Search Results - "Lingrel, Jerry"

The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na,K-ATPase by Lingrel, Jerry B

“…The Na,K-ATPase is the membrane "pump" that generates the Na(+) and K(+) gradients across the plasma membrane that drives many physiological processes. This…”
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Na,K-ATPase α2 activity in mammalian skeletal muscle T-tubules is acutely stimulated by extracellular K by DiFranco, Marino, Hakimjavadi, Hesamedin, Lingrel, Jerry B, Heiny, Judith A

“…The Na,K-ATPase α2 isoform is the predominant Na,K-ATPase in adult skeletal muscle and the sole Na,K-ATPase in the transverse tubules (T-tubules). In quiescent…”
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The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock by Mahabeleshwar, Ganapati H., Kawanami, Daiji, Sharma, Nikunj, Takami, Yoichi, Zhou, Guangjin, Shi, Hong, Nayak, Lalitha, Jeyaraj, Darwin, Grealy, Robert, White, Mary, McManus, Ross, Ryan, Thomas, Leahy, Patrick, Lin, Zhiyong, Haldar, Saptarsi M., Atkins, G. Brandon, Wong, Hector R., Lingrel, Jerry B., Jain, Mukesh K.

“…Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent…”
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Na+/K+-ATPase α2-isoform preferentially modulates Ca2+ transients and sarcoplasmic reticulum Ca2+ release in cardiac myocytes by DESPA, Sanda, LINGREL, Jerry B, BERS, Donald M

“…Na(+)/K(+)-ATPase (NKA) is essential in regulating [Na(+)](i), and thus cardiac myocyte Ca(2+) and contractility via Na(+)/Ca(2+) exchange. Different NKA-α…”
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Na+/Ca2+ exchange and Na+/K+‐ATPase in the heart by Shattock, Michael J., Ottolia, Michela, Bers, Donald M., Blaustein, Mordecai P., Boguslavskyi, Andrii, Bossuyt, Julie, Bridge, John H. B., Chen‐Izu, Ye, Clancy, Colleen E., Edwards, Andrew, Goldhaber, Joshua, Kaplan, Jack, Lingrel, Jerry B., Pavlovic, Davor, Philipson, Kenneth, Sipido, Karin R., Xie, Zi‐Jian

“…This paper is the third in a series of reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems…”
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An α2-Na/K ATPase/α-adducin complex in astrocytes triggers non–cell autonomous neurodegeneration by Gallardo, Gilbert, Barowski, Jessica, Ravits, John, Siddique, Teepu, Lingrel, Jerry B, Robertson, Janice, Steen, Hanno, Bonni, Azad

“…It has been suggested that astrocytes play a role in the onset and progression of neurodegenerative disorders such as ALS. In this study, the authors show that…”
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An alpha 2-Na/K ATPase/ alpha -adducin complex in astrocytes triggers non-cell autonomous neurodegeneration by Gallardo, Gilbert, Barowski, Jessica, Ravits, John, Siddique, Teepu, Lingrel, Jerry B, Robertson, Janice, Steen, Hanno, Bonni, Azad

“…Perturbations of astrocytes trigger neurodegeneration in several diseases, but the glial cell-intrinsic mechanisms that induce neurodegeneration remain poorly…”
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Pivotal role of α2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease by Blaustein, Mordecai P., Chen, Ling, Hamlyn, John M., Leenen, Frans H. H., Lingrel, Jerry B., Wier, W. Gil, Zhang, Jin

“…Reduced smooth muscle (SM)‐specific α2 Na+ pump expression elevates basal blood pressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and…”
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Reduced Levels of microRNAs miR-124a and miR-150 Are Associated with Increased Proinflammatory Mediator Expression in Krüppel-like Factor 2 (KLF2)-deficient Macrophages by Manoharan, Palanikumar, Basford, Joshua E., Pilcher-Roberts, Robyn, Neumann, Jonathan, Hui, David Y., Lingrel, Jerry B.

“…Previous studies have shown that the myeloid-specific deficiency of the transcription factor Krüppel-like factor 2 (KLF2) accelerates atherosclerosis in…”
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Genetic Reduction of the α1 Subunit of Na/K-ATPase Corrects Multiple Hippocampal Phenotypes in Angelman Syndrome by Kaphzan, Hanoch, Buffington, Shelly A., Ramaraj, Akila B., Lingrel, Jerry B., Rasband, Matthew N., Santini, Emanuela, Klann, Eric

“…Angelman syndrome (AS) is associated with symptoms that include autism, intellectual disability, motor abnormalities, and epilepsy. We recently showed that AS…”
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Tissue-specific Role of the Na,K-ATPase α2 Isozyme in Skeletal Muscle by Radzyukevich, Tatiana L., Neumann, Jonathon C., Rindler, Tara N., Oshiro, Naomi, Goldhamer, David J., Lingrel, Jerry B., Heiny, Judith A.

