Search Results - "Lino, J."

Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia by Tong, Stephen, Kaitu’u-Lino, Tu’uhevaha J., Hastie, Roxanne, Brownfoot, Fiona, Cluver, Catherine, Hannan, Natalie

“…There has been increasing research momentum to identify new therapeutic agents for the prevention or treatment of preeclampsia, drugs that can affect the…”
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Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction by Brownfoot, Fiona C., MBBS, Hastie, Roxanne, BBiomed Sc, Hannan, Natalie J., B Sci, PhD, Cannon, Ping, B Sci, Tuohey, Laura, BSci, Parry, Laura J., B Sci, PhD, Senadheera, Sevvandi, B Sci PhD, Illanes, Sebastian E., MBBS, MSc, Kaitu’u-Lino, Tu’uhevaha J., PhD, Tong, Stephen, MBBS, PhD

“…Background Preeclampsia is associated with placental ischemia/hypoxia and secretion of soluble fms-like tyrosine kinase 1 and soluble endoglin into the…”
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Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe Preeclampsia by Brownfoot, Fiona C, Tong, Stephen, Hannan, Natalie J, Binder, Natalie K, Walker, Susan P, Cannon, Ping, Hastie, Roxanne, Onda, Kenji, Kaitu’u-Lino, Tu’uhevaha J

“…Preeclampsia is a major pregnancy complication where excess placental release of soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin causes…”
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Using the methylome to predict pre-eclampsia by Kaitu’u-Lino, Tu’uhevaha J., Bartho, Lucy A., Tong, Stephen

“…A blood test done in early pregnancy that measures cell-free DNA methylation could represent a novel way to predict the risk of preterm pre-eclampsia…”
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Quantitative Point of Care Tests for Timely Diagnosis of Early‐Onset Preeclampsia with High Sensitivity and Specificity by Masoumeh Ghorbanpour, Sahar, Wen, Shihui, Kaitu'u‐Lino, Tu'uhevaha J, Hannan, Natalie J., Jin, Dayong, McClements, Lana

“…Preeclampsia is a heterogeneous and multiorgan cardiovascular disorder of pregnancy. Here, we report the development of a novel strip‐based lateral flow assay…”
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Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia by Hannan, Natalie J, Binder, Natalie K, Beard, Sally, Nguyen, Tuong-Vi, Kaitu'u-Lino, Tu'uhevaha J, Tong, Stephen

“…Preeclampsia is one of the most serious complications of pregnancy. Currently there are no medical treatments. Given placental oxidative stress may be an early…”
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Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia by Kaitu'u-Lino, Tu'uhevaha J, Brownfoot, Fiona C, Beard, Sally, Cannon, Ping, Hastie, Roxanne, Nguyen, Tuong V, Binder, Natalie K, Tong, Stephen, Hannan, Natalie J

“…The discovery of new treatments that prevent or treat preeclampsia would be a major advance. Antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1)…”
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EGFR (Epidermal Growth Factor Receptor) Signaling and the Mitochondria Regulate sFlt-1 (Soluble FMS-Like Tyrosine Kinase-1) Secretion by Hastie, Roxanne, Brownfoot, Fiona C, Pritchard, Natasha, Hannan, Natalie J, Cannon, Ping, Nguyen, Vi, Palmer, Kirsten, Beard, Sally, Tong, Stephen, Kaitu’u-Lino, Tu’uhevaha J

“…Preeclampsia is a hypertensive disorder of pregnancy characterized by maternal endothelial dysfunction and end-organ damage. The antiangiogenic factor, sFlt-1…”
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Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth by Arman, Bridget M, Binder, Natalie K, de Alwis, Natasha, Kaitu’u-Lino, Tu’uhevaha J, Hannan, Natalie J

“…In brief Preterm birth is the leading cause of perinatal morbidity and mortality; however, current therapies offer limited efficacy to delay birth and improve…”
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Investigating the Effects of Atrial Natriuretic Peptide on the Maternal Endothelium to Determine Potential Implications for Preeclampsia by Binder, Natalie K, Beard, Sally, de Alwis, Natasha, Fato, Bianca R, Nguyen, Tuong-Vi, Kaitu'u-Lino, Tu'uhevaha J, Hannan, Natalie J

“…Preeclampsia is associated with an increased lifelong risk of cardiovascular disease (CVD). It is not clear whether this is induced by persistent systemic…”
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Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction by Kaitu’u-Lino, Tu’uhevaha J., MacDonald, Teresa M., Cannon, Ping, Nguyen, Tuong-Vi, Hiscock, Richard J., Haan, Nick, Myers, Jenny E., Hastie, Roxanne, Dane, Kirsten M., Middleton, Anna L., Bittar, Intissar, Sferruzzi-Perri, Amanda N., Pritchard, Natasha, Harper, Alesia, Hannan, Natalie J., Kyritsis, Valerie, Crinis, Nick, Hui, Lisa, Walker, Susan P., Tong, Stephen

“…Placental insufficiency can cause fetal growth restriction and stillbirth. There are no reliable screening tests for placental insufficiency, especially…”
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Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction – implications as a preeclampsia treatment by Hannan, Natalie J., Brownfoot, Fiona C., Cannon, Ping, Deo, Minh, Beard, Sally, Nguyen, Tuong V., Palmer, Kirsten R., Tong, Stephen, Kaitu’u-Lino, Tu’uhevaha J.

