Search Results - "Ling, Z D"

6-Hydroxydopamine-induced alterations in blood-brain barrier permeability by Carvey, P. M., Zhao, C. H., Hendey, B., Lum, H., Trachtenberg, J., Desai, B. S., Snyder, J., Zhu, Y. G., Ling, Z. D.

“…Vascular inflammation is well known for its ability to compromise the function of the blood–brain barrier (BBB). Whether inflammation on the parenchymal side…”
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Combined toxicity of prenatal bacterial endotoxin exposure and postnatal 6-hydroxydopamine in the adult rat midbrain by Ling, Z.D, Chang, Q, Lipton, J.W, Tong, C.W, Landers, T.M, Carvey, P.M

“…We previously reported that injection of the Gram (−) bacteriotoxin, lipopolysaccharide (LPS), into gravid females at embryonic day 10.5 led to the birth of…”
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A Clonal Line of Mesencephalic Progenitor Cells Converted to Dopamine Neurons by Hematopoietic Cytokines: A Source of Cells for Transplantation in Parkinson's Disease by Carvey, P.M., Ling, Z.D., Sortwell, C.E., Pitzer, M.R., McGuire, S.O., Storch, A., Collier, T.J.

“…Neural progenitor cells potentially provide a limitless, on-demand source of cells for grafting into patients with Parkinson's disease (PD) if the signals…”
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Intravenous levodopa in hallucinating Parkinson's disease patients : High-dose challenge does not precipitate hallucinations by GOETZ, C. G, PAPPERT, E. J, BLASUCCI, L. M, STEBBINS, G. T, LING, Z. D, NORA, M. V, CARVEY, P. M

“…In five nondemented Parkinson's disease patients with daily visual hallucinations, we tested whether high-dose IV levodopa (LD) infusions precipitated…”
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Intra-parenchymal injection of tumor necrosis factor-alpha and interleukin 1-beta produces dopamine neuron loss in the rat by Carvey, P M, Chen, E-Y, Lipton, J W, Tong, C W, Chang, Q A, Ling, Z D

“…Inflammatory processes are thought to underlie the dopamine (DA) neuron loss seen in Parkinson's disease (PD). However, it is not known if the inflammation…”
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Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons by DODEL, R. C, DU, Y, BALES, K. R, LING, Z.-D, CARVEY, P. M, PAUL, S. M

“…Multiple aspartate-specific cysteine proteases have been identified and specific members of this family have been implicated in the apoptotic death of many…”
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Neuroprotective effects of D3 dopamine receptor agonists by Carvey, P.M., McGuire, S.O., Ling, Z.D.

“…The effects of D 3 receptor activation are unresolved at this time, but may have practical implications in the treatment of Parkinson's disease (PD). As a…”
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Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole by CARVEY, P. M, PIERI, S, LING, Z. D

“…The direct-acting dopamine (DA) agonist pramipexole (2 amino-4,5,6,7-tetrahydro-6-propyl-amino-benzthiazole-dihydrochlori de) was evaluated for its ability to…”
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Pramipexole attenuates the dopaminergic cell loss induced by intraventricular 6-hydroxydopamine by VU, T. Q, LING, Z. D, MA, S. Y, ROBIE, H. C, TONG, C. W, CHEN, E. Y, LIPTON, J. W, CARVEY, P. M

“…The D3 preferring dopamine agonist pramipexole has been shown to attenuate the cell loss induced by levodopa in vitro. Pramipexole was herein evaluated in the…”
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Alpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients : Dose-response study and correlations with plasma levels by PAPPERT, E. J, TANGNEY, C. C, GOETZ, C. G, LING, Z. D, LIPTON, J. W, STEBBINS, G. T, CARVEY, P. M

“…To determine if ventricular cerebrospinal fluid (vCSF) alpha-tocopherol levels in Parkinson's disease (PD) patients can be increased by oral alpha-tocopherol…”
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Liquid levodopa/carbidopa produces significant improvement in motor function without dyskinesia exacerbation by Pappert, E J, Goetz, C G, Niederman, F, Ling, Z D, Stebbins, G T, Carvey, P M

“…We performed the first double-blind, crossover comparison between levodopa/carbidopa (LD/CD) in optimized liquid versus tablet doses to measure plasma LD…”
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Animal model of posthypoxic myoclonus : Effects of serotonergic antagonists by PAPPERT, E. J, GOETZ, C. G, VU, T. Q, LING, Z. D, LEURGANS, S, RAMAN, R, CARVEY, P. M

“…To study specific serotonin (5-hydroxytryptamine [5-HT]) receptor subtype antagonists in an animal model of posthypoxic myoclonus. Although serotonergic system…”
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Tumor Necrosis Factor α Is Toxic to Embryonic Mesencephalic Dopamine Neurons by McGuire, Susan O, Ling, Zao Dung, Lipton, Jack W, Sortwell, Caryl E, Collier, Timothy J, Carvey, Paul M

“…Levels of the proinflammatory cytokine tumor necrosis factor α (TNFα) are increased in postmortem brain and cerebral spinal fluid from patients with…”
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Differentiation of Mesencephalic Progenitor Cells into Dopaminergic Neurons by Cytokines by Ling, Zao Dung, Potter, Elizabeth D., Lipton, Jack W., Carvey, Paul M.

“…Rat progenitor cells from the germinal region of the fetal mesencephalon were isolated and expanded in media containing the mitogen epidermal growth factor…”
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Loss of Striatal DA Innervation Increases Striatal Trophic Activity Directed at DA Neurons in Culture by Carvey, P.M., Lin, D.H., Faselis, C.J., Notermann, J.K., Ling, Z.D.

“…Male rats received intraventricular infusions of the dopamine (DA) neurotoxin 6-hydroxydopamine (6-OHDA; 0, 75, 150, and 250 μg) in order to determine if DA…”
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The effects of storage conditions and trophic supplementation on the survival of fetal mesencephalic cells by Thajeb, P, Ling, Z D, Potter, E D, Carvey, P M

“…It is estimated that only 5-10% of dopamine (DA) neurons implanted into the striatum of patients undergoing fetal-nigral transplantation as a treatment for…”
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The stability of carbidopa in solution by Pappert, Eric J., Lipton, Jack W., Goetz, Christopher G., Ling, Zao D., Stebbins, Glenn T., Carvey, Paul M.

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Cytokine-induced conversion of mesencephalic-derived progenitor cells into dopamine neurons by Potter, E D, Ling, Z D, Carvey, P M

“…We have previously shown that a combination of the cytokines interleukin (IL)-1, IL-11, leukemia inhibitory factor (LIF), and glial cell line-derived…”
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Comparison of the neurotoxicity of dihydroxyphenylalanine stereoisomers in cultured dopamine neurons by Ling, Z D, Pieri, S C, Carvey, P M

“…Oxidant stress resulting from excess dopamine (DA) may contribute to the development and progression of Parkinson's disease (PD). Free radicals resulting from…”
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GFAP knockout mice have increased levels of GDNF that protect striatal neurons from metabolic and excitotoxic insults by Hanbury, Rose, Ling, Zao Dung, Wuu, Joanne, Kordower, Jeffrey H.

“…In response to injury and degeneration, astrocytes hypertrophy, extend processes, and increase production of glial fibrillary acidic protein (GFAP), an…”
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