Role of ADP-Ribosyl Cyclase in the Pathogenesis of Neurological Disorders after Coronary Artery Bypass Surgery and Experimental Ischemia

Role of ADP-Ribosyl Cyclase in the Pathogenesis of Neurological Disorders after Coronary Artery Bypass Surgery and Experimental Ischemia

The pathogenesis of neuronal dysfunction was evaluated from the viewpoint of cellular disturbances in NAD⁺ metabolism and changes in activity of NAD⁺-utilizing enzymes (e.g., ADP-ribosyl cyclase/CD38). S-100B concentration and CD38 expression on peripheral blood lymphocytes were altered in patients...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 147; no. 5; pp. 570 - 572
Main Authors: Moroz, V. V, Salmina, A. B, Fursov, A. A, Mikhutkina, S. V, Linev, K. Y, Mantorova, N. S, Shakhmaeva, S. V
Format: Journal Article
Language:English
Published: Boston Boston : Springer US 01-05-2009
Springer US
Springer Nature B.V
Subjects:
ADP-ribosyl Cyclase - metabolism
ADP-ribosyl Cyclase - physiology
ADP-ribosyl Cyclase 1 - metabolism
ADP-ribosyl cyclase/CD38
Animals
Biomedical and Life Sciences
Biomedicine
Brain - cytology
Cell Biology
Coronary Artery Bypass
General Pathology and Pathological Physiology
Humans
Immunoassay
Internal Medicine
Ischemia - metabolism
Ischemia - physiopathology
Laboratory Medicine
Male
NAD
NAD - metabolism
Nerve Growth Factors - metabolism
Neurological disorders
neuronal dysfunction
Neurons - enzymology
Neurons - pathology
Pathology
Postoperative Period
Rats
S100 Calcium Binding Protein beta Subunit
S100 Proteins - metabolism
ADP-ribosyl cyclase/CD38
NAD
neuronal dysfunction
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Summary:The pathogenesis of neuronal dysfunction was evaluated from the viewpoint of cellular disturbances in NAD⁺ metabolism and changes in activity of NAD⁺-utilizing enzymes (e.g., ADP-ribosyl cyclase/CD38). S-100B concentration and CD38 expression on peripheral blood lymphocytes were altered in patients after surgery for coronary heart disease with extracorporeal circulation. These changes in patients during the early postoperative period correlated with variations in CD38 expression on neuronal cells from postischemic rats with cognitive dysfunction.
Bibliography:http://dx.doi.org/10.1007/s10517-009-0580-5
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0580-5