Search Results - "Link, Alexander"

MicroRNAs as non-invasive diagnostic biomarkers for gastric cancer: Current insights and future perspectives by Link, Alexander, Kupcinskas, Juozas

“…Non-invasive diagnostic biomarkers may contribute to an early identification of gastric cancer (GC) and improve the clinical management. Unfortunately, no…”
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Circulating and Fecal microRNAs as Biomarkers for Inflammatory Bowel Diseases by Schönauen, Katharina, Le, Nha, von Arnim, Ulrike, Schulz, Christian, Malfertheiner, Peter, Link, Alexander

“…Abstract Background Assessment of the disease activity in inflammatory bowel disease (IBD) is essential for adequate treatment management and reliable…”
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Epigenetic Silencing of miR-137 Is an Early Event in Colorectal Carcinogenesis by BALAGUER, Francesc, LINK, Alexander, JOSE LOZANO, Juan, CUATRECASAS, Miriam, NAGASAKA, Takeshi, BOLAND, C. Richard, GOEL, Ajay

“…Global downregulation of microRNAs (miRNA) is a common feature in colorectal cancer (CRC). Whereas CpG island hypermethylation constitutes a mechanism for…”
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Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening by LINK, Alexander, BALAGUER, Francesc, YAN SHEN, NAGASAKA, Takeshi, LOZANO, Juan José, BOLAND, C. Richard, GOEL, Ajay

“…Colorectal cancer (CRC) is the second leading cause of cancer-related deaths, but currently available noninvasive screening programs have achieved only a…”
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Feasibility of fecal microRNAs as novel biomarkers for pancreatic cancer by Link, Alexander, Becker, Verena, Goel, Ajay, Wex, Thomas, Malfertheiner, Peter

“…Pancreatic cancer (PCA) is an aggressive tumor that associates with high mortality rates. Majority of PCA patients are diagnosed usually at late tumor stages…”
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Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer by Lehr, Konrad, Nikitina, Darja, Vilchez-Vargas, Ramiro, Steponaitiene, Ruta, Thon, Cosima, Skieceviciene, Jurgita, Schanze, Denny, Zenker, Martin, Malfertheiner, Peter, Kupcinskas, Juozas, Link, Alexander

“…Helicobacter pylori ( H. pylori ) infection has been considered as the main causal factor in gastric carcinogenesis, but other bacterial species may also play…”
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Curcumin modulates DNA methylation in colorectal cancer cells by Link, Alexander, Balaguer, Francesc, Shen, Yan, Lozano, Juan Jose, Leung, Hon-Chiu E, Boland, C Richard, Goel, Ajay

“…Recent evidence suggests that several dietary polyphenols may exert their chemopreventive effect through epigenetic modifications. Curcumin is one of the most…”
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Food‐Derived Xeno‐microRNAs: Influence of Diet and Detectability in Gastrointestinal Tract—Proof‐of‐Principle Study by Link, Jastin, Thon, Cosima, Schanze, Denny, Steponaitiene, Ruta, Kupcinskas, Juozas, Zenker, Martin, Canbay, Ali, Malfertheiner, Peter, Link, Alexander

“…Scope Diet is amongst the most crucial factors contributing to the multistep process of carcinogenesis. The role of exogenous microRNAs (miRNAs) is still…”
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Inflammatory microRNAs in gastric mucosa are modulated by Helicobacter pylori infection and proton-pump inhibitors but not by aspirin or NSAIDs by Vasapolli, Riccardo, Venerito, Marino, Schirrmeister, Wiebke, Thon, Cosima, Weigt, Jochen, Wex, Thomas, Malfertheiner, Peter, Link, Alexander

“…Gastric carcinogenesis is associated with alterations of microRNAs (miRNAs) and reversal of these alterations may be a crucial element in cancer prevention…”
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Current biomarkers for hepatocellular carcinoma：Surveillance, diagnosis and prediction of prognosis by Schütte, Kerstin, Schulz, Christian, Link, Alexander, Malfertheiner, Peter

“…Biomarkers for surveillance, diagnosis and predictionof prognosis in patients with hepatocellular carcinoma（HCC） are currently not ready for introduction…”
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Macro-role of microRNA in gastric cancer by Link, Alexander, Kupcinskas, Juozas, Wex, Thomas, Malfertheiner, Peter

“…Gastric cancer is a heterogeneous disease with currently still unknown mechanisms of development. Besides genetic and epigenetic mechanisms, microRNAs (miRNAs)…”
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Prediction of anastomotic insufficiency based on the mucosal microbiome prior to colorectal surgery: a proof-of-principle study by Lehr, Konrad, Lange, Undine Gabriele, Hipler, Noam Mathias, Vilchez-Vargas, Ramiro, Hoffmeister, Albrecht, Feisthammel, Jürgen, Buchloh, Dorina, Schanze, Denny, Zenker, Martin, Gockel, Ines, Link, Alexander, Jansen-Winkeln, Boris

