Search Results - "Lines, K E"

S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer by Srivastava, K., Lines, K. E., Jach, D., Crnogorac-Jurcevic, T.

“…We have previously shown that expression of S100PBP, an S100P binding partner, gradually decreases during progression of pancreatic ductal adenocarcinomas…”
Get full text

A MEN1 pancreatic neuroendocrine tumour mouse model under temporal control by Lines, K E, Vas Nunes, R P, Frost, M, Yates, C J, Stevenson, M, Thakker, R V

“…Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by occurrence of parathyroid tumours and neuroendocrine tumours…”
Get full text

A short-term economic assessment of incentivised selective gears by O’Neill, F.G., Lines, E.K., Kynoch, R.J., Fryer, R.J., Maguire, S.

“…An economic analysis of the impact of introducing more selective fishing gears and how their uptake is incentivised is carried out. The study focusses on some…”
Get full text

Animal models of pituitary neoplasia by Lines, K.E., Stevenson, M., Thakker, R.V.

“…Pituitary neoplasias can occur as part of a complex inherited disorder, or more commonly as sporadic (non-familial) disease. Studies of the molecular and…”
Get full text

Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome by Walls, G V, Stevenson, M, Lines, K E, Newey, P J, Reed, A A C, Bowl, M R, Jeyabalan, J, Harding, B, Bradley, K J, Manek, S, Chen, J, Wang, P, Williams, B O, Teh, B T, Thakker, R V

“…The hyperparathyroidism-jaw tumour (HPT-JT) syndrome is an autosomal dominant disorder characterized by occurrence of parathyroid tumours, often atypical…”
Get full text

miR-15a/miR-16-1 expression inversely correlates with cyclin D1 levels in Men1 pituitary NETs by Lines, K E, Newey, P J, Yates, C J, Stevenson, M, Dyar, R, Walls, G V, Bowl, M R, Thakker, R V

“…Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by the combined occurrence of parathyroid, pituitary and pancreatic…”
Get full text

Effects of epigenetic pathway inhibitors on corticotroph tumour AtT20 cells by Lines, K E, Filippakopoulos, P, Stevenson, M, Müller, S, Lockstone, H E, Wright, B, Knapp, S, Buck, D, Bountra, C, Thakker, R V

“…Medical treatments for corticotrophinomas are limited, and we therefore investigated the effects of epigenetic modulators, a new class of anti-tumour drugs, on…”
Get full text

HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: MEN1-related pancreatic NETs: identification of unmet clinical needs and future directives by Pieterman, C R C, Sadowski, S M, Maxwell, J E, Katz, M H G, Lines, K E, Heaphy, C M, Tirosh, A, Blau, J E, Perrier, N D, Lewis, M A, Metzcar, J P, Halperin, D M, Thakker, R V, Valk, G D

“…The PanNET Working Group of the 16th International Multiple Endocrine Neoplasia Workshop (MEN2019) convened in Houston, TX, USA, 27–29 March 2019 to discuss…”
Get full text

Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors by Lines, K E, Stevenson, M, Filippakopoulos, P, Müller, S, Lockstone, H E, Wright, B, Grozinsky-Glasberg, S, Grossman, A B, Knapp, S, Buck, D, Bountra, C, Thakker, R V

“…Cancer is associated with alterations in epigenetic mechanisms such as histone modifications and methylation of DNA, and inhibitors targeting epigenetic…”
Get full text

Hypoxia stimulates angiogenesis and a metabolic switch in human parathyroid adenoma cells by Lines, K E, Stevenson, M, Mihai, R, Grigorieva, I V, Shariq, O A, Gaynor, K U, Jeyabalan, J, Javid, M, Thakker, R V

“…Hypoxia, a primary stimulus for angiogenesis, is important for tumour proliferation and survival. The effects of hypoxia on parathyroid tumour cells, which may…”
Get full text