Search Results - "Linn, Michael"

MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models by TOVAR, Christian, GRAVES, Bradford, LINN, Michael, PODLASKI, Frank, WOVKULICH, Peter, VU, Binh, VASSILEV, Lyubomir T, PACKMAN, Kathryn, FILIPOVIC, Zoran, HIGGINS MINGXUAN XIA, Brian, TARDELL, Christine, GARRIDO, Rosario, LEE, Edmund, KOLINSKY, Kenneth, TO, Kwong-Him

“…MDM2 negatively regulates p53 stability and many human tumors overproduce MDM2 as a mechanism to restrict p53 function. Thus, inhibitors of p53-MDM2 binding…”
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Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo by Linn, Michael, Collnot, Eva-Maria, Djuric, Dejan, Hempel, Katja, Fabian, Eric, Kolter, Karl, Lehr, Claus-Michael

“…As many new active pharmaceutical ingredients are poorly water soluble, solubility enhancers are one possibility to overcome the hurdles of drug dissolution…”
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A Very Active Cu-Catalytic System for the Synthesis of Aryl, Heteroaryl, and Vinyl Sulfides by Kabir, M. Shahjahan, Lorenz, Michael, Van Linn, Michael L, Namjoshi, Ojas A, Ara, Shamim, Cook, James M

“…cis-1,2-Cyclohexanediol (L3) has been shown to be an efficient and versatile bidentate O-donor ligand that provides a highly active Cu-catalytic system. It was…”
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Operative Versus Conservative Management of Displaced Tibial Shaft Fracture in Adolescents by Kinney, Matthew C, Nagle, David, Bastrom, Tracey, Linn, Michael S, Schwartz, Alexandra K, Pennock, Andrew T

“…BACKGROUND:Displaced tibial shaft fractures are common in adolescent patients, yet there is no standardized management strategy. We compared surgical fixation…”
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Mechanistic Studies on the Cis to Trans Epimerization of Trisubstituted 1,2,3,4-Tetrahydro-β-carbolines by Van Linn, Michael L, Cook, James M

“…It is well-known that N b-benzyltryptophan alkyl esters undergo the Pictet−Spengler reaction with aldehydes to furnish both cis- and…”
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Dynamic Locked Plating of Distal Femur Fractures by Linn, Michael S, McAndrew, Christopher M, Prusaczyk, Beth, Brimmo, Olubusola, Ricci, William M, Gardner, Michael J

“…OBJECTIVES:Nonunion after locked bridge plating of comminuted distal femur fractures is not uncommon. “Dynamic” locked plating may create an improved…”
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Incidental Ultrastructural Findings in the Sural Nerve and Dorsal Root Ganglion of Aged Control Sprague Dawley Rats in a Nonclinical Carcinogenicity Study by Meier, William A., Linn, Michael J., Davis, Wendell P., Sutherland, Jessica E., Sharma, Alok K.

“…Xenobiotic-induced peripheral nerve damage is a growing concern. Identifying relative risks that a new drug may cause peripheral nerve injury over long periods…”
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Simulating clamp placement across the trans-syndesmotic angle of the ankle to minimize malreduction: A radiological study by Putnam, Sara M, Linn, Michael S, Spraggs-Hughes, Amanda, McAndrew, Christopher M, Ricci, William M, Gardner, Michael J

“…Abstract Background Ankle fractures associated with syndesmotic injury have a poorer prognosis than those without such an injury. Anatomic reduction of the…”
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Is primary total elbow arthroplasty safe for the treatment of open intra-articular distal humerus fractures? by Linn, Michael S, Gardner, Michael J, McAndrew, Christopher M, Gallagher, Bethany, Ricci, William M

“…Abstract Objectives Total elbow arthroplasty (TEA) is a viable treatment for elderly patients with distal humerus fracture who frequently present with…”
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Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress by Vinkers, Christiaan H., Klanker, Marianne, Groenink, Lucianne, Korte, S. Mechiel, Cook, James M., Van Linn, Michael L., Hopkins, Seth C., Olivier, Berend

“…Rationale The stress-induced hyperthermia (SIH) model is an anxiety model that uses the transient rise in body temperature in response to acute stress…”
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Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation by Fischer, Bradford D., Teixeira, Laura P., van Linn, Michael L., Namjoshi, Ojas A., Cook, James M., Rowlett, James K.

