Search Results - "Lingappa, Jaisri R."

Addressing Antiretroviral Drug Resistance with Host-Targeting Drugs-First Steps towards Developing a Host-Targeting HIV-1 Assembly Inhibitor by Lingappa, Jaisri R, Lingappa, Vishwanath R, Reed, Jonathan C

“…The concerning increase in HIV-1 resistance argues for prioritizing the development of host-targeting antiviral drugs because such drugs can offer high genetic…”
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Identifying the assembly intermediate in which Gag first associates with unspliced HIV-1 RNA suggests a novel model for HIV-1 RNA packaging by Barajas, Brook C, Tanaka, Motoko, Robinson, Bridget A, Phuong, Daryl J, Chutiraka, Kasana, Reed, Jonathan C, Lingappa, Jaisri R

“…During immature capsid assembly, HIV-1 genome packaging is initiated when Gag first associates with unspliced HIV-1 RNA by a poorly understood process…”
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Mutations of Conserved Residues in the Major Homology Region Arrest Assembling HIV-1 Gag as a Membrane-Targeted Intermediate Containing Genomic RNA and Cellular Proteins by Tanaka, Motoko, Robinson, Bridget A, Chutiraka, Kasana, Geary, Clair D, Reed, Jonathan C, Lingappa, Jaisri R

“…The major homology region (MHR) is a highly conserved motif that is found within the Gag protein of all orthoretroviruses and some retrotransposons. While it…”
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Host–rabies virus protein–protein interactions as druggable antiviral targets by Lingappa, Usha F, Wu, Xianfu, Macieik, Amanda, Yu, Shao Feng, Atuegbu, Andy, Corpuz, Michael, Francis, Jean, Nichols, Christine, Calayag, Alfredo, Shi, Hong, Ellison, James A, Harrell, Emma K T, Asundi, Vinod, Lingappa, Jaisri R, Prasad, M Dharma, Lipkin, W Ian, Dey, Debendranath, Hurt, Clarence R, Lingappa, Vishwanath R, Hansen, William J, Rupprecht, Charles E

“…We present an unconventional approach to antiviral drug discovery, which is used to identify potent small molecules against rabies virus. First, we…”
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HIV Gag-Leucine Zipper Chimeras Form ABCE1-Containing Intermediates and RNase-Resistant Immature Capsids Similar to Those Formed by Wild-Type HIV-1 Gag by KLEIN, Kevin C, REED, Jonathan C, TANAKA, Motoko, NGUYEN, Veronica T, GIRI, Samina, LINGAPPA, Jaisri R

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Basic Residues in the Nucleocapsid Domain of Gag Are Required for Interaction of HIV-1 Gag with ABCE1 (HP68), a Cellular Protein Important for HIV-1 Capsid Assembly by Lingappa, Jaisri R., Dooher, Julia E., Newman, Michael A., Kiser, Patti K., Klein, Kevin C.

“…During human immunodeficiency virus, type 1 (HIV-1) assembly, Gag polypeptides multimerize into immature HIV-1 capsids. The cellular ATP-binding protein ABCE1…”
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Identification of a host protein essential for assembly of immature HIV-1 capsids by Lingappa, Jaisri R, Zimmerman, Concepcion, Klein, Kevin C, Kiser, Patti K, Singh, Aalok R, Firestein, Bonnie L, Riba, Shannyn C

“…To form an immature HIV-1 capsid, 1,500 HIV-1 Gag (p55) polypeptides must assemble properly along the host cell plasma membrane. Insect cells and many higher…”
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Conservation of a Stepwise, Energy-Sensitive Pathway Involving HP68 for Assembly of Primate Lentivirus Capsids in Cells by DOOHER, Julia E, LINGAPPA, Jaisri R

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Unique Features of Hepatitis C Virus Capsid Formation Revealed by De Novo Cell-Free Assembly by KLEIN, Kevin C, POLYAK, Stephen J, LINGAPPA, Jaisri R

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Identification of Residues in the Hepatitis C Virus Core Protein That Are Critical for Capsid Assembly in a Cell-Free System by KLEIN, Kevin C, DELLOS, Sheri R, LINGAPPA, Jaisri R

“…Erratum ( vol. 79 , p. 10098 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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T cells contain an RNase-insensitive inhibitor of APOBEC3G deaminase activity by Thielen, Beth K, Klein, Kevin C, Walker, Lorne W, Rieck, Mary, Buckner, Jane H, Tomblingson, Garrett W, Lingappa, Jaisri R

