Central effects of isolated fractions from the root of Petiveria alliacea L. (tipi) in mice

Central effects of isolated fractions from the root of Petiveria alliacea L. (tipi) in mice

Petiveria alliacea L. (tipi) a shrub from Phytolaccaceae family is popularly used in folk medicine for treating a wide variety of disorders in South and Central America. To investigate the neuropharmacological properties on experimental animals. The acetate (FA), hexanic (FH), hydroalcoholic (FHA) a...

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Bibliographic Details
Published in:Journal of ethnopharmacology Vol. 120; no. 2; pp. 209 - 214
Main Authors: Gomes, Patrícia B., Noronha, Emmanuelle C., de Melo, Carla Thiciane V., Bezerra, José N.S., Neto, Manoel A., Lino, Cleide S., Vasconcelos, Silvânia M.M., Viana, Glauce S.B., de Sousa, Francisca Cléa F.
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 20-11-2008
Amsterdam; New York: Elsevier
Elsevier
Subjects:
Administration, Oral
Animals
anticonvulsants
Anticonvulsants - administration & dosage
Anticonvulsants - isolation & purification
Anticonvulsants - pharmacology
Behavior, Animal - drug effects
Biological and medical sciences
Central America
central nervous system
Central Nervous System Depressants - administration & dosage
Central Nervous System Depressants - isolation & purification
Central Nervous System Depressants - pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Female
General pharmacology
Injections, Intraperitoneal
laboratory animals
locomotion
Medical sciences
medicinal plants
medicinal properties
Medicine, Traditional
Mice
Motor Activity - drug effects
Petiveria alliacea
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytolaccaceae
Phytolaccaceae - chemistry
plant extracts
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Roots
roots
sedatives
South America
Tipi
traditional medicine
South America
Central America
Petiveria alliacea
Tipi
Phytolaccaceae
Root
Pharmacognosy
Rodentia
Medicinal plant
Vertebrata
Mammalia
Mouse
Dicotyledones
Animal
Angiospermae
Plant origin
Spermatophyta
Below ground plant part
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Summary:Petiveria alliacea L. (tipi) a shrub from Phytolaccaceae family is popularly used in folk medicine for treating a wide variety of disorders in South and Central America. To investigate the neuropharmacological properties on experimental animals. The acetate (FA), hexanic (FH), hydroalcoholic (FHA) and precipitated hydroalcoholic (FHAppt) fractions from the root of tipi were studied to investigate its pharmacological properties in the classical behavioral models (open-field, elevated plus maze-EPM, rotarod, barbiturate-induced sleeping time, forced swimming and pentylenetetrazole (PTZ)-induced convulsions tests) using mice. These fractions were administered intraperitoneally and orally to female mice at single doses of 100 and 200 mg/kg. All these fractions decreased the locomotor activity, rearing and grooming in the open-field test, suggesting a possible central depressant action. No significant effect was evident on motor coordination of the animals in the rotarod test. On EPM, all the fractions of tipi presented a significant reduction on the time of permanence in the open arms, indicating an absence of anxiolytic-like effect. In addition, the fractions increased the immobility time in the forced swimming test and potentiated pentobarbital-induced sleeping time in mice, confirmed a probable sedative and central depressant effect. Furthermore, the fractions increased the latency to the first convulsion and the lethal time of the PTZ-induced convulsions test in the animals, confirmed its popular use as anticonvulsant. Our results suggest that the fractions of P. alliacea L. contains biologically active substance(s) that might be acting in the CNS and have significant depressant and anticonvulsant potentials, supporting folk medicine use of this plant.
Bibliography:http://dx.doi.org/10.1016/j.jep.2008.08.012
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2008.08.012