Search Results - "Linford, J."

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion by Vergari, Elisa, Knudsen, Jakob G., Ramracheya, Reshma, Salehi, Albert, Zhang, Quan, Adam, Julie, Asterholm, Ingrid Wernstedt, Benrick, Anna, Briant, Linford J. B., Chibalina, Margarita V., Gribble, Fiona M., Hamilton, Alexander, Hastoy, Benoit, Reimann, Frank, Rorsman, Nils J. G., Spiliotis, Ioannis I., Tarasov, Andrei, Wu, Yanling, Ashcroft, Frances M., Rorsman, Patrik

“…Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers…”
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A repeating fast radio burst source localized to a nearby spiral galaxy by Marcote, B., Nimmo, K., Hessels, J. W. T., Tendulkar, S. P., Bassa, C. G., Paragi, Z., Keimpema, A., Bhardwaj, M., Karuppusamy, R., Kaspi, V. M., Law, C. J., Michilli, D., Aggarwal, K., Andersen, B., Archibald, A. M., Bandura, K., Bower, G. C., Boyle, P. J., Brar, C., Burke-Spolaor, S., Butler, B. J., Cassanelli, T., Chawla, P., Demorest, P., Dobbs, M., Fonseca, E., Giri, U., Good, D. C., Gourdji, K., Josephy, A., Kirichenko, A. Yu, Kirsten, F., Landecker, T. L., Lang, D., Lazio, T. J. W., Li, D. Z., Lin, H.-H., Linford, J. D., Masui, K., Mena-Parra, J., Naidu, A., Ng, C., Patel, C., Pen, U.-L., Pleunis, Z., Rafiei-Ravandi, M., Rahman, M., Renard, A., Scholz, P., Siegel, S. R., Smith, K. M., Stairs, I. H., Vanderlinde, K., Zwaniga, A. V.

“…Fast radio bursts (FRBs) are brief, bright, extragalactic radio flashes 1 , 2 . Their physical origin remains unknown, but dozens of possible models have been…”
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A Search for Late-time Radio Emission and Fast Radio Bursts from Superluminous Supernovae by Law, C. J., Omand, C. M. B., Kashiyama, K., Murase, K., Bower, G. C., Aggarwal, K., Burke-Spolaor, S., Butler, B. J., Demorest, P., Lazio, T. J. W., Linford, J., Tendulkar, S. P., Rupen, M. P.

“…We present results of a search for late-time radio emission and fast radio bursts (FRBs) from a sample of type-I superluminous supernovae (SLSNe-I). We used…”
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Early Spectral Evolution of Classical Novae: Consistent Evidence for Multiple Distinct Outflows by Aydi, E., Chomiuk, L., Izzo, L., Harvey, E. J., Leahy-McGregor, J., Strader, J., Buckley, D. A. H., Sokolovsky, K. V., Kawash, A., Kochanek, C. S., Linford, J. D., Metzger, B. D., Mukai, K., Orio, M., Shappee, B. J., Shishkovsky, L., Steinberg, E., Swihart, S. J., Sokoloski, J. L., Walter, F. M., Woudt, P. A.

“…The physical mechanism driving mass ejection during a nova eruption is still poorly understood. Possibilities include ejection in a single ballistic event, a…”
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Rapid spectral variability of a giant flare from a magnetar in NGC 253 by Roberts, O. J., Veres, P., Baring, M. G., Briggs, M. S., Kouveliotou, C., Bissaldi, E., Younes, G., Chastain, S. I., DeLaunay, J. J., Huppenkothen, D., Tohuvavohu, A., Bhat, P. N., Göğüş, E., van der Horst, A. J., Kennea, J. A., Kocevski, D., Linford, J. D., Guiriec, S., Hamburg, R., Wilson-Hodge, C. A., Burns, E.

“…Magnetars are neutron stars with extremely strong magnetic fields (10 13 to 10 15 gauss) 1 , 2 , which episodically emit X-ray bursts approximately 100…”
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GC-Globulin/Vitamin D-Binding Protein Is Required for Pancreatic α-Cell Adaptation to Metabolic Stress by Viloria, Katrina, Nasteska, Daniela, Ast, Julia, Hasib, Annie, Cuozzo, Federica, Heising, Silke, Briant, Linford J B, Hewison, Martin, Hodson, David J

“…GC-globulin (GC), or vitamin D-binding protein, is a multifunctional protein involved in the transport of circulating vitamin 25(OH)D and fatty acids, as well…”
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Functional identification of islet cell types by electrophysiological fingerprinting by Briant, Linford J. B., Zhang, Quan, Vergari, Elisa, Kellard, Joely A., Rodriguez, Blanca, Ashcroft, Frances M., Rorsman, Patrik

“…The α-, β- and δ-cells of the pancreatic islet exhibit different electrophysiological features. We used a large dataset of whole-cell patch-clamp recordings…”
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Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state by Dai, Xiao-Qing, Camunas-Soler, Joan, Briant, Linford J B, Dos Santos, Theodore, Spigelman, Aliya F, Walker, Emily M, Arrojo E Drigo, Rafael, Bautista, Austin, Jones, Robert C, Avrahami, Dana, Lyon, James, Nie, Aifang, Smith, Nancy, Zhang, Yongneng, Johnson, Janyne, Manning Fox, Jocelyn E, Michelakis, Evangelos D, Light, Peter E, Kaestner, Klaus H, Kim, Seung K, Rorsman, Patrik, Stein, Roland W, Quake, Stephen R, MacDonald, Patrick E

“…In diabetes, glucagon secretion from pancreatic α cells is dysregulated. The underlying mechanisms, and whether dysfunction occurs uniformly among cells,…”
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Optical and near-infrared data and modelling of nova V5668 Sgr by Takeda, L, Diaz, M, Campbell, R D, Lyke, J E, Lawrence, S S, Linford, J D, Sokolovsky, K V

