Search Results - "Linossi, Constanza"

Landscape of innate and adaptive immunity targets in oesophagogastric adenocarcinoma (OGA) by Smyth, Elizabeth Catherine, Linossi, Constanza, Jammula, Sriganesh, Devonshire, Ginny, Fitzgerald, Rebecca C.

“…Abstract only 4063 Background: Anti-PD-1 therapy modestly improves survival in chemorefractory OGA. Combining PD-1 blockade with novel checkpoint inhibitors,…”
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First-in-Human Phase I Study of MP0250, a First-in-Class DARPin Drug Candidate Targeting VEGF and HGF, in Patients With Advanced Solid Tumors by Baird, Richard D, Linossi, Constanza, Middleton, Mark, Lord, Simon, Harris, Adrian, Rodón, Jordi, Zitt, Christof, Fiedler, Ulrike, Dawson, Keith M, Leupin, Nicolas, Stumpp, Michael T, Harstrick, Andreas, Azaro, Analía, Fischer, Stefanie, Omlin, Aurelius

“…A first-in-human study was performed with MP0250, a DARPin drug candidate. MP0250 specifically inhibits both vascular endothelial growth factor (VEGF) and…”
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POSEIDON Trial Phase 1b Results: Safety, Efficacy and Circulating Tumor DNA Response of the Beta Isoform-Sparing PI3K Inhibitor Taselisib (GDC-0032) Combined with Tamoxifen in Hormone Receptor Positive Metastatic Breast Cancer Patients by Baird, Richard D, van Rossum, Annelot G J, Oliveira, Mafalda, Beelen, Karin, Gao, Meiling, Schrier, Mariette, Mandjes, Ingrid A M, Garcia-Corbacho, Javier, Vallier, Anne-Laure, Dougall, Greig, van Werkhoven, Erik, Linossi, Constanza, Kumar, Sanjeev, van Tinteren, Harm, Callari, Maurizio, Beddowes, Emma, Perez-Garcia, José-Manuel, Rosing, Hilde, Platte, Else, Nederlof, Petra, Schot, Margaret, de Vries Schultink, Aurelia, Bernards, René, Saura, Cristina, Gallagher, William, Cortès, Javier, Caldas, Carlos, Linn, Sabine C

“…The strategy of combining endocrine therapy with PI3K-mTOR inhibition has shown promise in estrogen receptor (ER)-positive breast cancer, but new agents and…”
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Cambridge Brain Mets Trial 1 (CamBMT1): A proof of principle study of afatinib penetration into cerebral metastases (mets) for patients (pts) undergoing neurosurgical resection, combined with low-dose, targeted radiotherapy (RT)—Phase 1b results by Baird, Richard D., Garcia-Corbacho, Javier, Linossi, Constanza, Kumar, Sanjeev Srinivas, Smith, Donna, Williams, Michael, Qian, Wendi, Machin, Andrea, Ahmad, Saif, Matys, Tomasz, Jena, Raj, Pacey, Simon, Caldas, Carlos, Jodrell, Duncan Ian, Jefferies, Sarah, Price, Stephen, Watts, Colin, Ramenatte, Nicola

“…Abstract only 2008 Background: Failure of drugs to cross the blood brain barrier (BBB) can be a major reason for treatment failure in pts with brain tumours…”
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