Search Results - "Linge, Annett"

SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed by Digomann, David, Linge, Annett, Dubrovska, Anna

“…SLC3A2/CD98hc (solute carrier family 3 member 2) and its light chain subunits constitute the heterodimeric transmembrane complexes that mediate amino acid…”
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Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L by Nathansen, Jacqueline, Lukiyanchuk, Vasyl, Hein, Linda, Stolte, Maya-Isabel, Borgmann, Kerstin, Löck, Steffen, Kurth, Ina, Baumann, Michael, Krause, Mechthild, Linge, Annett, Dubrovska, Anna

“…Head and neck squamous cell carcinoma (HNSCC) is often being diagnosed at an advanced stage, conferring a poor prognosis. The probability of local tumor…”
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The CD98 Heavy Chain Is a Marker and Regulator of Head and Neck Squamous Cell Carcinoma Radiosensitivity by Digomann, David, Kurth, Ina, Tyutyunnykova, Anna, Chen, Oleg, Löck, Steffen, Gorodetska, Ielizaveta, Peitzsch, Claudia, Skvortsova, Ira-Ida, Negro, Giulia, Aschenbrenner, Bertram, Eisenhofer, Graeme, Richter, Susan, Heiden, Stephan, Porrmann, Joseph, Klink, Barbara, Schwager, Christian, Dowle, Adam A, Hein, Linda, Kunz-Schughart, Leoni A, Abdollahi, Amir, Lohaus, Fabian, Krause, Mechthild, Baumann, Michael, Linge, Annett, Dubrovska, Anna

“…The heavy chain of the CD98 protein (CD98hc) is encoded by the gene. Together with the light subunit LAT1, CD98hc constitutes a heterodimeric transmembrane…”
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Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models by Shahzadi, Iram, Zwanenburg, Alex, Lattermann, Annika, Linge, Annett, Baldus, Christian, Peeken, Jan C., Combs, Stephanie E., Diefenhardt, Markus, Rödel, Claus, Kirste, Simon, Grosu, Anca-Ligia, Baumann, Michael, Krause, Mechthild, Troost, Esther G. C., Löck, Steffen

“…Radiomics analyses commonly apply imaging features of different complexity for the prediction of the endpoint of interest. However, the prognostic value of…”
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HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: Results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG) by Lohaus, Fabian, Linge, Annett, Tinhofer, Inge, Budach, Volker, Gkika, Eleni, Stuschke, Martin, Balermpas, Panagiotis, Rödel, Claus, Avlar, Melanie, Grosu, Anca-Ligia, Abdollahi, Amir, Debus, Jürgen, Bayer, Christine, Belka, Claus, Pigorsch, Steffi, Combs, Stephanie E, Mönnich, David, Zips, Daniel, von Neubeck, Cläre, Baretton, Gustavo B, Löck, Steffen, Thames, Howard D, Krause, Mechthild, Baumann, Michael

“…Abstract Objective To investigate the impact of HPV status in patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received…”
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Type I conventional dendritic cells and CD8 + T cells predict favorable clinical outcome of head and neck squamous cell carcinoma patients by Kirchner, Johanna, Plesca, Ioana, Rothe, Rebecca, Resag, Antonia, Löck, Steffen, Benešová, Iva, Rupp, Luise, Linge, Annett, Wehner, Rebekka, Krause, Mechthild, Schmitz, Marc

“…Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumor entities worldwide, with human papillomavirus (HPV) infection contributing to…”
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Development and Validation of a Gene Signature for Patients with Head and Neck Carcinomas Treated by Postoperative Radio(chemo)therapy by Schmidt, Stefan, Linge, Annett, Zwanenburg, Alex, Leger, Stefan, Lohaus, Fabian, Krenn, Constanze, Appold, Steffen, Gudziol, Volker, Nowak, Alexander, von Neubeck, Cläre, Tinhofer, Inge, Budach, Volker, Sak, Ali, Stuschke, Martin, Balermpas, Panagiotis, Rödel, Claus, Bunea, Hatice, Grosu, Anca-Ligia, Abdollahi, Amir, Debus, Jürgen, Ganswindt, Ute, Belka, Claus, Pigorsch, Steffi, Combs, Stephanie E, Mönnich, David, Zips, Daniel, Baretton, Gustavo B, Buchholz, Frank, Baumann, Michael, Krause, Mechthild, Löck, Steffen

