Search Results - "Linley, E"

Neurological perspectives on voltage-gated sodium channels by EIJKELKAMP, Niels, LINLEY, John E, BAKER, Mark D, MINETT, Michael S, CREGG, Roman, WERDEHAUSEN, Robert, RUGIERO, François, WOOD, John N

“…The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic…”
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The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels by Liu, Boyi, Linley, John E, Du, Xiaona, Zhang, Xuan, Ooi, Lezanne, Zhang, Hailin, Gamper, Nikita

“…Bradykinin (BK) is an inflammatory mediator and one of the most potent endogenous pain-inducing substances. When released at sites of tissue damage or…”
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Following the Omicron wave, the majority of children in England have evidence of previous COVID infection by Oeser, C, Whitaker, H, Borrow, R, Linley, E, Tonge, S, Rowe, C, Otter, A, Warrener, L, Campbell, CNJ, Ladhani, S, Ramsay, M, Brown, KE, Amirthalingam, G

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Mode of action of hydrogen peroxide and other oxidizing agents: differences between liquid and gas forms by Finnegan, Michelle, Linley, Ezra, Denyer, Stephen P., McDonnell, Gerald, Simons, Claire, Maillard, Jean-Yves

“…Objectives Antimicrobials such as chlorine dioxide, peracetic acid and hydrogen peroxide (H2O2) share a basic mechanism of action (chemical oxidation of…”
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Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons by Linley, John E., Ooi, Lezanne, Pettinger, Louisa, Kirton, Hannah, Boyle, John P., Peers, Chris, Gamper, Nikita

“…Substance P (SP) is a prominent neuromodulator, which is produced and released by peripheral damage-sensing (nociceptive) neurons; these neurons also express…”
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Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain by Williams, Wendy A., Linley, John E., Jones, Clare A., Shibata, Yoko, Snijder, Arjan, Button, James, Hatcher, Jon P., Huang, Ling, Taddese, Bruck, Thornton, Peter, Schofield, Darren J., Thom, George, Popovic, Bojana, Dosanjh, Bhupinder, Wilkinson, Trevor, Hughes, Jane, Dobson, Claire L., Groves, Maria A., Webster, Carl I., Billinton, Andy, Vaughan, Tristan J., Chessell, Iain

“…P2X4 is a ligand-gated ion channel implicated in neuropathic pain. Drug discovery efforts targeting P2X4 have been unsuccessful largely because of the…”
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Understanding inflammatory pain: ion channels contributing to acute and chronic nociception by Linley, John E., Rose, Kirstin, Ooi, Lezanne, Gamper, Nikita

“…Inflammatory pain results from the increased excitability of peripheral nociceptive sensory fibres produced by the action of inflammatory mediators. This…”
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The role of the exosporium in the environmental distribution of anthrax by Williams, G., Linley, E., Nicholas, R., Baillie, L.

“…Aims To determine the contribution of the exosporium, the outer layer of the Bacillus anthracis spore, to soil attachment. Persistence of spores in soil and…”
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Inhibition of M Current in Sensory Neurons by Exogenous Proteases: A Signaling Pathway Mediating Inflammatory Nociception by Linley, John E, Rose, Kirstin, Patil, Mayur, Robertson, Brian, Akopian, Armen N, Gamper, Nikita

“…Inflammatory pain is thought to be mediated in part through the action of inflammatory mediators on membrane receptors of peripheral nerve terminals, however,…”
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Recombinant expression and in vitro characterisation of active Huwentoxin-IV by Sermadiras, Isabelle, Revell, Jefferson, Linley, John E, Sandercock, Alan, Ravn, Peter

“…Huwentoxin-IV (HwTx-IV) is a 35-residue neurotoxin peptide with potential application as a novel analgesic. It is a member of the inhibitory cystine knot (ICK)…”
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TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells by Quick, Kathryn, Zhao, Jing, Eijkelkamp, Niels, Linley, John E., Rugiero, Francois, Cox, James J., Raouf, Ramin, Gringhuis, Martine, Sexton, Jane E., Abramowitz, Joel, Taylor, Ruth, Forge, Andy, Ashmore, Jonathan, Kirkwood, Nerissa, Kros, Corné J., Richardson, Guy P., Freichel, Marc, Flockerzi, Veit, Birnbaumer, Lutz, Wood, John N.

