Search Results - "Lindstrom, Aaron"

Porphyrin-Based Nanomedicines for Cancer Treatment by Xue, Xiangdong, Lindstrom, Aaron, Li, Yuanpei

“…As unique molecules with both therapeutic and diagnostic properties, porphyrin derivatives have been extensively employed for cancer treatment. Porphyrins not…”
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Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy by Ma, Zhao, Li, Jin, Lin, Kai, Ramachandran, Mythili, Zhang, Dalin, Showalter, Megan, De Souza, Cristabelle, Lindstrom, Aaron, Solano, Lucas N., Jia, Bei, Urayama, Shiro, Duan, Yuyou, Fiehn, Oliver, Lin, Tzu-yin, Li, Minyong, Li, Yuanpei

“…Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here we propose a…”
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Large-Scale Screening and Identification of Novel Ebola Virus and Marburg Virus Entry Inhibitors by Anantpadma, Manu, Kouznetsova, Jennifer, Wang, Hang, Huang, Ruili, Kolokoltsov, Andrey, Guha, Rajarshi, Lindstrom, Aaron R, Shtanko, Olena, Simeonov, Anton, Maloney, David J, Maury, Wendy, LaCount, Douglas J, Jadhav, Ajit, Davey, Robert A

“…Filoviruses are highly infectious, and no FDA-approved drug therapy for filovirus infection is available. Most work to find a treatment has involved only a few…”
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SEMA3C Supports Pancreatic Cancer Progression by Regulating the Autophagy Process and Tumor Immune Microenvironment by Zhang, Dalin, Lindstrom, Aaron, Kim, Edward J, Hwang, Chang-Il, Hall, Madison Lee, Lin, Tzu-Yin, Li, Yuanpei

“…To date, driver genes for pancreatic cancer treatment are difficult to pursue therapeutically. Targeting mutated KRAS, the most renowned driver gene in…”
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Evaluation of Phenol-Substituted Diphyllin Derivatives as Selective Antagonists for Ebola Virus Entry by Plescia, Caroline B., Lindstrom, Aaron R., Quintero, Maritza V., Keiser, Patrick, Anantpadma, Manu, Davey, Robert, Stahelin, Robert V., Davisson, V. Jo

“…Ebola virus (EBOV) is an aggressive filoviral pathogen that can induce severe hemorrhagic fever in humans with up to 90% fatality rate. To date, there are no…”
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Author Correction: Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy by Ma, Zhao, Li, Jin, Lin, Kai, Ramachandran, Mythili, Zhang, Dalin, Showalter, Megan, De Souza, Cristabelle, Lindstrom, Aaron, Solano, Lucas N., Jia, Bei, Urayama, Shiro, Duan, Yuyou, Fiehn, Oliver, Lin, Tzu-yin, Li, Minyong, Li, Yuanpei

“…A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22419-2…”
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Rotatable Aggregation‐Induced‐Emission/Aggregation‐Caused‐Quenching Ratio Strategy for Real‐Time Tracking Nanoparticle Dynamics by Wu, Hao, Zhang, Lu, Yang, Jinfan, Bo, Ruonan, Du, Hongxu, Lin, Kai, Zhang, Dalin, Ramachandran, Mythili, Shen, Yingbin, Xu, Yangxi, Xue, Xiangdong, Ma, Zhao, Lindstrom, Aaron Raymond, Carney, Randy, Lin, Tzu‐Yin, Li, Yuanpei

“…Real‐time tracking of the dynamics change of self‐assembled nanostructures in physiological environments is crucial to improving their delivery efficiency and…”
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Peptide-based materials for cancer immunotherapy by Zhang, Lu, Huang, Yanyu, Lindstrom, Aaron Raymond, Lin, Tzu-Yin, Lam, Kit S, Li, Yuanpei

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Nanomaterials as potential transporters of HDAC inhibitors by De Souza, Cristabelle, Ma, Zhao, Lindstrom, Aaron Raymond, Chatterji, Biswa Prasun

“…Nanomedicine that combines technology with medical diagnostics and therapeutics is now advancing to greater heights for its significant potential in drug…”
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Peptide-based materials for cancer immunotherapy by Zhang, Lu, Huang, Yanyu, Lindstrom, Aaron Raymond, Lin, Tzu-Yin, Lam, Kit S, Li, Yuanpei

“…Peptide-based materials hold great promise as immunotherapeutic agents for the treatment of many malignant cancers. Extensive studies have focused on the…”
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Recent advances on small‐molecule nanomedicines for cancer treatment by Xue, Xiangdong, Lindstrom, Aaron, Qu, Haijing, Li, Yuanpei

