Search Results - "Ling, Chen"
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The expanding regulatory mechanisms and cellular functions of circular RNAs
Published in Nature reviews. Molecular cell biology (01-08-2020)“…Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs) through back-splicing of exons. CircRNAs differ from mRNAs in their…”
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The biogenesis and emerging roles of circular RNAs
Published in Nature reviews. Molecular cell biology (01-04-2016)“…Circular RNAs (circRNAs) are produced from precursor RNA back-splicing. Recent findings reveal the complexity of the biogenesis of circRNAs and their cell…”
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Linking Long Noncoding RNA Localization and Function
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01-09-2016)“…Recent studies have revealed the regulatory potential of many long noncoding RNAs (lncRNAs). Most lncRNAs, like mRNAs, are transcribed by RNA polymerase II and…”
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Cellular functions of long noncoding RNAs
Published in Nature cell biology (01-05-2019)“…A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as…”
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The Biogenesis, Functions, and Challenges of Circular RNAs
Published in Molecular cell (02-08-2018)“…Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing of exons of thousands of genes in eukaryotes. circRNAs are generally…”
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Gene regulation by long non-coding RNAs and its biological functions
Published in Nature reviews. Molecular cell biology (01-02-2021)“…Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs) are widely expressed and have key roles in gene regulation. Recent studies…”
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A review of the recent progress in battery informatics
Published in npj computational materials (18-02-2022)“…Batteries are of paramount importance for the energy storage, consumption, and transportation in the current and future society. Recently machine learning (ML)…”
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A strategy to apply machine learning to small datasets in materials science
Published in npj computational materials (14-05-2018)“…There is growing interest in applying machine learning techniques in the research of materials science. However, although it is recognized that materials…”
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Concordant structural variations from the surface to the base of the upper mantle in the North China Craton and its tectonic implications
Published in Lithos (01-11-2010)“…This study presents an integrated study of the North China Craton (NCC) based on recent high-resolution seismic images combined with observations on surface…”
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Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approaches
Published in PloS one (22-12-2020)“…Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory coronavirus 2 (SARS-COV-2) is a significant threat to global health security…”
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Linking a Neurodevelopmental Disorder with a lncRNA Deletion
Published in The New England journal of medicine (24-10-2024)“…This editorial describes the science behind a study linking a severe neurodevelopmental disorder with deletions in a gene ( CHASERR ) that encodes a long…”
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The Diversity of Long Noncoding RNAs and Their Generation
Published in Trends in genetics (01-08-2017)“…Long noncoding RNAs (lncRNAs) are emerging as potential key regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Several…”
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Circular RNAs: Characterization, cellular roles, and applications
Published in Cell (09-06-2022)“…Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs. Recent technological advances have in part overcome problems with their…”
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An institutionalized policy-making mechanism: China’s return to techno-industrial policy
Published in Research policy (01-12-2016)“…Technology and innovation policy in China shifted dramatically in 2003, returning to "techno-industrial policy" that involves direct government interventions…”
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Regulation of circRNA biogenesis
Published in RNA biology (2015)“…Unlike linear RNAs terminated with 5′ caps and 3′ tails, circular RNAs are characterized by covalently closed loop structures with neither 5′ to 3′ polarity…”
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Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria
Published in Nature cell biology (01-10-2018)“…The long noncoding RNA NEAT1 (nuclear enriched abundant transcript 1) nucleates the formation of paraspeckles, which constitute a type of nuclear body with…”
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Cotton pan-genome retrieves the lost sequences and genes during domestication and selection
Published in Genome Biology (23-04-2021)“…Millennia of directional human selection has reshaped the genomic architecture of cultivated cotton relative to wild counterparts, but we have limited…”
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Jaundice revisited: recent advances in the diagnosis and treatment of inherited cholestatic liver diseases
Published in Journal of biomedical science (26-10-2018)“…Jaundice is a common symptom of inherited or acquired liver diseases or a manifestation of diseases involving red blood cell metabolism. Recent progress has…”
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Eight high-quality genomes reveal pan-genome architecture and ecotype differentiation of Brassica napus
Published in Nature plants (01-01-2020)“…Rapeseed ( Brassica napus ) is the second most important oilseed crop in the world but the genetic diversity underlying its massive phenotypic variations…”
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RNA structure probing uncovers RNA structure-dependent biological functions
Published in Nature chemical biology (01-07-2021)“…RNA molecules fold into complex structures that enable their diverse functions in cells. Recent revolutionary innovations in transcriptome-wide RNA structural…”
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