Search Results - "Link, Verena M."

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities by Gosselin, David, Link, Verena M., Romanoski, Casey E., Fonseca, Gregory J., Eichenfield, Dawn Z., Spann, Nathanael J., Stender, Joshua D., Chun, Hyun B., Garner, Hannah, Geissmann, Frederic, Glass, Christopher K.

“…Macrophages reside in essentially all tissues of the body and play key roles in innate and adaptive immune responses. Distinct populations of tissue…”
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Infection trains the host for microbiota-enhanced resistance to pathogens by Stacy, Apollo, Andrade-Oliveira, Vinicius, McCulloch, John A., Hild, Benedikt, Oh, Ji Hoon, Perez-Chaparro, P. Juliana, Sim, Choon K., Lim, Ai Ing, Link, Verena M., Enamorado, Michel, Trinchieri, Giorgio, Segre, Julia A., Rehermann, Barbara, Belkaid, Yasmine

“…The microbiota shields the host against infections in a process known as colonization resistance. How infections themselves shape this fundamental process…”
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The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction by Collins, Nicholas, Han, Seong-Ji, Enamorado, Michel, Link, Verena M., Huang, Bonnie, Moseman, E. Ashley, Kishton, Rigel J., Shannon, John P., Dixit, Dhaval, Schwab, Susan R., Hickman, Heather D., Restifo, Nicholas P., McGavern, Dorian B., Schwartzberg, Pamela L., Belkaid, Yasmine

“…Mammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we…”
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Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring by Lim, Ai Ing, McFadden, Taryn, Link, Verena M., Han, Seong-Ji, Karlsson, Rose-Marie, Stacy, Apollo, Farley, Taylor K., Lima-Junior, Djalma S., Harrison, Oliver J., Desai, Jigar V., Lionakis, Michail S., Shih, Han-Yu, Cameron, Heather A., Belkaid, Yasmine

“…Mom’s IL-6 rewires baby’s gut immunity Most infections that occur during pregnancy are mild and transient. However, whether such pathogen encounters can shape…”
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Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine by Pirzgalska, Roksana M, Seixas, Elsa, Seidman, Jason S, Link, Verena M, Sánchez, Noelia Martínez, Mahú, Inês, Mendes, Raquel, Gres, Vitka, Kubasova, Nadiya, Morris, Imogen, Arús, Bernardo A, Larabee, Chelsea M, Vasques, Miguel, Tortosa, Francisco, Sousa, Ana L, Anandan, Sathyavathy, Tranfield, Erin, Hahn, Maureen K, Iannacone, Matteo, Spann, Nathanael J, Glass, Christopher K, Domingos, Ana I

“…Sympathetic neuron–associated macrophages act as a local sink for norepinephrine, leading to reduced thermogenesis and increased obesity. The cellular…”
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Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis by Seidman, Jason S., Troutman, Ty D., Sakai, Mashito, Gola, Anita, Spann, Nathanael J., Bennett, Hunter, Bruni, Cassi M., Ouyang, Zhengyu, Li, Rick Z., Sun, Xiaoli, Vu, BaoChau T., Pasillas, Martina P., Ego, Kaori M., Gosselin, David, Link, Verena M., Chong, Ling-Wa, Evans, Ronald M., Thompson, Bonne M., McDonald, Jeffrey G., Hosseini, Mojgan, Witztum, Joseph L., Germain, Ronald N., Glass, Christopher K.

“…Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues,…”
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SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism by Oishi, Yumiko, Spann, Nathanael J., Link, Verena M., Muse, Evan D., Strid, Tobias, Edillor, Chantle, Kolar, Matthew J., Matsuzaka, Takashi, Hayakawa, Sumio, Tao, Jenhan, Kaikkonen, Minna U., Carlin, Aaron F., Lam, Michael T., Manabe, Ichiro, Shimano, Hitoshi, Saghatelian, Alan, Glass, Christopher K.

“…Macrophages play pivotal roles in both the induction and resolution phases of inflammatory processes. Macrophages have been shown to synthesize…”
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Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages by Fonseca, Gregory J., Tao, Jenhan, Westin, Emma M., Duttke, Sascha H., Spann, Nathanael J., Strid, Tobias, Shen, Zeyang, Stender, Joshua D., Sakai, Mashito, Link, Verena M., Benner, Christopher, Glass, Christopher K.

“…Mechanisms by which members of the AP-1 family of transcription factors play non-redundant biological roles despite recognizing the same DNA sequence remain…”
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A Cdk4/6-dependent phosphorylation gradient regulates the early to late G1 phase transition by Kaulich, Manuel, Link, Verena M., Lapek, John D., Lee, Yeon J., Glass, Christopher K., Gonzalez, David J., Dowdy, Steven F.

“…During early G1 phase, Rb is exclusively mono-phosphorylated by cyclin D:Cdk4/6, generating 14 different isoforms with specific binding patterns to E2Fs and…”
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Exploiting genomics and natural genetic variation to decode macrophage enhancers by Romanoski, Casey E, Link, Verena M, Heinz, Sven, Glass, Christopher K

“…Highlights • Enhancers are major determinants of cell specific gene expression. • Small sets of lineage-determining factors prime the majority of macrophage…”
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Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages by Eichenfield, Dawn Z, Troutman, Ty Dale, Link, Verena M, Lam, Michael T, Cho, Han, Gosselin, David, Spann, Nathanael J, Lesch, Hanna P, Tao, Jenhan, Muto, Jun, Gallo, Richard L, Evans, Ronald M, Glass, Christopher K

“…Although macrophages can be polarized to distinct phenotypes in vitro with individual ligands, in vivo they encounter multiple signals that control their…”
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Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities by Gosselin, David, Link, Verena M., Romanoski, Casey E., Fonseca, Gregory J., Eichenfield, Dawn Z., Spann, Nathanael J., Stender, Joshua D., Chun, Hyun B., Garner, Hannah, Geissmann, Frederic, Glass, Christopher K.