“…Nanomedicines have made important contributions in the development of cancer therapies due to their tumor selectivity, multifunctionality, and synergistic…”
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Single Small Molecule‐Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo by Lin, Kai, Ma, Zhao, Li, Jin, Tang, Menghuan, Lindstrom, Aaron, Ramachandran, Mythili, Zhu, Shaoming, Lin, Tzu‐yin, Zhang, Lanwei, Li, Yuanpei

“…Photodynamic therapy (PDT) has emerged as an attractive alternative in cancer therapy, but its therapeutic effects are limited by the nonselective subcellular…”
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Iron-crosslinked Rososome with robust stability and high drug loading for synergistic cancer therapy by Xue, Xiangdong, Ricci, Marina, Qu, Haijing, Lindstrom, Aaron, Zhang, Dalin, Wu, Hao, Lin, Tzu-Yin, Li, Yuanpei

“…Development of liposomal nanomedicine with robust stability, high drug loading and synergistic efficacy is a promising strategy for effective cancer therapy…”
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Deep tumor-penetrating nano-delivery strategy to improve diagnosis and therapy in patient-derived xenograft (PDX) oral cancer model and patient tissue by Li, Longmeng, Lindstrom, Aaron R., Birkeland, Andrew C., Tang, Menghuan, Lin, Tzu-Yin, Zhou, Yikai, Xiang, Bai, Xue, Xiangdong, Li, Yuanpei

“…Nanoprodrugs that are directly assembled by prodrugs attract considerable attention with high anticancer potentials. However, their stability and efficiency of…”
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A nephrotoxicity-free, iron-based contrast agent for magnetic resonance imaging of tumors by Xue, Xiangdong, Bo, Ruonan, Qu, Haijing, Jia, Bei, Xiao, Wenwu, Yuan, Ye, Vapniarsky, Natalia, Lindstrom, Aaron, Wu, Hao, Zhang, Dalin, Li, Longmeng, Ricci, Marina, Ma, Zhao, Zhu, Zheng, Lin, Tzu-yin, Louie, Angelique Y., Li, Yuanpei

“…Gadolinium-based contrast agents (GBCAs) are the most widely used T1 contrast agents for magnetic resonance imaging (MRI) and have achieved remarkable success…”
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Phenotypic Prioritization of Diphyllin Derivatives That Block Filoviral Cell Entry by Vacuolar (H+)‐ATPase Inhibition by Lindstrom, Aaron, Anantpadma, Manu, Baker, Logan, Raghavendra, N. M., Davey, Robert, Davisson, Vincent Jo

“…Many viruses use endosomal pathways to gain entry into cells and propagate infection. Sensing of endosomal acidification is a trigger for the release of many…”
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Phenotypic Prioritization of Diphyllin Derivatives that Block Filo-viral Cell Entry by Vacuolar (H+)-ATPase Inhibition by Lindstrom, Aaron, Anantpadma, Manu, Baker, Logan, Raghavendra, N.M., Davey, Robert, Davisson, Vincent Jo

“…Many viruses utilize endosomal pathways to gain entry to cells and propagate infection. Sensing of endosomal acidification is a trigger for release of many…”
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Synthesis and Identification of Novel Arylnaphthalene V-Atpase Inhibitors as Selective Anti-Filoviral Agents by Lindstrom, Aaron

“…Ebolavirus, a genus of filoviruses, are responsible for outbreaks that cause up to 90% fatality, including the recent outbreak in West Africa that has resulted…”
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Discovery of C‑Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV‑2 by Mesaros, Eugen F., Dugan, Benjamin J., Gao, Min, Sheraz, Muhammad, McGovern-Gooch, Kayleigh, Xu, Fran, Fan, Kristi Yi, Nguyen, Duyan, Kultgen, Steven G., Lindstrom, Aaron, Stever, Kim, Tercero, Breanna, Binder, Randall J., Liu, Fei, Micolochick Steuer, Holly M., Mani, Nagraj, Harasym, Troy O., Thi, Emily P., Cuconati, Andrea, Dorsey, Bruce D., Cole, Andrew G., Lam, Angela M., Sofia, Michael J.

“…The recent COVID-19 pandemic underscored the limitations of currently available direct-acting antiviral treatments against acute respiratory RNA-viral…”
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Scalar Field Collapse: Leveraging Numerical Relativity to Simulate Black Hole Formation and Localize Apparent Horizons by Lindstrom, Kyle Aaron Panattoni

“…This thesis explores models of collapsing matter by leveraging the dynamics of scalar fields. Understanding the evolution of these fields in curved spacetime,…”
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