Search Results - "Linnoila, M."

Early experience and serotonin transporter gene variation interact to influence primate CNS function by BENNETT, A. J, LESCH, K. P, HEILS, A, LONG, J. C, LORENZ, J. G, SHOAF, S. E, CHAMPOUX, M, SUOMI, S. J, LINNOILA, M. V, HIGLEY, J. D

“…Nonhuman primates offer unique opportunities to study the effects of genes, environments, and their interaction, on physiology and complex behavior. We…”
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Early experience and serotonin transporter gene variation interact to influence primate CNS function by Bennett, A J, Lesch, K P, Heils, A, Long, J C, Lorenz, J G, Shoaf, S E, Champoux, M, Suomi, S J, Linnoila, M V, Higley, J D

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Low central nervous system serotonergic activity is traitlike and correlates with impulsive behavior. A nonhuman primate model investigating genetic and environmental influences on neurotransmission by Higley, J D, Linnoila, M

“…We have used nonhuman primates to examine developmental and behavioral correlates of CNS serotonergic activity, as measured by concentrations of the serotonin…”
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Modification of human 5-HT2C receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution by OKADA, M, NORTHUP, J. K, OZAKI, N, RUSSELL, J. T, LINNOILA, M, GOLDMAN, D

“…A human serotonin (5-HT)(2C) receptor gene polymorphism leads to the substitution of cysteine for serine at codon 23 (Cys23Ser); the frequency of the Ser23…”
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Effects of Acute Tryptophan Depletion on Plasma and Cerebrospinal Fluid Tryptophan and 5‐Hydroxyindoleacetic Acid in Normal Volunteers by Williams, W. A., Shoaf, S. E., Hommer, D., Rawlings, R., Linnoila, M.

“…: Brain serotonin synthesis and metabolism (turnover), as indicated by CSF concentrations of 5‐hydroxyindoleacetic acid (5‐HIAA), may depend on plasma…”
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Mu opioid receptor gene variants: lack of association with alcohol dependence by Bergen, A W, Kokoszka, J, Peterson, R, Long, J C, Virkkunen, M, Linnoila, M, Goldman, D

“…The mu opioid receptor is implicated in the reward, tolerance and withdrawal effects of alcohol and other drugs of abuse. This hypothesis is supported by the…”
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The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking by Malhotra, A K, Virkkunen, M, Rooney, W, Eggert, M, Linnoila, M, Goldman, D

“…Ebstein and colleagues have recently reported a significant association between the 7-repeat allele of the dopamine D4 receptor (D4DR) 16 amino acid repeat…”
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A nonhuman primate model of type II excessive alcohol consumption? Part 1. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations and diminished social competence correlate with excessive alcohol consumption by Higley, J D, Suomi, S J, Linnoila, M

“…Developmental, biochemical, and behavioral concomitants of excessive alcohol consumption were investigated using a nonhuman primate model. The variables of…”
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Effects of isolation-rearing on voluntary consumption of ethanol, sucrose and saccharin solutions in Fawn Hooded and Wistar rats by HALL, F. S, HUANG, S, FONG, G. W, PERT, A, LINNOILA, M

“…These experiments examined the hypothesis that isolation-rearing and strain influence hedonic mechanisms. In experiment 1, voluntary consumption of ethanol and…”
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Effects of isolation-rearing on locomotion, anxiety and responses to ethanol in Fawn Hooded and Wistar rats by HALL, F. S, HUANG, S, FONG, G. W, PERT, A, LINNOILA, M

“…Voluntary ethanol (EtOH) consumption is increased by isolation-rearing in several rat strains. The following experiments examined the effects of…”
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Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates by Mehlman, P T, Higley, J D, Faucher, I, Lilly, A A, Taub, D M, Vickers, J, Suomi, S J, Linnoila, M

“…The purpose of this study was to examine the relationship between behavior and serotonin by using a nonhuman primate model of aggression and impulse control…”
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Nonhuman Primate Model of Alcohol Abuse: Effects of Early Experience, Personality, and Stress on Alcohol Consumption by Higley, J. D., Hasert, M. F., Suomi, S. J., Linnoila, M.

“…Twenty-two 50-month-old rhesus monkeys were provided concurrent free access to an aspartame-sweetened 7% ethanol solution and an aspartame-sweetened vehicle…”
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A nonhuman primate model of type II alcoholism? Part 2. Diminished social competence and excessive aggression correlates with low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations by Higley, J D, Suomi, S J, Linnoila, M

“…The purpose of this study was to develop an animal model for behavioral features of type II, early-onset alcohol abuse. To perform this research, cerebrospinal…”
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Stability of interindividual differences in serotonin function and its relationship to severe aggression and competent social behavior in Rhesus Macaque females by Higley, J.D., King, S.T., Hasert, M.F., Champoux, M., Suomi, S.J., Linnoila, M.

“…Few studies have investigated longitudinally interindividual stability of cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) concentrations in adult…”
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Identification of four variants in the tryptophan hydroxylase promoter and association to behavior by ROTONDO, A, SCHUEBEL, K. E, BERGEN, A. W, ARAGON, R, VIRKKUNEN, M, LINNOILA, M, GOLDMAN, D, NIELSEN, D. A

“…One of the most replicated findings in biological psychiatry is the observation of lower 5-hydroxyindoleacetic acid concentrations, the major metabolite of…”
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Low brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence by VIRKKUNEN, M, GOLDMAN, D, NIELSEN, D. A, LINNOILA, M

“…The findings of a series of studies by the authors support the idea that most impulsive offenders who have a tendency to behave aggressively while intoxicated…”
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Criminal and psychiatric histories of Finnish arsonists by Repo, E., Virkkunen, M., Rawlings, R., Linnoila, M.

“…We investigated psychiatric and demographic variables and lifetime criminality among arsonists referred for a pre‐trial psychiatric assessment. The medical and…”
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CSF serotonin metabolite (5-HIAA) studies in depression, impulsivity, and violence by Brown, G L, Linnoila, M I

“…A neuroanatomical central nervous system (CNS) mechanism for the expression of emotions and behaviors in animals has now been proposed for over 50 years. More…”
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The Serotonin Reuptake Inhibitor Sertraline Reduces Excessive Alcohol Consumption in Nonhuman Primates: Effect of Stress by Higley, Ph.D, J, Hasert, M.S, M, Suomi, Ph.D, S, Linnoila, M.D., Ph.D, M

“…Many monkeys that are reared without adult influence, with only peers, voluntarily consume alcohol in amounts producing intoxication on a relatively regular…”
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Correlation of CSF 5-HIAA concentration with sociality and the timing of emigration in free-ranging primates by Mehlman, P T, Higley, J D, Faucher, I, Lilly, A A, Taub, D M, Vickers, J, Suomi, S J, Linnoila, M

“…The purpose of this study was to examine the relationship between behavior and serotonin in nonhuman primates. During a routine capture and medical…”
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