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Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity by Sakai, Mashito, Troutman, Ty D., Seidman, Jason S., Ouyang, Zhengyu, Spann, Nathanael J., Abe, Yohei, Ego, Kaori M., Bruni, Cassi M., Deng, Zihou, Schlachetzki, Johannes C.M., Nott, Alexi, Bennett, Hunter, Chang, Jonathan, Vu, BaoChau T., Pasillas, Martina P., Link, Verena M., Texari, Lorane, Heinz, Sven, Thompson, Bonne M., McDonald, Jeffrey G., Geissmann, Frederic, Glass, Christopher K.

“…Tissue environment plays a powerful role in establishing and maintaining the distinct phenotypes of resident macrophages, but the underlying molecular…”
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MAIT cells are imprinted by the microbiota in early life and promote tissue repair by Constantinides, Michael G, Link, Verena M, Tamoutounour, Samira, Wong, Andrea C, Perez-Chaparro, P Juliana, Han, Seong-Ji, Chen, Y Erin, Li, Kelin, Farhat, Sepideh, Weckel, Antonin, Krishnamurthy, Siddharth R, Vujkovic-Cvijin, Ivan, Linehan, Jonathan L, Bouladoux, Nicolas, Merrill, E Dean, Roy, Sobhan, Cua, Daniel J, Adams, Erin J, Bhandoola, Avinash, Scharschmidt, Tiffany C, Aubé, Jeffrey, Fischbach, Michael A, Belkaid, Yasmine

“…How early-life colonization and subsequent exposure to the microbiota affect long-term tissue immunity remains poorly understood. Here, we show that the…”
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Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota by Lima-Junior, Djalma S., Krishnamurthy, Siddharth R., Bouladoux, Nicolas, Collins, Nicholas, Han, Seong-Ji, Chen, Erin Y., Constantinides, Michael G., Link, Verena M., Lim, Ai Ing, Enamorado, Michel, Cataisson, Christophe, Gil, Louis, Rao, Indira, Farley, Taylor K., Koroleva, Galina, Attig, Jan, Yuspa, Stuart H., Fischbach, Michael A., Kassiotis, George, Belkaid, Yasmine

“…The microbiota plays a fundamental role in regulating host immunity. However, the processes involved in the initiation and regulation of immunity to the…”
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Immune checkpoint inhibitors unleash pathogenic immune responses against the microbiota by Hu, Zishuo Ian, Link, Verena M, Lima-Junior, Djalma S, Delaleu, Jérémie, Bouladoux, Nicolas, Han, Seong-Ji, Collins, Nicholas, Belkaid, Yasmine

“…Immune checkpoint inhibitors (ICIs) are essential components of the cancer therapeutic armamentarium. While ICIs have demonstrated remarkable clinical…”
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Immunity to the microbiota promotes sensory neuron regeneration by Enamorado, Michel, Kulalert, Warakorn, Han, Seong-Ji, Rao, Indira, Delaleu, Jérémie, Link, Verena M., Yong, Daniel, Smelkinson, Margery, Gil, Louis, Nakajima, Saeko, Linehan, Jonathan L., Bouladoux, Nicolas, Wlaschin, Josette, Kabat, Juraj, Kamenyeva, Olena, Deng, Liwen, Gribonika, Inta, Chesler, Alexander T., Chiu, Isaac M., Le Pichon, Claire E., Belkaid, Yasmine

“…Tissue immunity and responses to injury depend on the coordinated action and communication among physiological systems. Here, we show that, upon injury,…”
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Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function by Zhang, Yuanyue, Bailey, Jacob T., Xu, En, Singh, Kunal, Lavaert, Marieke, Link, Verena M., D’Souza, Shanti, Hafiz, Alex, Cao, Jian, Cao, Gaoyuan, Sant’Angelo, Derek B., Sun, Wei, Belkaid, Yasmine, Bhandoola, Avinash, McGavern, Dorian B., Yang, Qi

“…Increasing evidence indicates close interaction between immune cells and the brain, revising the traditional view of the immune privilege of the brain…”
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Immunity to commensal skin fungi promotes psoriasiform skin inflammation by Hurabielle, Charlotte, Link, Verena M., Bouladoux, Nicolas, Han, Seong-Ji, Merrill, Eric Dean, Lightfoot, Yaima L., Seto, Nickie, Bleck, Christopher K. E., Smelkinson, Margery, Harrison, Oliver J., Linehan, Jonathan L., Tamoutounour, Samira, Lionakis, Michail S., Kaplan, Mariana J., Nakajima, Saeko, Belkaid, Yasmine

“…Under steady-state conditions, the immune system is poised to sense and respond to the microbiota. As such, immunity to the microbiota, including T cell…”
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Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function by Link, Verena M., Duttke, Sascha H., Chun, Hyun B., Holtman, Inge R., Westin, Emma, Hoeksema, Marten A., Abe, Yohei, Skola, Dylan, Romanoski, Casey E., Tao, Jenhan, Fonseca, Gregory J., Troutman, Ty D., Spann, Nathanael J., Strid, Tobias, Sakai, Mashito, Yu, Miao, Hu, Rong, Fang, Rongxin, Metzler, Dirk, Ren, Bing, Glass, Christopher K.

“…Non-coding genetic variation is a major driver of phenotypic diversity and allows the investigation of mechanisms that control gene expression. Here, we…”
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