCs), through their expression of CC chemokine ligand (CCL)19 and CCL21, attract and retain T cells in lymph nodes (LNs), but…”
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MicroRNA regulation of T-cell development by Dooley, James, Linterman, Michelle A., Liston, Adrian

“…Summary MicroRNAs are short, 19–24 nucleotide long, RNA molecules capable of regulating the longevity and, to a lesser extent, translation of messenger RNA…”
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