Search Results - "Link, C. D"

Mechanisms of G-CSF-mediated hematopoietic stem and progenitor mobilization by Greenbaum, A M, Link, D C

“…Under normal conditions, the great majority of hematopoietic stem/progenitors cells (HSPCs) reside in the bone marrow. The number of HSPCs in the circulation…”
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Clonal diversity of recurrently mutated genes in myelodysplastic syndromes by Walter, M J, Shen, D, Shao, J, Ding, L, White, B S, Kandoth, C, Miller, C A, Niu, B, McLellan, M D, Dees, N D, Fulton, R, Elliot, K, Heath, S, Grillot, M, Westervelt, P, Link, D C, DiPersio, J F, Mardis, E, Ley, T J, Wilson, R K, Graubert, T A

“…Recent studies suggest that most cases of myelodysplastic syndrome (MDS) are clonally heterogeneous, with a founding clone and multiple subclones. It is not…”
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Invertebrate models of Alzheimer's disease by Link, C. D.

“…The intensely studied model organisms Caenorhabditis elegans and Drosophila melanogaster have been employed to study a number of neurodegenerative diseases,…”
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Expression of Human β-Amyloid Peptide in Transgenic Caenorhabditis elegans by Link, Christopher D.

“…Transgenic Caenorhabditis elegans nematodes have been engineered to express potentially amyloidic human proteins. These animals contain constructs in which the…”
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‘CHIP’ping away at clonal hematopoiesis by Link, D C, Walter, M J

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Transgenic invertebrate models of age-associated neurodegenerative diseases by Link, Christopher D

“…Transgenic Drosophila melanogaster and Caenorhabditis elegans strains have been engineered to express human proteins associated with neurodegenerative…”
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Alzheimer's disease drug discovery: in vivo screening using Caenorhabditis elegans as a model for β-amyloid peptide-induced toxicity by Lublin, A.L., Link, C.D.

“…Alzheimer's disease (AD) is a complex human neurodegenerative disease. Currently the therapeutics for AD only treats the symptoms. While numbers of excellent…”
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G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling by Schuettpelz, L G, Borgerding, J N, Christopher, M J, Gopalan, P K, Romine, M P, Herman, A C, Woloszynek, J R, Greenbaum, A M, Link, D C

“…Recent studies demonstrate that inflammatory signals regulate hematopoietic stem cells (HSCs). Granulocyte colony-stimulating factor (G-CSF) is often induced…”
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Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy by Uy, G L, Duncavage, E J, Chang, G S, Jacoby, M A, Miller, C A, Shao, J, Heath, S, Elliott, K, Reineck, T, Fulton, R S, Fronick, C C, O'Laughlin, M, Ganel, L, Abboud, C N, Cashen, A F, DiPersio, J F, Wilson, R K, Link, D C, Welch, J S, Ley, T J, Graubert, T A, Westervelt, P, Walter, M J

“…Traditional response criteria in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are based on bone marrow morphology and may not accurately…”
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In Vivo Aggregation of β‐Amyloid Peptide Variants by Fay, David S., Fluet, Amy, Johnson, Carolyn J., Link, Christopher D.

“…: Transgenic Caenorhabditis elegans animals have been engineered to express wild‐type and single‐amino acid variants of a long form of human β‐amyloid peptide…”
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STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils by Panopoulos, Athanasia D., Zhang, Ling, Snow, Jonathan W., Jones, Daniel M., Smith, Amber M., El Kasmi, Karim C., Liu, Fulu, Goldsmith, Mark A., Link, Daniel C., Murray, Peter J., Watowich, Stephanie S.

“…Granulocyte colony-stimulating factor (G-CSF) is essential for the host response to bacterial infection by controlling neutrophil production in the bone…”
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Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing by Young, A L, Wong, T N, Hughes, A E O, Heath, S E, Ley, T J, Link, D C, Druley, T E

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Oxidative stress precedes fibrillar deposition of Alzheimer’s disease amyloid β-peptide (1–42) in a transgenic Caenorhabditis elegans model by Drake, Jennifer, Link, Christopher D, Butterfield, D.Allan

“…Alzheimer’s disease is a progressive, neurodegenerative disorder characterized by senile plaques and neurofibrillary components. Aβ(1–42) is a principal…”
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G-CSF Is an Essential Regulator of Neutrophil Trafficking from the Bone Marrow to the Blood by Semerad, Craig L, Liu, Fulu, Gregory, Alyssa D, Stumpf, Katherine, Link, Daniel C

“…Neutrophils are released from the bone marrow in a regulated fashion to maintain homeostatic levels in the blood and to respond to physiological stresses,…”
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Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer’s disease model by Link, Christopher D, Taft, Andrew, Kapulkin, Vadim, Duke, Kyle, Kim, Stuart, Fei, Qing, Wood, Douglas E, Sahagan, Barbara G

“…We have engineered transgenic Caenorhabditis elegans animals to inducibly express the human beta amyloid peptide (Aβ). Gene expression changes resulting from…”
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The characterization of the Caenorhabditis elegans mitochondrial thioredoxin system uncovers an unexpected protective role of thioredoxin reductase 2 in β-amyloid peptide toxicity by Cacho-Valadez, Briseida, Muñoz-Lobato, Fernando, Pedrajas, José Rafael, Cabello, Juan, Fierro-González, Juan Carlos, Navas, Plácido, Swoboda, Peter, Link, Chris D, Miranda-Vizuete, Antonio

“…Functional in vivo studies on the mitochondrial thioredoxin system are hampered by the embryonic or larval lethal phenotypes displayed by murine or Drosophila…”
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A global analysis of Caenorhabditis elegans operons by Blumenthal, Thomas, Evans, Donald, Link, Christopher D, Guffanti, Alessandro, Lawson, Daniel, Thierry-Mieg, Jean, Thierry-Mieg, Danielle, Chiu, Wei Lu, Duke, Kyle, Kiraly, Moni, Kim, Stuart K

“…The nematode worm Caenorhabditis elegans and its relatives are unique among animals in having operons. Operons are regulated multigene transcription units, in…”
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Characterization of Caenorhabditis elegans Lectin-Binding Mutants by Link, C. D, Silverman, M. A, Breen, M, Watt, K. E, Dames, S. A

“…We have identified 45 mutants of Caenorhabditis elegans that show ectopic surface binding of the lectins wheat germ agglutinin (WGA) and soybean agglutinin…”
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In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42) by Yatin, S M, Varadarajan, S, Link, C D, Butterfield, D A

“…The amyloid beta-peptide (A beta)-associated free radical oxidative stress model for neuronal death in Alzheimer's disease (AD) brain predicts that neuronal…”
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Suppression of Apoptosis During Cytokine Deprivation of 32D Cells Is Not Sufficient To Induce Complete Granulocytic Differentiation by Rodel, Jill E., Link, Daniel C.

“…The role of cytokines in the control of hematopoietic cell differentiation remains controversial. Two general models for the cytokine control of hematopoietic…”
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