“…The deoxycytidine deaminase APOBEC3G (A3G) is expressed in human T cells and inhibits HIV-1 replication. When transfected into A3G-deficient epithelial cell…”
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Identification of an Antiretroviral Small Molecule That Appears To Be a Host-Targeting Inhibitor of HIV-1 Assembly by Reed, Jonathan C, Solas, Dennis, Kitaygorodskyy, Anatoliy, Freeman, Beverly, Ressler, Dylan T B, Phuong, Daryl J, Swain, J Victor, Matlack, Kent, Hurt, Clarence R, Lingappa, Vishwanath R, Lingappa, Jaisri R

“…Given the projected increase in multidrug-resistant HIV-1, there is an urgent need for development of antiretrovirals that act on virus life cycle stages not…”
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HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly by Reed, Jonathan C, Molter, Britta, Geary, Clair D, McNevin, John, McElrath, Julie, Giri, Samina, Klein, Kevin C, Lingappa, Jaisri R

“…To produce progeny virus, human immunodeficiency virus type I (HIV-1) Gag assembles into capsids that package the viral genome and bud from the infected cell…”
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Antiviral Function of APOBEC3G Can Be Dissociated from Cytidine Deaminase Activity by Newman, Edmund N.C., Holmes, Rebecca K., Craig, Heather M., Klein, Kevin C., Lingappa, Jaisri R., Malim, Michael H., Sheehy, Ann M.

“…The antiretroviral activity of the cellular enzyme APOBEC3G [1] has been attributed to the excessive deamination of cytidine (C) to uridine (U) in minus strand…”
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Innate Immune Signaling Induces High Levels of TC-specific Deaminase Activity in Primary Monocyte-derived Cells through Expression of APOBEC3A Isoforms by Thielen, Beth K., McNevin, John P., McElrath, M. Juliana, Hunt, Brook Vander Stoep, Klein, Kevin C., Lingappa, Jaisri R.

“…In HIV-1-infected individuals, G-to-A hypermutation is found in HIV-1 DNA isolated from peripheral blood mononuclear cells (PBMCs). These mutations are thought…”
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A temporospatial map that defines specific steps at which critical surfaces in the Gag MA and CA domains act during immature HIV-1 capsid assembly in cells by Robinson, Bridget A, Reed, Jonathan C, Geary, Clair D, Swain, J Victor, Lingappa, Jaisri R

“…During HIV-1 assembly, Gag polypeptides target to the plasma membrane, where they multimerize to form immature capsids that undergo budding and maturation…”
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Formation of RNA Granule-Derived Capsid Assembly Intermediates Appears To Be Conserved between Human Immunodeficiency Virus Type 1 and the Nonprimate Lentivirus Feline Immunodeficiency Virus by Reed, Jonathan C, Westergreen, Nick, Barajas, Brook C, Ressler, Dylan T B, Phuong, Daryl J, Swain, John V, Lingappa, Vishwanath R, Lingappa, Jaisri R

“…During immature capsid assembly in cells, human immunodeficiency virus type 1 (HIV-1) Gag co-opts a host RNA granule, forming a pathway of intracellular…”
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Limited recovery of pineal function after regeneration of preganglionic sympathetic axons: evidence for loss of ganglionic synaptic specificity by Lingappa, Jaisri R, Zigmond, Richard E

“…The cervical sympathetic trunks (CSTs) contain axons of preganglionic neurons that innervate the superior cervical ganglia (SCGs). Because regeneration of CST…”
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How HIV-1 Gag assembles in cells: Putting together pieces of the puzzle by Lingappa, Jaisri R., Reed, Jonathan C., Tanaka, Motoko, Chutiraka, Kasana, Robinson, Bridget A.

“…•Various experimental approaches have shaped our understanding of HIV-1 assembly.•Here we describe complementary findings obtained with these approaches.•Major…”
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Host ABCE1 is at Plasma Membrane HIV Assembly Sites and Its Dissociation from Gag is Linked to Subsequent Events of Virus Production by Dooher, Julia E., Schneider, Bobbie L., Reed, Jonathan C., Lingappa, Jaisri R.

“…In primate cells, assembly of a single HIV‐1 capsid involves multimerization of thousands of Gag polypeptides, typically at the plasma membrane. Although…”
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