“…The Na,K-ATPase α2 isozyme is the major Na,K-ATPase of mammalian skeletal muscle. This distribution is unique compared with most other cells, which express…”
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K⁺ and Rb⁺ Affinities of the Na,K-ATPase α₁ and α₂ Isozymes: An Application of ICP-MS for Quantification of Na⁺ Pump Kinetics in Myofibers by Hakimjavadi, Hesamedin, Stiner, Cory A, Radzyukevich, Tatiana L, Lingrel, Jerry B, Norman, Natalie, Landero Figueroa, Julio A, Heiny, Judith A

“…The potassium affinities of Na,K-ATPase isozymes are important determinants of their physiological roles in skeletal muscle. This study measured the apparent…”
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Kruppel-like factor 2 regulates thymocyte and T-cell migration by Hogquist, Kristin A, Jameson, Stephen C, Carlson, Corey M, Endrizzi, Bart T, Wu, Jinghai, Ding, Xiaojie, Weinreich, Michael A, Walsh, Elizabeth R, Wani, Maqsood A, Lingrel, Jerry B

“…Mammalian Kruppel-like transcription factors are implicated in regulating terminal differentiation of several tissue types. Deficiency in Kruppel-like factor…”
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Myeloid-Specific Krüppel-Like Factor 2 Inactivation Increases Macrophage and Neutrophil Adhesion and Promotes Atherosclerosis by Lingrel, Jerry B, Pilcher-Roberts, Robyn, Basford, Joshua E, Manoharan, Palanikumar, Neumann, Jon, Konaniah, Eddy S, Srinivasan, Ramprasad, Bogdanov, Vladimir Y, Hui, David Y

“…RATIONALE:Hemizygous deficiency of the transcription factor Krüppel-like factor 2 (KLF2) has been shown previously to augment atherosclerosis in…”
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Isoform-specific role of Na/K-ATPase α1 in skeletal muscle by Kutz, Laura C, Mukherji, Shreya T, Wang, Xiaoliang, Bryant, Amber, Larre, Isabel, Heiny, Judith A, Lingrel, Jerry B, Pierre, Sandrine V, Xie, Zijian

“…The distribution of Na/K-ATPase α-isoforms in skeletal muscle is unique, with α1 as the minor (15%) isoform and α2 comprising the bulk of the Na/K-ATPase pool…”
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Cardiac Oxidative Signaling and Physiological Hypertrophy in the Na/K-ATPase α1 s/s α2 s/s Mouse Model of High Affinity for Cardiotonic Steroids by Marck, Pauline V, Pessoa, Marco T, Xu, Yunhui, Kutz, Laura C, Collins, Dominic M, Yan, Yanling, King, Cierra, Wang, Xiaoliang, Duan, Qiming, Cai, Liquan, Xie, Jeffrey X, Lingrel, Jerry B, Xie, Zijian, Tian, Jiang, Pierre, Sandrine V

“…The Na/K-ATPase is the specific receptor for cardiotonic steroids (CTS) such as ouabain and digoxin. At pharmacological concentrations used in the treatment of…”
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The α1 Isoform of Na,K-ATPase Regulates Cardiac Contractility and Functionally Interacts and Co-localizes with the Na/Ca Exchanger in Heart by Dostanic, Iva, Schultz, Jo El J., Lorenz, John N., Lingrel, Jerry B

“…The primary objective of this study was to examine the functional role of the Na,K-ATPase α1 isoform in the regulation of cardiac contractility. Previous…”
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Histone Deacetylase 9 Is a Negative Regulator of Adipogenic Differentiation by Chatterjee, Tapan K., Idelman, Gila, Blanco, Victor, Blomkalns, Andra L., Piegore, Mark G., Weintraub, Daniel S., Kumar, Santosh, Rajsheker, Srinivas, Manka, David, Rudich, Steven M., Tang, Yaoliang, Hui, David Y., Bassel-Duby, Rhonda, Olson, Eric N., Lingrel, Jerry B., Ho, Shuk-Mei, Weintraub, Neal L.

“…Differentiation of preadipocytes into mature adipocytes capable of efficiently storing lipids is an important regulatory mechanism in obesity. Here, we…”
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Characterization of Atp1a3 mutant mice as a model of rapid-onset dystonia with parkinsonism by DeAndrade, Mark P., Yokoi, Fumiaki, van Groen, Thomas, Lingrel, Jerry B., Li, Yuqing

“…▶ Atp1a3 mutant mice as a model for DYT12 dystonia, rapid-onset dystonia-parkinsonism. ▶ Motor impairment similar to other mouse dystonia models found in…”
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Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice by Moseley, Amy E, Williams, Michael T, Schaefer, Tori L, Bohanan, Cynthia S, Neumann, Jon C, Behbehani, Michael M, Vorhees, Charles V, Lingrel, Jerry B

“…Several disorders have been associated with mutations in Na,K-ATPase alpha isoforms (rapid-onset dystonia parkinsonism, familial hemiplegic migraine type-2),…”
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