Search Results - "Linke, Wolfgang A."

Titin Gene and Protein Functions in Passive and Active Muscle by Linke, Wolfgang A

“…The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein titin, which is a scaffolding filament, signaling platform, and…”
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Stretching the story of titin and muscle function by Linke, Wolfgang A.

“…The discovery of the giant protein titin, also known as connectin, dates almost half a century back. In this review, I recapitulate major advances in the…”
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Titin as a force-generating muscle protein under regulatory control by Freundt, Johanna K, Linke, Wolfgang A

“…Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres…”
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Titin (TTN): from molecule to modifications, mechanics, and medical significance by Loescher, Christine M, Hobbach, Anastasia J, Linke, Wolfgang A

“…The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and contributor to cardiac strain sensing. Titin-based forces are highly…”
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Work Done by Titin Protein Folding Assists Muscle Contraction by Rivas-Pardo, Jaime Andrés, Eckels, Edward C., Popa, Ionel, Kosuri, Pallav, Linke, Wolfgang A., Fernández, Julio M.

“…Current theories of muscle contraction propose that the power stroke of a myosin motor is the sole source of mechanical energy driving the sliding filaments of…”
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Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy by Hinson, John T., Chopra, Anant, Nafissi, Navid, Polacheck, William J., Benson, Craig C., Swist, Sandra, Gorham, Joshua, Yang, Luhan, Schafer, Sebastian, Sheng, Calvin C., Haghighi, Alireza, Homsy, Jason, Hubner, Norbert, Church, George, Cook, Stuart A., Linke, Wolfgang A., Chen, Christopher S., Seidman, J. G., Seidman, Christine E.

“…Human mutations that truncate the massive sarcomere protein titin [TTN-truncating variants (TTNtvs)] are the most common genetic cause for dilated…”
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Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function by Zacchigna, Serena, Paldino, Alessia, Falcão-Pires, Inês, Daskalopoulos, Evangelos P, Dal Ferro, Matteo, Vodret, Simone, Lesizza, Pierluigi, Cannatà, Antonio, Miranda-Silva, Daniela, Lourenço, André P, Pinamonti, Bruno, Sinagra, Gianfranco, Weinberger, Florian, Eschenhagen, Thomas, Carrier, Lucie, Kehat, Izhak, Tocchetti, Carlo G, Russo, Michele, Ghigo, Alessandra, Cimino, James, Hirsch, Emilio, Dawson, Dana, Ciccarelli, Michele, Oliveti, Marco, Linke, Wolfgang A, Cuijpers, Ilona, Heymans, Stephane, Hamdani, Nazha, de Boer, Martine, Duncker, Dirk J, Kuster, Diederik, van der Velden, Jolanda, Beauloye, Christophe, Bertrand, Luc, Mayr, Manuel, Giacca, Mauro, Leuschner, Florian, Backs, Johannes, Thum, Thomas

“…Abstract Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant…”
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S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding by Alegre-Cebollada, Jorge, Kosuri, Pallav, Giganti, David, Eckels, Edward, Rivas-Pardo, Jaime Andrés, Hamdani, Nazha, Warren, Chad M., Solaro, R. John, Linke, Wolfgang A., Fernández, Julio M.

“…The giant elastic protein titin is a determinant factor in how much blood fills the left ventricle during diastole and thus in the etiology of heart disease…”
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Titin force in muscle cells alters lattice order, thick and thin filament protein formation by Hessel, Anthony L, Ma, Weikang, Mazara, Nicole, Rice, Paige E, Nissen, Devin, Gong, Henry, Kuehn, Michel, Irving, Thomas, Linke, Wolfgang A

“…Skeletal muscle force production is increased at longer compared to shorter muscle lengths because of length-dependent priming of thick filament proteins in…”
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Emerging importance of oxidative stress in regulating striated muscle elasticity by Beckendorf, Lisa, Linke, Wolfgang A.

