Search Results - "Linette, G."

Checkpoint Inhibitors in Kidney Transplant Recipients and the Potential Risk of Rejection by Alhamad, T., Venkatachalam, K., Linette, G. P., Brennan, D. C.

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Extensive tumoral melanosis associated with ipilimumab‐treated melanoma by Staser, K., Chen, D., Solus, J., Rosman, I.S., Schaffer, A., Cornelius, L., Linette, G.P., Fields, R.C.

“…Summary Tumoral melanosis describes a pigmented lesion clinically similar to melanoma but on histology reveals dense aggregates of melanin‐laden, benign…”
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Avelumab in patients with previously treated metastatic Merkel cell carcinoma (JAVELIN Merkel 200): updated overall survival data after >5 years of follow-up by D'Angelo, S.P., Bhatia, S., Brohl, A.S., Hamid, O., Mehnert, J.M., Terheyden, P., Shih, K.C., Brownell, I., Lebbé, C., Lewis, K.D., Linette, G.P., Milella, M., Xiong, H., Guezel, G., Nghiem, P.T.

“…Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer that has a poor prognosis in patients with advanced disease. Avelumab [anti-programmed…”
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Cross Talk between Cell Death and Cell Cycle Progression: BCL-2 Regulates NFAT-Mediated Activation by Linette, Gerald P., Li, Ying, Roth, Kevin, Korsmeyer, Stanley J.

“…BCL-2-deficient T cells demonstrate accelerated cell cycle progression and increased apoptosis following activation. Increasing the levels of BCL-2 retarded…”
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Targeted therapy in breast cancer: the HER-2/neu gene and protein by Ross, Jeffrey S, Fletcher, Jonathan A, Bloom, Kenneth J, Linette, Gerald P, Stec, James, Symmans, W Fraser, Pusztai, Lajos, Hortobagyi, Gabriel N

“…The HER-2/neu oncogene, a member of the epidermal growth factor receptor or erb gene family, encodes a transmembrane tyrosine kinase receptor that has been…”
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Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77) by Lee, Stephen L., Wesselschmidt, Robin L., Linette, Gerald P., Kanagawa, Osami, Russell, John H., Milbrandt, Jeffrey

“…T cell hybridomas require the immediate-early gene NGFI-B (nur77) for T cell receptor (TCR)-mediated apoptosis, a model for negative selection of self-reactive…”
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Bcl-XL and Bcl-2 repress a common pathway of cell death by Chao, D T, Linette, G P, Boise, L H, White, L S, Thompson, C B, Korsmeyer, S J

“…The effect of Bcl-xL upon the developmental death of T cells was assessed by generating transgenic mice that expressed Bcl-xL within all thymocyte subsets…”
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Antimelanoma Activity of CTL Generated from Peripheral Blood Mononuclear Cells After Stimulation with Autologous Dendritic Cells Pulsed with Melanoma gp100 Peptide G209-2M Is Correlated to TCR Avidity by Yang, Sixun, Linette, Gerald P, Longerich, Simonne, Haluska, Frank G

“…Anchor residue-modified peptides derived from tumor-associated Ag have demonstrated success in engendering immune responses in clinical studies. However, tumor…”
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9317 Ipilimumab re-induction after progression in patients with advanced melanoma enrolled in Phase II clinical trials by Harmankaya, K, Minor, D, Linette, G, Ridolfi, R, Corsa, j, Ibrahim, R, Lebbé, C

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Targeted therapies for cancer 2004 by ROSS, Jeffrey S, SCHENKEIN, David P, HORTOBAGYI, Gabriel N, PIETRUSKO, Robert, ROLFE, Mark, LINETTE, Gerald P, STEC, James, STAGLIANO, Nancy E, GINSBURG, Geoffrey S, SYMMANS, W. Fraser, PUSZTAI, Lajos

“…The regulatory agency approvals in the United States and Europe of imatinib mesylate (Gleevec) for patients with bcr/abl-positive chronic myelogenous leukemia,…”
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Induction of anti‐HIV neutralizing antibodies by synthetic peptides by Chanh, T.C., Dreesman, G.R., Kanda, P., Linette, G.P., Sparrow, J.T., Ho, D.D., Kennedy, R.C.

“…Two synthetic peptides containing amino acid sequences analogous to the envelope glycoprotein of human T‐lymphotropic virus (HTLV) type III (HTLV‐III) and…”
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Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family by Korsmeyer, Stanley J., Yin, Xiao-Ming, Oltvai, Zoltán N., Veis-Novack, Deborah J., Linette, Gerald P.

“…The maintenance of homeostasis in normal tissues reflects a balance between cell proliferation and cell death. Bcl-2 inaugurated a new category of oncogenes,…”
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7004 ORAL Phase II randomized, placebo controlled study of sorafenib in combination with dacarbazine in subjects with unresectable Stage III or Stage IV melanoma by McDermott, D, Sosman, J.A, Hodi, F.S, Gonzalez, R, Linette, G, Richards, J, Jakub, J.K, Beeram, M, Patel, K, Hersch, E

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HIV-1--Infected T Cells Show a Selective Signaling Defect after Perturbation of CD3/Antigen Receptor by Linette, Gerald P., Hartzman, Robert J., Ledbetter, Jeffrey A., June, Carl H.

“…The binding of antigen or monoclonal antibody to the T cell receptor for antigen or the closely associated CD3 complex causes increases in the concentration of…”
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Discussion of the requirements, challenges and processing adaptions involved in an academic technology transfer of neo-antigen peptide pulsed dendritic cells by L. Brennan, A., Guilliams, J., Fox, E., Carreno, B., Linette, G., Levine, B.L., Plesaw, G., Siegel, D., Mackey, S., Fesnak, A.

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Bcl-2 gene family and the regulation of programmed cell death by Yin, X M, Oltvai, Z N, Veis-Novack, D J, Linette, G P, Korsmeyer, S J

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In Vitro Priming with Adenovirus/gp100 Antigen-Transduced Dendritic Cells Reveals the Epitope Specificity of HLA-A0201-Restricted CD8+ T Cells in Patients with Melanoma by Linette, Gerald P, Shankara, Srinivas, Longerich, Simonne, Yang, Sixun, Doll, Rhonda, Nicolette, Charles, Preffer, Frederic I, Roberts, Bruce L, Haluska, Frank G

“…Replication-deficient recombinant adenovirus (Ad) encoding human gp100 or MART-1 melanoma Ag was used to transduce human dendritic cells (DC) ex vivo as a…”
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Differentiation and cell death: lessons from the immune system by Linette, G P, Korsmeyer, S J

“…The immune system provides a unique vantage point from which to view the interrelationship between differentiation and cell death, as apoptosis is a prominent…”
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Molecular diagnostics in melanoma by Carlson, J. Andrew, Ross, Jeffery S., Slominski, Andrzej, Linette, Gerald, Mysliborski, Judith, Hill, Jerome, Mihm, Martin

“…Molecular pathology is rapidly evolving, featuring continuous technologic improvements that offer novel clinical opportunities for the recognition of disease…”
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Peripheral T-Cell Lymphoma in lckpr-bcl-2 Transgenic Mice by Linette, Gerald P., Hess, Jay L., Sentman, Charles L., Korsmeyer, Stanley J.

“…t(14;18) is the most common translocation in human lymphoid malignancy and results in bcl-2 overexpression. bcl-2 blocks apoptosis and constitutes the initial…”
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