“…Preeclampsia is a disease of pregnancy associated with placental oxidative stress, inflammation and elevated release of anti-angiogenic factors sFlt-1 and…”
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Investigating ticagrelor in a preclinical pipeline as a novel therapeutic to prevent preterm birth by Arman, Bridget M, Binder, Natalie K, de Alwis, Natasha, Beard, Sally, Garg, Anjali, Kaitu'u-Lino, Tu'uhevaha J, Hannan, Natalie J

“…Preterm birth is the leading cause of perinatal morbidity and mortality, and new therapies that delay preterm birth and improve neonatal outcomes are urgently…”
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Controlling eutrophication by means of water recirculation: An optimal control perspective by Fernández, Francisco J., Martínez, Aurea, Alvarez-Vázquez, Lino J.

“…In this work, the artificial recirculation of water is presented and analyzed, from the perspective of the optimal control of partial differential equations,…”
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Clinical tools and biomarkers to predict preeclampsia by MacDonald, Teresa M, Walker, Susan P, Hannan, Natalie J, Tong, Stephen, Kaitu'u-Lino, Tu'uhevaha J

“…Preeclampsia is pregnancy-specific, and significantly contributes to maternal, and perinatal morbidity and mortality worldwide. An effective predictive test…”
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Plasma metabolites are altered before and after diagnosis of preeclampsia or fetal growth restriction by Bartho, Lucy A., McKeating, Daniel R., Walker, Susan P., Nijagal, Brunda, MacDonald, Teresa M., Pritchard, Natasha, Hannan, Natalie J., Perkins, Anthony V., Tong, Stephen, Kaitu’u-Lino, Tu’uhevaha J.

“…Metabolomics is the study of small molecules (metabolites), within cells, tissues and biofluids. Maternal metabolites can provide important insight into the…”
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Assessment of the Proton Pump Inhibitor, Esomeprazole Magnesium Hydrate and Trihydrate, on Pathophysiological Markers of Preeclampsia in Preclinical Human Models of Disease by de Alwis, Natasha, Fato, Bianca R., Beard, Sally, Binder, Natalie K., Kaitu’u-Lino, Tu’uhevaha J., Onda, Kenji, Hannan, Natalie J.

“…Previously, we demonstrated that the proton pump inhibitor, esomeprazole magnesium hydrate (MH), could have potential as a repurposed treatment against…”
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Assessment of the tocolytic nifedipine in preclinical primary models of preterm birth by Arman, Bridget M., Binder, Natalie K., de Alwis, Natasha, Beard, Sally, Debruin, Danielle A., Hayes, Alan, Tong, Stephen, Kaitu’u-Lino, Tu’uhevaha J., Hannan, Natalie J.

“…Spontaneous preterm birth is the leading cause of perinatal morbidity and mortality. Tocolytics are drugs used in cases of imminent preterm birth to inhibit…”
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Serum Collected from Preeclamptic Pregnancies Drives Vasoconstriction of Human Omental Arteries-A Novel Ex Vivo Model of Preeclampsia for Therapeutic Development by Fato, Bianca R, de Alwis, Natasha, Beard, Sally, Binder, Natalie K, Pritchard, Natasha, Tong, Stephen, Kaitu'u-Lino, Tu'uhevaha J, Hannan, Natalie J

“…New-onset maternal hypertension is a hallmark of preeclampsia, driven by widespread endothelial dysfunction and systemic vasoconstriction. Here, we set out to…”
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Circulating Chemerin Is Elevated in Women With Preeclampsia by Bartho, Lucy A, Kandel, Manju, Walker, Susan P, Cluver, Catherine A, Hastie, Roxanne, Bergman, Lina, Pritchard, Natasha, Cannon, Ping, Nguyen, Tuong-Vi, Wong, Georgia P, MacDonald, Teresa M, Keenan, Emerson, Hannan, Natalie J, Tong, Stephen, Kaitu’u-Lino, Tu’uhevaha J

“…Abstract Background: Preeclampsia is a severe complication of pregnancy. Chemerin is an adipokine secreted from adipose tissue and highly expressed in…”
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