Search Results - "Linhardt, Robert J."

Chemoenzymatic synthesis of heparan sulfate and heparin by Liu, Jian, Linhardt, Robert J

“…Heparan sulfate is a polysaccharide that plays essential physiological functions in the animal kingdom. Heparin, a highly sulfated form of heparan sulfate, is…”
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Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review by Lu, Jiahui, He, Rongjun, Sun, Peilong, Zhang, Fuming, Linhardt, Robert J., Zhang, Anqiang

“…Ganoderma lucidum, commonly known as “Lingzhi” in Chinese, are well-known medicinal mushrooms. Lingzhi has been used in traditional Chinese herbal medicines…”
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Analysis of the Glycosaminoglycan Chains of Proteoglycans by Song, Yuefan, Zhang, Fuming, Linhardt, Robert J.

“…Glycosaminoglycans (GAGs) are heterogeneous, negatively charged, macromolecules that are found in animal tissues. Based on the form of component sugar, GAGs…”
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Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions by Kim, So Young, Jin, Weihua, Sood, Amika, Montgomery, David W., Grant, Oliver C., Fuster, Mark M., Fu, Li, Dordick, Jonathan S., Woods, Robert J., Zhang, Fuming, Linhardt, Robert J.

“…Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a pandemic and continues to spread around the globe at an unprecedented…”
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Rethinking the impact of RG-I mainly from fruits and vegetables on dietary health by Wu, Dongmei, Zheng, Jiaqi, Mao, Guizhu, Hu, Weiwei, Ye, Xingqian, Linhardt, Robert J., Chen, Shiguo

“…Rhamnogalacturonan I (RG-I) pectin is composed of backbone of repeating disaccharide units →2)-α-L-Rhap-(1→4)-α-D-GalpA-(1→ and neutral sugar side-chains…”
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Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives by Tandon, Ritesh, Sharp, Joshua S, Zhang, Fuming, Pomin, Vitor H, Ashpole, Nicole M, Mitra, Dipanwita, McCandless, Martin G, Jin, Weihua, Liu, Hao, Sharma, Poonam, Linhardt, Robert J

“…Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused a pandemic of historic proportions and continues to spread globally, with…”
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Glycosaminoglycans in infectious disease by Kamhi, Eyal, Joo, Eun Ji, Dordick, Jonathan S., Linhardt, Robert J.

“…ABSTRACT Glycosaminoglycans (GAGs) are complex carbohydrates that are ubiquitously present on the cell surface and in the extracellular matrix. Interactions…”
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Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis by Lee, Sang Hyun, Doherty, Thomas V, Linhardt, Robert J, Dordick, Jonathan S

“…Lignocellulose represents a key sustainable source of biomass for transformation into biofuels and bio-based products. Unfortunately, lignocellulosic biomass…”
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Room temperature ionic liquids as emerging solvents for the pretreatment of lignocellulosic biomass by Mora-Pale, Mauricio, Meli, Luciana, Doherty, Thomas V., Linhardt, Robert J., Dordick, Jonathan S.

“…Room temperature ionic liquids (RTILs) are emerging as attractive and green solvents for lignocellulosic biomass pretreatment. The unique solvating properties…”
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Structure, bioactivities and applications of the polysaccharides from Tremella fuciformis mushroom: A review by Wu, Yu-ji, Wei, Zheng-xun, Zhang, Fu-ming, Linhardt, Robert J., Sun, Pei-long, Zhang, An-qiang

“…Tremella fuciformis is an important edible mushroom that has been widely cultivated and used as food and medicinal ingredient in traditional Chinese medicine…”
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The Application of Seaweed Polysaccharides and Their Derived Products with Potential for the Treatment of Alzheimer's Disease by Bauer, Sarah, Jin, Weihua, Zhang, Fuming, Linhardt, Robert J

“…Neurodegenerative diseases are among the most widespread diseases affecting humans, and the number of patients is only rising. Seaweed polysaccharide extracts…”
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Comparison of the Interactions of Different Growth Factors and Glycosaminoglycans by Zhang, Fuming, Zheng, Lanhong, Cheng, Shuihong, Peng, Yanfei, Fu, Li, Zhang, Xing, Linhardt, Robert J

“…Most growth factors are naturally occurring proteins, which are signaling molecules implicated in cellular multiple functions such as proliferation, migration…”
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Heparin: Past, Present, and Future by Oduah, Eziafa I, Linhardt, Robert J, Sharfstein, Susan T

“…Heparin, the most widely used anticoagulant drug in the world today, remains an animal-derived product with the attendant risks of adulteration and…”
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Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins by Xu, Yongmei, Masuko, Sayaka, Takieddin, Majde, Xu, Haoming, Liu, Renpeng, Jing, Juliana, Mousa, Shaker A., Linhardt, Robert J., Liu, Jian

“…Ultralow molecular weight (ULAAW) heparins are sulfated glycans that are clinically used to treat thrombotic disorders. ULMW heparins range from 1500 to 3000…”
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Masquerading microbial pathogens: capsular polysaccharides mimic host-tissue molecules by Cress, Brady F., Englaender, Jacob A., He, Wenqin, Kasper, Dennis, Linhardt, Robert J., Koffas, Mattheos A.G.

“…Abstract The increasing prevalence of antibiotic-resistant bacteria portends an impending postantibiotic age, characterized by diminishing efficacy of common…”
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Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation by Hippensteel, Joseph A, Uchimido, Ryo, Tyler, Patrick D, Burke, Ryan C, Han, Xiaorui, Zhang, Fuming, McMurtry, Sarah A, Colbert, James F, Lindsell, Christopher J, Angus, Derek C, Kellum, John A, Yealy, Donald M, Linhardt, Robert J, Shapiro, Nathan I, Schmidt, Eric P

“…Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models…”
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Top-Down Approach for the Direct Characterization of Low Molecular Weight Heparins Using LC-FT-MS by Li, Lingyun, Zhang, Fuming, Zaia, Joseph, Linhardt, Robert J

“…Low molecular heparins (LMWHs) are structurally complex, heterogeneous, polydisperse, and highly negatively charged mixtures of polysaccharides. The direct…”
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An 'omics approach towards CHO cell engineering by Datta, Payel, Linhardt, Robert J., Sharfstein, Susan T.

“…Chinese hamster ovarian cells (CHO) cells have been extensively utilized for industrial production of biopharmaceutical products, such as monoclonal…”
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Extraction Methods Affect the Structure of Goji ( Lycium barbarum ) Polysaccharides by Zhou, Shengyi, Rahman, Atikur, Li, Junhui, Wei, Chaoyang, Chen, Jianle, Linhardt, Robert J, Ye, Xingqian, Chen, Shiguo

“…Polysaccharides are considered to be the most important active substances in Goji. However, the structure of polysaccharides varies according to the extraction…”
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Nanostructured glycan architecture is important in the inhibition of influenza A virus infection by Kwon, Seok-Joon, Na, Dong Hee, Kwak, Jong Hwan, Douaisi, Marc, Zhang, Fuming, Park, Eun Ji, Park, Jong-Hwan, Youn, Hana, Song, Chang-Seon, Kane, Ravi S., Dordick, Jonathan S., Lee, Kyung Bok, Linhardt, Robert J.

“…6’-Sialyllactose conjugated to polyamidoamine dendrimers at a well-defined valency and spacing can circumvent drug resistance and inhibit influenza A viruses…”
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