“…The contractile function of striated muscle cells is altered by oxidative/nitrosative stress, which can be observed under physiological conditions but also in…”
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Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction by Franssen, Constantijn, MD, Chen, Sophia, BSc, Unger, Andreas, PhD, Korkmaz, H. Ibrahim, MSc, De Keulenaer, Gilles W., MD, PhD, Tschöpe, Carsten, MD, PhD, Leite-Moreira, Adelino F., MD, PhD, Musters, René, PhD, Niessen, Hans W.M., MD, PhD, Linke, Wolfgang A., PhD, Paulus, Walter J., MD, PhD, Hamdani, Nazha, PhD

“…Abstract Objectives The present study investigated whether systemic, low-grade inflammation of metabolic risk contributed to diastolic left ventricular (LV)…”
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Titin stiffness modifies the force-generating region of muscle sarcomeres by Li, Yong, Lang, Patrick, Linke, Wolfgang A.

“…The contractile units of striated muscle, the sarcomeres, comprise the thick (myosin) and thin (actin) filaments mediating active contraction and the titin…”
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The giant protein titin as an integrator of myocyte signaling pathways by Linke, Wolfgang A, Krüger, Martina

“…The giant muscle protein titin, the "backbone" of the sarcomere, harbors a complex molecular spring whose stiffness is variably tuned in health and disease…”
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Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart by Tocchetti, Carlo Gabriele, Ameri, Pietro, de Boer, Rudolf A, D’Alessandra, Yuri, Russo, Michele, Sorriento, Daniela, Ciccarelli, Michele, Kiss, Bernadett, Bertrand, Luc, Dawson, Dana, Falcao-Pires, Ines, Giacca, Mauro, Hamdani, Nazha, Linke, Wolfgang A, Mayr, Manuel, van der Velden, Jolanda, Zacchigna, Serena, Ghigo, Alessandra, Hirsch, Emilio, Lyon, Alexander R, Görbe, Anikó, Ferdinandy, Péter, Madonna, Rosalinda, Heymans, Stephane, Thum, Thomas

“…Abstract In western countries, cardiovascular (CV) disease and cancer are the leading causes of death in the ageing population. Recent epidemiological data…”
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Crucial Role for Ca2+/Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation by Hamdani, Nazha, Krysiak, Judith, Kreusser, Michael M, Neef, Stefan, dos Remedios, Cristobal G, Maier, Lars S, Krüger, Markus, Backs, Johannes, Linke, Wolfgang A

“…RATIONALE:Myocardial diastolic stiffness and cardiomyocyte passive force (Fpassive) depend in part on titin isoform composition and phosphorylation…”
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Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins by Kötter, Sebastian, Unger, Andreas, Hamdani, Nazha, Lang, Patrick, Vorgerd, Matthias, Nagel-Steger, Luitgard, Linke, Wolfgang A

“…In myocytes, small heat shock proteins (sHSPs) are preferentially translocated under stress to the sarcomeres. The functional implications of this…”
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Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function by Zaunbrecher, Rebecca J, Abel, Ashley N, Beussman, Kevin, Leonard, Andrea, von Frieling-Salewsky, Marion, Fields, Paul A, Pabon, Lil, Reinecke, Hans, Yang, Xiulan, Macadangdang, Jesse, Kim, Deok-Ho, Linke, Wolfgang A, Sniadecki, Nathan J, Regnier, Michael, Murry, Charles E

“…BACKGROUND:The giant sarcomere protein titin is important in both heart health and disease. Mutations in the gene encoding for titin (TTN) are the leading…”
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Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes by Krysiak, Judith, Unger, Andreas, Beckendorf, Lisa, Hamdani, Nazha, von Frieling-Salewsky, Marion, Redfield, Margaret M., dos Remedios, Cris G., Sheikh, Farah, Gergs, Ulrich, Boknik, Peter, Linke, Wolfgang A.

“…Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Under basal…”
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Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin by Swist, Sandra, Unger, Andreas, Li, Yong, Vöge, Anja, von Frieling-Salewsky, Marion, Skärlén, Åsa, Cacciani, Nicola, Braun, Thomas, Larsson, Lars, Linke, Wolfgang A.

“…The giant protein titin is thought to be required for sarcomeric integrity in mature myocytes, but direct evidence for this hypothesis is limited. Here, we…”
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Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads by Hessel, Anthony L., Engels, Nichlas M., Kuehn, Michel N., Nissen, Devin, Sadler, Rachel L., Ma, Weikang, Irving, Thomas C., Linke, Wolfgang A., Harris, Samantha P.

“…Muscle contraction is produced via the interaction of myofilaments and is regulated so that muscle performance matches demand. Myosin-binding protein C…”
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