Search Results - "Lintas, Valentina"
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Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity
Published in Nature reviews cardiology (01-02-2021)“…Valvular heart disease is a major cause of morbidity and mortality worldwide. Surgical valve repair or replacement has been the standard of care for patients…”
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Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo
Published in Scientific reports (16-11-2020)“…Regenerative tissue-engineered matrix-based heart valves (TEM-based TEHVs) may become an alternative to currently-used bioprostheses for transcatheter valve…”
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Endothelial Progenitor Cell-Based in vitro Pre-Endothelialization of Human Cell-Derived Biomimetic Regenerative Matrices for Next-Generation Transcatheter Heart Valves Applications
Published in Frontiers in bioengineering and biotechnology (31-03-2022)“…Hemocompatibility of cardiovascular implants represents a major clinical challenge and, to date, optimal antithrombotic properties are lacking. Next-generation…”
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Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements
Published in JACC. Basic to translational science (01-01-2020)“…[Display omitted] •Bone marrow mononuclear cell pre-seeding of polycarbonate bisurea–based tissue-engineered heart valves has detrimental effects on long-term…”
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In situ heart valve tissue engineering using a bioresorbable elastomeric implant – From material design to 12 months follow-up in sheep
Published in Biomaterials (01-05-2017)“…Abstract The creation of a living heart valve is a much-wanted alternative for current valve prostheses that suffer from limited durability and thromboembolic…”
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TCT-795 Human cell derived off-the-shelf Tissue Engineered Heart Valves for next generation Transcatheter Aortic Valve Replacement: a proof-of-concept study in adult sheep
Published in Journal of the American College of Cardiology (31-10-2017)“…Transcatheter based tissue engineered heart valves (TEHVs) may overcome these limitations and may thus represent a next generation transcatheter aortic valve…”
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Off-the-shelf tissue engineered heart valves for in situ regeneration: current state, challenges and future directions
Published in Expert review of medical devices (02-01-2018)“…Transcatheter aortic valve replacement (TAVR) is continuously evolving and is expected to surpass surgical valve implantation in the near future. Combining…”
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Development of an Off-the-Shelf Tissue-Engineered Sinus Valve for Transcatheter Pulmonary Valve Replacement: a Proof-of-Concept Study
Published in Journal of cardiovascular translational research (01-06-2018)“…Tissue-engineered heart valves with self-repair and regeneration properties may overcome the problem of long-term degeneration of currently used artificial…”
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Human cell-derived tissue-engineered heart valve with integrated Valsalva sinuses: towards native-like transcatheter pulmonary valve replacements
Published in npj Regenerative medicine (17-06-2019)“…Transcatheter valve replacement indication is currently being extended to younger and lower-risk patients. However, transcatheter prostheses are still based on…”
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Can finite element models of ballooning procedures yield mechanical response of the cardiovascular site to overexpansion?
Published in Journal of biomechanics (06-09-2016)“…Abstract Patient-specific numerical models could aid the decision-making process for percutaneous valve selection; in order to be fully informative, they…”
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Numerical model of a valvuloplasty balloon: in vitro validation in a rapid-prototyped phantom
Published in Biomedical engineering online (12-04-2016)“…Patient-specific simulations can provide insight into the mechanics of cardiovascular procedures. Amongst cardiovascular devices, non-compliant balloons are…”
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