“…Anastomotic leakage (AL) is a potentially life-threatening complication following colorectal cancer (CRC) resection. In this study, we aimed to unravel…”
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miR-20b and miR-451a Are Involved in Gastric Carcinogenesis through the PI3K/AKT/mTOR Signaling Pathway: Data from Gastric Cancer Patients, Cell Lines and Ins-Gas Mouse Model by Streleckiene, Greta, Inciuraite, Ruta, Juzenas, Simonas, Salteniene, Violeta, Steponaitiene, Ruta, Gyvyte, Ugne, Kiudelis, Gediminas, Leja, Marcis, Ruzgys, Paulius, Satkauskas, Saulius, Kupcinskiene, Eugenija, Franke, Sabine, Thon, Cosima, Link, Alexander, Kupcinskas, Juozas, Skieceviciene, Jurgita

“…Gastric cancer (GC) is one of the most common and lethal gastrointestinal malignancies worldwide. Many studies have shown that development of GC and other…”
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Primers matter: Influence of the primer selection on human fungal detection using high throughput sequencing by Wiesmann, Crispin, Lehr, Konrad, Kupcinskas, Juozas, Vilchez-Vargas, Ramiro, Link, Alexander

“…Microbiota research has received an increasing attention for its role in disease development and fungi are considered as one of the key players in the…”
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Profiling of the Bacterial Microbiota along the Murine Alimentary Tract by Vilchez-Vargas, Ramiro, Salm, Franz, Znalesniak, Eva B, Haupenthal, Katharina, Schanze, Denny, Zenker, Martin, Link, Alexander, Hoffmann, Werner

“…Here, the spatial distribution of the bacterial flora along the murine alimentary tract was evaluated using high throughput sequencing in wild-type and…”
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Identification of long intergenic non-coding RNAs (lincRNAs) deregulated in gastrointestinal stromal tumors (GISTs) by Gyvyte, Ugne, Kupcinskas, Juozas, Juzenas, Simonas, Inciuraite, Ruta, Poskiene, Lina, Salteniene, Violeta, Link, Alexander, Fassan, Matteo, Franke, Andre, Kupcinskas, Limas, Skieceviciene, Jurgita

“…Long intergenic non-coding RNAs (lincRNAs) are >200 nucleotides long non-coding RNAs, which have been shown to be implicated in carcinogenic processes by…”
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Improvement of daratumumab- or elotuzumab-mediated NK cell activity by the bi-specific 4-1BB agonist, DARPin α-FAPx4–1BB: A preclinical study in multiple myeloma by Saltarella, Ilaria, Link, Alexander, Lamanuzzi, Aurelia, Reichen, Christian, Robinson, Joanna, Altamura, Concetta, Melaccio, Assunta, Solimando, Antonio Giovanni, Ria, Roberto, Mariggiò, Maria Addolorata, Vacca, Angelo, Frassanito, Maria Antonia, Desaphy, Jean-François

“…Multiple myeloma (MM) progression is closely dependent on cells in the bone marrow (BM) microenvironment, including fibroblasts (FBs) and immune cells. In…”
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Gene polymorphisms of micrornas in Helicobacter pylori-induced high risk atrophic gastritis and gastric cancer by Kupcinskas, Juozas, Wex, Thomas, Link, Alexander, Leja, Marcis, Bruzaite, Indre, Steponaitiene, Ruta, Juzenas, Simonas, Gyvyte, Ugne, Ivanauskas, Audrius, Ancans, Guntis, Petrenkiene, Vitalija, Skieceviciene, Jurgita, Kupcinskas, Limas, Malfertheiner, Peter

“…MicroRNAs (miRNAs) are known for their function as translational regulators of tumor suppressor or oncogenes. Single nucleotide polymorphisms (SNPs) in miRNAs…”
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Analysis of Deregulated microRNAs and Their Target Genes in Gastric Cancer by Juzėnas, Simonas, Saltenienė, Violeta, Kupcinskas, Juozas, Link, Alexander, Kiudelis, Gediminas, Jonaitis, Laimas, Jarmalaite, Sonata, Kupcinskas, Limas, Malfertheiner, Peter, Skieceviciene, Jurgita

“…MicroRNAs (miRNAs) are widely studied non-coding RNAs that modulate gene expression. MiRNAs are deregulated in different tumors including gastric cancer (GC)…”
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Epigenetic silencing of miR-137 is a frequent event in gastric carcinogenesis by Steponaitiene, Ruta, Kupcinskas, Juozas, Langner, Cosima, Balaguer, Francesc, Venclauskas, Linas, Pauzas, Henrikas, Tamelis, Algimantas, Skieceviciene, Jurgita, Kupcinskas, Limas, Malfertheiner, Peter, Link, Alexander

“…MicroRNAs (miRNA) are involved in posttranscriptional regulation of gene expression and are dysregulated during carcinogenesis. CpG island methylation of…”
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