Search Results - "Lindström, Nils O."

Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney by Ransick, Andrew, Lindström, Nils O., Liu, Jing, Zhu, Qin, Guo, Jin-Jin, Alvarado, Gregory F., Kim, Albert D., Black, Hannah G., Kim, Junhyong, McMahon, Andrew P.

“…Chronic kidney disease affects 10% of the population with notable differences in ethnic and sex-related susceptibility to kidney injury and disease. Kidney…”
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Conserved and Divergent Features of Human and Mouse Kidney Organogenesis by Lindström, Nils O, McMahon, Jill A, Guo, Jinjin, Tran, Tracy, Guo, Qiuyu, Rutledge, Elisabeth, Parvez, Riana K, Saribekyan, Gohar, Schuler, Robert E, Liao, Christopher, Kim, Albert D, Abdelhalim, Ahmed, Ruffins, Seth W, Thornton, Matthew E, Baskin, Laurence, Grubbs, Brendan, Kesselman, Carl, McMahon, Andrew P

“…Human kidney function is underpinned by approximately 1,000,000 nephrons, although the number varies substantially, and low nephron number is linked to…”
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Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney by Lindström, Nils O, Guo, Jinjin, Kim, Albert D, Tran, Tracy, Guo, Qiuyu, De Sena Brandine, Guilherme, Ransick, Andrew, Parvez, Riana K, Thornton, Matthew E, Baskin, Laurence, Grubbs, Brendan, McMahon, Jill A, Smith, Andrew D, McMahon, Andrew P

“…Cellular interactions among nephron, interstitial, and collecting duct progenitors drive mammalian kidney development. In mice, Six2 nephron progenitor cells…”
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Building a kidney tree: Functional collecting duct from human pluripotent stem cells by Li, Zhongwei, Lindström, Nils O

“…Human developmental studies and regenerative therapies need in vitro systems that generate cell types recapitulating mature cell physiologies. In a recent…”
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Progressive Recruitment of Mesenchymal Progenitors Reveals a Time-Dependent Process of Cell Fate Acquisition in Mouse and Human Nephrogenesis by Lindström, Nils O., De Sena Brandine, Guilherme, Tran, Tracy, Ransick, Andrew, Suh, Gio, Guo, Jinjin, Kim, Albert D., Parvez, Riana K., Ruffins, Seth W., Rutledge, Elisabeth A., Thornton, Matthew E., Grubbs, Brendan, McMahon, Jill A., Smith, Andrew D., McMahon, Andrew P.

“…Mammalian nephrons arise from a limited nephron progenitor pool through a reiterative inductive process extending over days (mouse) or weeks (human) of kidney…”
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In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes by Tran, Tracy, Lindström, Nils O., Ransick, Andrew, De Sena Brandine, Guilherme, Guo, Qiuyu, Kim, Albert D., Der, Balint, Peti-Peterdi, Janos, Smith, Andrew D., Thornton, Matthew, Grubbs, Brendan, McMahon, Jill A., McMahon, Andrew P.

“…The renal corpuscle of the kidney comprises a glomerular vasculature embraced by podocytes and supported by mesangial myofibroblasts, which ensure plasma…”
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Spatial transcriptional mapping of the human nephrogenic program by Lindström, Nils O., Sealfon, Rachel, Chen, Xi, Parvez, Riana K., Ransick, Andrew, De Sena Brandine, Guilherme, Guo, Jinjin, Hill, Bill, Tran, Tracy, Kim, Albert D., Zhou, Jian, Tadych, Alicja, Watters, Aaron, Wong, Aaron, Lovero, Elizabeth, Grubbs, Brendan H., Thornton, Matthew E., McMahon, Jill A., Smith, Andrew D., Ruffins, Seth W., Armit, Chris, Troyanskaya, Olga G., McMahon, Andrew P.

“…Congenital abnormalities of the kidney and urinary tract are among the most common birth defects, affecting 3% of newborns. The human kidney forms around a…”
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Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system by Rutledge, Elisabeth A., Lindström, Nils O., Michos, Odysse, McMahon, Andrew P.

“…The ureteric epithelial progenitor (UEP) population within the embryonic kidney generates the arborized epithelial network of the kidney’s collecting system…”
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Single-Cell RNA Sequencing of the Adult Mouse Kidney: From Molecular Cataloging of Cell Types to Disease-Associated Predictions by Lindström, Nils O., De Sena Brandine, Guilherme, Ransick, Andrew, McMahon, Andrew P.