“…Rationale Assays of schedule-controlled responding can be used to characterize the pharmacology of benzodiazepines and other GABA A receptor modulators, and…”
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Stereo- and Regiospecific Cu-Catalyzed Cross-Coupling Reaction of Vinyl Iodides and Thiols: A Very Mild and General Route for the Synthesis of Vinyl Sulfides by Kabir, M. Shahjahan, Van Linn, Michael L, Monte, Aaron, Cook, James M

“…A mild and efficient method for the copper-catalyzed formation of vinylic carbon−sulfur bonds has been developed. The desired vinyl sulfides are obtained in…”
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Etanercept Enhances Preservation of Osteochondral Allograft Viability by Linn, Michael S., Chase, Derek C., Healey, Robert M., Harwood, Frederick L., Bugbee, William D., Amiel, David

“…Background: Osteochondral allografts are an increasingly popular treatment for the repair of articular cartilage lesions. Current tissue bank protocols require…”
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Effects of the benzodiazepine GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on alcohol seeking and self-administration in baboons by Kaminski, Barbara J., Van Linn, Michael L., Cook, James M., Yin, Wenyuan, Weerts, Elise M.

“…Rationale The various α subtypes of GABA A receptors have been strongly implicated in alcohol reinforcement and consumption. Objectives The effects of the GABA…”
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The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats by Milić, Marija, Divljaković, Jovana, Rallapalli, Sundari, van Linn, Michael L, Timić, Tamara, Cook, James M, Savić, Miroslav M

“…Benzodiazepines negatively affect motor coordination and balance and produce myorelaxation. The aim of the present study was to examine the extent to which…”
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Popliteal artery pseudoaneurysm: an unusual complication of tibial traction by Linn, Michael S, Indresano, Andrew A, Schwartz, Alexandra

“…Traction pins are an essential tool in the orthopedic surgeon's armamentarium. Historically a definitive treatment for some fractures, they are mainly used as…”
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Development of a Two-Step Route to 3-PBC and βCCt, Two Agents Active against Alcohol Self-Administration in Rodent and Primate Models by Namjoshi, Ojas A, Gryboski, Angelica, Fonseca, German O, Van Linn, Michael L, Wang, Zhi-jian, Deschamps, Jeffrey R, Cook, James M

“…To gain access to 3-propoxy-β-carboline hydrochloride (3-PBC·HCl) (1·HCl) and β-carboline-3-carboxylate-tert-butyl ester (βCCt) (2), potential clinical agents…”
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What Happens to Serum Metal Ion Levels After a Metal-on-Metal Bearing is Removed? by Ball, Scott T., MD, Severns, Dustyn, PA-C, Linn, Michael, MD, Meyer, R. Scott, MD, Swenson, F. Craig, MD

“…Abstract Serum cobalt (Co) and chromium (Cr) levels are commonly used to screen for excessive wear of metal-on-metal hip replacements. However, it is unknown…”
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Augmentation of Tendon Healing With Butyric Acid–Impregnated Sutures: Biomechanical Evaluation in a Rabbit Model by Leek, Bryan T., Tasto, James P., Tibor, Lisa M., Healey, Robert M., Freemont, Anthony, Linn, Michael S., Chase, Derek E., Amiel, David

“…Background: Butyric acid (BA) has been shown to be angiogenic and to enhance transcriptional activity in tissue. These properties of BA have the potential to…”
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Little Evidence of a Role for the α1GABAA Subunit-Containing Receptor in a Rhesus Monkey Model of Alcohol Drinking by Sawyer, Eileen K., Moran, Casey, Sirbu, Madelynn H., Szafir, Melissa, Van Linn, Michael, Namjoshi, Ojas, Phani Babu Tiruveedhula, VVN, Cook, James M., Platt, Donna M.

“…Background Alcohol potentiates GABAergic neurotransmission via action at the GABAA receptor. α1 subunit‐containing GABAA receptors have been implicated as…”
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