Search Results - "Lindtner, Beate"

Constitutive activation of akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation by BRANDTS, Christian H, SARGIN, Bülent, BERDEL, Wolfgang E, SERVE, Hubert, RODE, Miriam, BIERMANN, Christoph, LINDTNER, Beate, SCHWÄBLE, Joachim, BUERGER, Horst, MÜLLER-TIDOW, Carsten, CHOUDHARY, Chunaram, MCMAHON, Martin

“…Up to 30% of patients with acute myeloid leukemia (AML) harbor internal tandem duplications (ITD) within the FLT3 gene, encoding a receptor tyrosine kinase…”
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In Vivo RNAi Screening Identifies HDAC4 As a Mediator Of Chemoresistance In Acute Myeloid Leukemia by Lettermann, Stephanie, Agelopoulos, Konstantin, Rohde, Christian, Lindtner, Beate, Marek, Linda, Hempel, Georg, Stelljes, Matthias, Berdel, Wolfgang E., Kurz, Thomas, Müller-Tidow, Carsten

“…The majority of AML patients still relapse, despite intensive chemotherapy. A subset of more chemoresistant leukemia cells might be responsible for this…”
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Activation of AKT1 in Hematopoietic Stem Cells Causes a Myeloproliferative Disease in a Tet-Inducible Mouse Model by Brandts, Christian, Rode, Miriam, Lindtner, Beate, Koehler, Gabriele, Koschmieder, Steffen, Mueller-Tidow, Carsten, Berdel, Wolfgang E., Serve, Hubert

“…Activating mutations in Flt3, N- and K-Ras have been reported in all AML subtypes and represent common molecular defects in de novo AML. We have previously…”
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Constitutive Activation of Akt and mTOR by Flt3 Internal Tandem Duplications Mediates Myeloid Leukemogenesis and Can Be Inhibited by Rapamycin by Brandts, Christian H., Sargin, Bulent, Rode, Miriam, Biermann, Christoph, Lindtner, Beate, Schwable, Joachim, Buerger, Horst, Muller-Tidow, Carsten, Choudhary, Chunaram, McMahon, Martin, Berdel, Wolfgang E., Serve, Hubert L.

“…Up to 30% of patients with acute myeloid leukemia (AML) harbor internal tandem duplications (ITD) within the FLT3 gene, a tyrosine kinase receptor. The…”
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