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Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease by Huang, Biao, Zeng, Zipeng, Kim, Sunghyun, Fausto, Connor C, Koppitch, Kari, Li, Hui, Li, Zexu, Chen, Xi, Guo, Jinjin, Zhang, Chennan C, Ma, Tianyi, Medina, Pedro, Schreiber, Megan E, Xia, Mateo W, Vonk, Ariel C, Xiang, Tianyuan, Patel, Tadrushi, Li, Yidan, Parvez, Riana K, Der, Balint, Chen, Jyun Hao, Liu, Zhenqing, Thornton, Matthew E, Grubbs, Brendan H, Diao, Yarui, Dou, Yali, Gnedeva, Ksenia, Ying, Qilong, Pastor-Soler, Nuria M, Fei, Teng, Hallows, Kenneth R, Lindström, Nils O, McMahon, Andrew P, Li, Zhongwei

“…Nephron progenitor cells (NPCs) self-renew and differentiate into nephrons, the functional units of the kidney. Here, manipulation of p38 and YAP activity…”
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Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment by O'Brien, Lori L, Combes, Alexander N, Short, Kieran M, Lindström, Nils O, Whitney, Peter H, Cullen-McEwen, Luise A, Ju, Adler, Abdelhalim, Ahmed, Michos, Odyssé, Bertram, John F, Smyth, Ian M, Little, Melissa H, McMahon, Andrew P

“…A normal endowment of nephrons in the mammalian kidney requires a balance of nephron progenitor self-renewal and differentiation throughout development. Here,…”
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Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron by Lindström, Nils O, Lawrence, Melanie L, Burn, Sally F, Johansson, Jeanette A, Bakker, Elvira R M, Ridgway, Rachel A, Chang, C-Hong, Karolak, Michele J, Oxburgh, Leif, Headon, Denis J, Sansom, Owen J, Smits, Ron, Davies, Jamie A, Hohenstein, Peter

“…The different segments of the nephron and glomerulus in the kidney balance the processes of water homeostasis, solute recovery, blood filtration, and…”
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Nephrons require Rho-kinase for proximal-distal polarity development by Lindström, Nils O., Hohenstein, Peter, Davies, Jamie A.

“…Epithelial tubules must have the right length and pattern for proper function. In the nephron, planar cell polarity controls elongation along the…”
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Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice by Berry, Rachel L, Ozdemir, Derya D, Aronow, Bruce, Lindström, Nils O, Dudnakova, Tatiana, Thornburn, Anna, Perry, Paul, Baldock, Richard, Armit, Chris, Joshi, Anagha, Jeanpierre, Cécile, Shan, Jingdong, Vainio, Seppo, Baily, James, Brownstein, David, Davies, Jamie, Hastie, Nicholas D, Hohenstein, Peter

“…Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically…”
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Dact2 is expressed in the developing ureteric bud/collecting duct system of the kidney and controls morphogenetic behavior of collecting duct cells by Lee, Wen-Chin, Hough, Melinda T, Liu, Weijia, Ekiert, Robert, Lindström, Nils O, Hohenstein, Peter, Davies, Jamie A

“…The overall pattern of the developing kidney is set in large part by the developing ureteric bud/collecting duct system, and dysgenesis of this system accounts…”
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Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning by Lindström, Nils O, Tran, Tracy, Guo, Jinjin, Rutledge, Elisabeth, Parvez, Riana K, Thornton, Matthew E, Grubbs, Brendan, McMahon, Jill A, McMahon, Andrew P

“…The nephron is the functional unit of the kidney, but the mechanism of nephron formation during human development is unclear. We conducted a detailed analysis…”
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A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery by Tran, Tracy, Song, Cheng Jack, Nguyen, Trang, Cheng, Shun-Yang, McMahon, Jill A., Yang, Rui, Guo, Qiuyu, Der, Balint, Lindström, Nils O., Lin, Daniel C.-H., McMahon, Andrew P.

“…Human pluripotent stem-cell-derived organoids are models for human development and disease. We report a modified human kidney organoid system that generates…”
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A comparative study of cellular diversity between the Xenopus pronephric and mouse metanephric nephron by Corkins, Mark E, Achieng, MaryAnne, DeLay, Bridget D, Krneta-Stankic, Vanja, Cain, Margo P, Walker, Brandy L, Chen, Jichao, Lindström, Nils O, Miller, Rachel K

“…The kidney is an essential organ that ensures bodily fluid homeostasis and removes soluble waste products from the organism. Nephrons, the functional units of…”
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The developmental and genetic basis of 'clubfoot' in the peroneal muscular atrophy mutant mouse by Collinson, J Martin, Lindström, Nils O, Neves, Carlos, Wallace, Karen, Meharg, Caroline, Charles, Rebecca H, Ross, Zoe K, Fraser, Amy M, Mbogo, Ivan, Oras, Kadri, Nakamoto, Masaru, Barker, Simon, Duce, Suzanne, Miedzybrodzka, Zosia, Vargesson, Neil

“…Genetic factors underlying the human limb abnormality congenital talipes equinovarus ('clubfoot') remain incompletely understood. The spontaneous autosomal…”
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Correction: A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells by Guo, Qiuyu, Kim, Albert D, Li, Bin, Ransick, Andrew, Bugacov, Helena, Chen, Xi, Lindström, Nils O, Brown, Aaron, Oxburgh, Leif, Ren, Bing, McMahon, Andrew P

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