“…ABSTRACT We present Hubble Space Telescope optical images, Keck-OSIRIS near-infrared (NIR) integral field spectroscopy data cubes and Keck-Near InfraRed…”
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Innervation modulates the functional connectivity between pancreatic endocrine cells by Yang, Yu Hsuan Carol, Briant, Linford J B, Raab, Christopher A, Mullapudi, Sri Teja, Maischein, Hans-Martin, Kawakami, Koichi, Stainier, Didier Y R

“…The importance of pancreatic endocrine cell activity modulation by autonomic innervation has been debated. To investigate this question, we established an in…”
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Gap junction coupling and islet delta-cell function in health and disease by Miranda, Caroline, Begum, Manisha, Vergari, Elisa, Briant, Linford J.B.

“…•Somatostatin released from islet delta-cell inhibits glucagon release. In T1D, counter-regulatory glucagon secretion is impaired.•Delta-cells and beta-cells…”
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Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria by Schriner, Samuel E, Linford, Nancy J, Martin, George M, Treuting, Piper, Ogburn, Charles E, Emond, Mary, Coskun, Pinar E, Ladiges, Warren, Wolf, Norman, Van Remmen, Holly, Wallace, Douglas C, Rabinovitch, Peter S

“…To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human catalase localized to the…”
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Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional quality by Linford, Nancy J, Chan, Tammy P, Pletcher, Scott D

“…Organisms perceive changes in their dietary environment and enact a suite of behavioral and metabolic adaptations that can impact motivational behavior,…”
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CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets by Briant, Linford J.B., Dodd, Michael S., Chibalina, Margarita V., Rorsman, Nils J.G., Johnson, Paul R.V., Carmeliet, Peter, Rorsman, Patrik, Knudsen, Jakob G.

“…Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence,…”
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Gustatory and metabolic perception of nutrient stress in Drosophila by Linford, Nancy J, Ro, Jennifer, Chung, Brian Y, Pletcher, Scott D

“…Sleep loss is an adaptive response to nutrient deprivation that alters behavior to maximize the chances of feeding before imminent death. Organisms must…”
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The Peculiar Multiwavelength Evolution Of V1535 Sco by Linford, J. D., Chomiuk, L., Nelson, T., Finzell, T., Walter, F. M., Sokoloski, J. L., Mukai, K., Mioduszewski, A. J., van der Horst, A. J., Weston, J. H. S., Rupen, M. P.

“…We present multiwavelength observations of the unusual nova V1535 Sco throughout its outburst in 2015. Early radio observations were consistent with…”
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Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo by Salem, Victoria, Silva, Luis Delgadillo, Suba, Kinga, Georgiadou, Eleni, Neda Mousavy Gharavy, S., Akhtar, Nadeem, Martin-Alonso, Aldara, Gaboriau, David C. A., Rothery, Stephen M., Stylianides, Theodoros, Carrat, Gaelle, Pullen, Timothy J., Singh, Sumeet Pal, Hodson, David J., Leclerc, Isabelle, Shapiro, A. M. James, Marchetti, Piero, Briant, Linford J. B., Distaso, Walter, Ninov, Nikolay, Rutter, Guy A.

“…Pancreatic β-cells form highly connected networks within isolated islets. Whether this behaviour pertains to the situation in vivo, after innervation and…”
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Constraints on the sub-pc environment of the nearby Type Iax SN 2014dt from deep X-ray and radio observations by Stauffer, C M, Margutti, R, Linford, J D, Chomiuk, L, Coppejans, D L, Demarchi, L, Jacobson-Galán, W, Bright, J, Foley, R J, Horesh, A, Baldeschi, A

“…ABSTRACT We present X-ray and radio observations of what may be the closest Type Iax supernova (SN) to date, SN 2014dt (d = 12.3–19.3 Mpc), and provide tight…”
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Revisiting the classics: on the evolutionary origin of the ‘Fe ii’ and ‘He/N’ spectral classes of novae by Aydi, E, Chomiuk, L, Strader, J, Sokolovsky, K V, Williams, R E, Buckley, D A H, Ederoclite, A, Izzo, L, Kyer, R, Linford, J D, Kniazev, A, Metzger, B D, Mikołajewska, J, Molaro, P, Molina, I, Mukai, K, Munari, U, Orio, M, Panurach, T, Shappee, B J, Shen, K J, Sokoloski, J L, Urquhart, R, Walter, F M

“…ABSTRACT The optical spectra of novae are characterized by emission lines from the hydrogen Balmer series and either Fe ii or He/N, leading to their…”
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The multiwavelength view of shocks in the fastest nova V1674 Her by Sokolovsky, K V, Johnson, T J, Buson, S, Jean, P, Cheung, C C, Mukai, K, Chomiuk, L, Aydi, E, Molina, B, Kawash, A, Linford, J D, Mioduszewski, A J, Rupen, M P, Sokoloski, J L, Williams, M N, Steinberg, E, Vurm, I, Metzger, B D, Page, K L, Orio, M, Quimby, R M, Shafter, A W, Corbett, H, Bolzoni, S, DeYoung, J, Menzies, K, Romanov, F D, Richmond, M, Ulowetz, J, Vanmunster, T, Williamson, G, Lane, D J, Bartnik, M, Bellaver, M, Bruinsma, E, Dugan, E, Fedewa, J, Gerhard, C, Painter, S, Peterson, D-M, Rodriguez, J E, Smith, C, Sullivan, H, Watson, S

“…ABSTRACT Classical novae are shock-powered multiwavelength transients triggered by a thermonuclear runaway on an accreting white dwarf. V1674 Her is the…”
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