“…The aim of this study was to identify and independently validate a novel gene signature predicting locoregional tumor control (LRC) for treatment…”
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Prognostic biomarkers for the response to the radiosensitizer nimorazole combined with RCTx: a pre-clinical trial in HNSCC xenografts by Koi, Lydia, Bitto, Verena, Weise, Corina, Möbius, Lisa, Linge, Annett, Löck, Steffen, Yaromina, Ala, Besso, María José, Valentini, Chiara, Pfeifer, Manuel, Overgaard, Jens, Zips, Daniel, Kurth, Ina, Krause, Mechthild, Baumann, Michael

“…Abstract Background Tumor hypoxia is associated with resistance to radiotherapy and chemotherapy. In head and neck squamous cell carcinoma (HNSCC), nimorazole,…”
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Specific requirements for translation of biological research into clinical radiation oncology by Krause, Mechthild, Alsner, Jan, Linge, Annett, Bütof, Rebecca, Löck, Steffen, Bristow, Rob

“…Radiotherapy has been optimized over the last decades not only through technological advances, but also through the translation of biological knowledge into…”
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Integrated radiogenomics analyses allow for subtype classification and improved outcome prognosis of patients with locally advanced HNSCC by Rabasco Meneghetti, Asier, Zwanenburg, Alex, Linge, Annett, Lohaus, Fabian, Grosser, Marianne, Baretton, Gustavo B., Kalinauskaite, Goda, Tinhofer, Ingeborg, Guberina, Maja, Stuschke, Martin, Balermpas, Panagiotis, von der Grün, Jens, Ganswindt, Ute, Belka, Claus, Peeken, Jan C., Combs, Stephanie E., Böke, Simon, Zips, Daniel, Troost, Esther G. C., Krause, Mechthild, Baumann, Michael, Löck, Steffen

“…Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) may benefit from personalised treatment, requiring biomarkers that characterize…”
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Identification and Functional Validation of RAD23B as a Potential Protein in Human Breast Cancer Progression by Linge, Annett, Maurya, Priyanka, Friedrich, Katrin, Baretton, Gustavo B, Kelly, Shane, Henry, Michael, Clynes, Martin, Larkin, Annemarie, Meleady, Paula

“…Identification of protein targets that play a role in breast cancer invasion may help to understand the rapid progression of cancer and may lead to the…”
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Comparison of the composition of lymphocyte subpopulations in non-relapse and relapse patients with squamous cell carcinoma of the head and neck before, during radiochemotherapy and in the follow-up period: a multicenter prospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG) by Niu, Minli, Combs, Stephanie E, Linge, Annett, Krause, Mechthild, Baumann, Michael, Lohaus, Fabian, Ebert, Nadja, Tinhofer, Ingeborg, Budach, Volker, von der Grün, Jens, Rödel, Franz, Grosu, Anca-Ligia, Multhoff, Gabriele

“…Radiochemotherapy (RCT) has been shown to induce changes in immune cell homeostasis which might affect antitumor immune responses. In the present study, we…”
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ERCC2 gene single-nucleotide polymorphism as a prognostic factor for locally advanced head and neck carcinomas after definitive cisplatin-based radiochemotherapy by Guberina, Maja, Sak, Ali, Pöttgen, Christoph, Tinhofer-Keilholz, Ingeborg, Budach, Volker, Balermpas, Panagiotis, Von der Grün, Jens, Rödel, Claus Michael, Gkika, Eleni, Grosu, Anca-Ligia, Abdollahi, Amir, Debus, Jürgen, Belka, Claus, Pigorsch, Steffi, Combs, Stephani E., Mönnich, David, Zips, Daniel, De-Colle, Chiara, Welz, Stefan, Linge, Annett, Lohaus, Fabian, Baretton, Gustavo, Gauler, Thomas, Baumann, Michael, Krause, Mechthild, Schuler, Martin, Bankfalvi, Agnes, Höing, Benedikt, Lang, Stephan, Stuschke, Martin