“…Transient receptor potential (TRP) channels TRPC3 and TRPC6 are expressed in both sensory neurons and cochlear hair cells. Deletion of TRPC3 or TRPC6 in mice…”
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Calcium imaging for analgesic drug discovery by Iseppon, Federico, Linley, John E., Wood, John N.

“…•Calcium imaging is an efficient way to dissect the activity of neurons in vivo.•GCaMP indicators can be expressed in specific cell populations for in vivo…”
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Community seroprevalence of SARS-CoV-2 in children and adolescents in England, 2019–2021 by Ratcliffe, Helen, Tiley, K S, Andrews, Nick, Amirthalingam, Gayatri, Vichos, I, Morey, E, Douglas, N L, Marinou, S, Plested, Emma, Aley, Parvinder, Galiza, Eva P, Faust, Saul N, Hughes, S, Murray, Clare S, Roderick, Marion, Shackley, Fiona, Oddie, Sam J, Lees, Tim, Turner, D P J, Raman, M, Owens, Stephen, Turner, Paul, Cockerill, H, Lopez Bernal, J, Linley, E, Borrow, Ray, Brown, Kevin, Ramsay, Mary Elizabeth, Voysey, M, Snape, Matthew D

“…ObjectiveTo understand community seroprevalence of SARS-CoV-2 in children and adolescents. This is vital to understanding the susceptibility of this cohort to…”
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Use of hydrogen peroxide as a biocide: new consideration of its mechanisms of biocidal action by LINLEY, Ezra, DENYER, Stephen P, MCDONNELL, Gerald, SIMONS, Claire, MAILLARD, Jean-Yves

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Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication by Salinas, Eduardo, Byrum, Stephanie D, Moreland, Linley E, Mackintosh, Samuel G, Tackett, Alan J, Forrest, J Craig

“…Latency-associated nuclear antigen (LANA) is a conserved, multifunctional protein encoded by members of the rhadinovirus subfamily of gammaherpesviruses,…”
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Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia by Koenig, Jennifer, Werdehausen, Robert, Linley, John E, Habib, Abdella M, Vernon, Jeffrey, Lolignier, Stephane, Eijkelkamp, Niels, Zhao, Jing, Okorokov, Andrei L, Woods, C Geoffrey, Wood, John N, Cox, James J

“…The Nav1.7 voltage-gated sodium channel, encoded by SCN9A, is critical for human pain perception yet the transcriptional and post-transcriptional mechanisms…”
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Regulation of Locomotor activity in fed, fasted, and food-restricted mice lacking tissue-type plasminogen activator by Krizo, Jessica A, Moreland, Linley E, Rastogi, Ashutosh, Mou, Xiang, Prosser, Rebecca A, Mintz, Eric M

“…Circadian rhythms of physiology and behavior are driven by a circadian clock located in the suprachiasmatic nucleus of the hypothalamus. This clock is…”
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M channel enhancers and physiological M channel block by Linley, John E., Pettinger, Louisa, Huang, Dongyang, Gamper, Nikita

“…Non‐technical summary  Specific membrane proteins called ‘M channels’ control the excitability of peripheral pain‐sensing nerves. In certain disease conditions…”
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Integrins and proximal signaling mechanisms in cardiovascular disease by Lal, Hind, Verma, Suresh K, Foster, Donald M, Golden, Honey B, Reneau, John C, Watson, Linley E, Singh, Hitesh, Dostal, David E

“…Integrins are heterodimeric cell-surface molecules, which act as the principle mediators of molecular dialog between a cell and its extracellular matrix…”
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Anthrax toxins induce shock in rats by depressed cardiac ventricular function by Watson, Linley E, Kuo, Shu-Ru, Katki, Khurshed, Dang, Tongyun, Park, Seong Kyu, Dostal, David E, Tang, Wei-Jen, Leppla, Stephen H, Frankel, Arthur E

“…Anthrax infections are frequently associated with severe and often irreversible hypotensive shock. The isolated toxic proteins of Bacillus anthracis produce a…”
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