“…Identifying patients with locally advanced head and neck carcinoma on high risk of recurrence after definitive concurrent radiochemotherapy is of key…”
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Correction: ERCC2 gene single-nucleotide polymorphism as a prognostic factor for locally advanced head and neck carcinomas after definitive cisplatin-based radiochemotherapy by Guberina, Maja, Sak, Ali, Pöttgen, Christoph, Tinhofer-Keilholz, Ingeborg, Budach, Volker, Balermpas, Panagiotis, Von der Grün, Jens, Rödel, Claus Michael, Gkika, Eleni, Grosu, Anca-Ligia, Abdollahi, Amir, Debus, Jürgen, Belka, Claus, Pigorsch, Steffi, Combs, Stephanie E., Mönnich, David, Zips, Daniel, De-Colle, Chiara, Welz, Stefan, Linge, Annett, Lohaus, Fabian, Baretton, Gustavo, Gauler, Thomas, Baumann, Michael, Krause, Mechthild, Schuler, Martin, Bankfalvi, Agnes, Höing, Benedikt, Lang, Stephan, Stuschke, Martin

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Immunohistochemical analyses of paraffin-embedded sections after primary surgery or trimodality treatment in esophageal carcinoma by Igbo, Benjamin Terfa, Linge, Annett, Frosch, Susanne, Suckert, Theresa, Stolz-Kieslich, Liane, Löck, Steffen, Kumaravadivel, Mani Sankari, Welsch, Thilo, Weitz, Jürgen, Sommer, Ulrich, Aust, Daniela, Troost, Esther G.C.

“…•Changes in the tumor microenvironment of esophageal cancers, both in squamous cell carcinoma and adenocarcinoma, were found when comparing tumor resection…”
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Independent validation of tumour volume, cancer stem cell markers and hypoxia-associated gene expressions for HNSCC after primary radiochemotherapy by Linge, Annett, Schmidt, Stefan, Lohaus, Fabian, Krenn, Constanze, Bandurska-Luque, Anna, Platzek, Ivan, von Neubeck, Cläre, Appold, Steffen, Nowak, Alexander, Gudziol, Volker, Buchholz, Frank, Baretton, Gustavo B., Baumann, Michael, Löck, Steffen, Krause, Mechthild

“…•Tumour volume, p16 status and N stage could be validated regarding LRC and OS.•Addition of cancer stem cell markers can further improve the baseline…”
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Definition and validation of a radiomics signature for loco-regional tumour control in patients with locally advanced head and neck squamous cell carcinoma by Rabasco Meneghetti, Asier, Zwanenburg, Alex, Leger, Stefan, Leger, Karoline, Troost, Esther G.C., Linge, Annett, Lohaus, Fabian, Schreiber, Andreas, Kalinauskaite, Goda, Tinhofer, Inge, Guberina, Nika, Guberina, Maja, Balermpas, Panagiotis, von der Grün, Jens, Ganswindt, Ute, Belka, Claus, Peeken, Jan C., Combs, Stephanie E., Böke, Simon, Zips, Daniel, Krause, Mechthild, Baumann, Michael, Löck, Steffen

“…•A prognostic signature for LRC in locally-advanced HNSCC was developed and validated.•Signature development was based on advanced machine-learning…”
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Successful immunotherapy and irradiation in a HIV-positive patient with metastatic Merkel cell carcinoma by Linge, Annett, Rauschenberg, Ricarda, Blum, Sophia, Spornraft-Ragaller, Petra, Meier, Friedegund, Troost, Esther G.C.

“…•First report on PD-L1 therapy and radiotherapy in a HIV positive patient with metastatic Merkel cell carcinoma.•The patient has been tolerated the treatments…”
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Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells by Linge, Annett, Weinhold, Karina, Bläsche, Robert, Kasper, Michael, Barth, Kathrin

“…Bleomycin is an anti-cancer drug that induces both apoptosis and senescence, two processes thought to involve caveolin-1. Here we investigate the role of…”
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Independent validation of the prognostic value of cancer stem cell marker expression and hypoxia-induced gene expression for patients with locally advanced HNSCC after postoperative radiotherapy by Linge, Annett, Löck, Steffen, Krenn, Constanze, Appold, Steffen, Lohaus, Fabian, Nowak, Alexander, Gudziol, Volker, Baretton, Gustavo B., Buchholz, Frank, Baumann, Michael, Krause, Mechthild

“…To validate the impact of HPV status, cancer stem cell (CSC) marker expression and tumour hypoxia status in patients with locally advanced head and neck…”
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