Cytokines and the Microcirculation in Ischemia and Reperfusion

The intense inflammatory reaction following reperfusion of the infarcted myocardium has been implicated as a factor in extension of injury. However, this inflammatory reaction is also critical to tissue repair. The cellular responses that mediate these functions are orchestrated by sequential induct...

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Bibliographic Details
Published in:	Journal of molecular and cellular cardiology Vol. 30; no. 12; pp. 2567 - 2576
Main Authors:	Frangogiannis, Nikolaos G., Youker, Keith A., Rossen, Roger D., Gwechenberger, Marianne, Lindsey, Merry H., Mendoza, Leonardo H., Michael, Lloyd H., Ballantyne, Christie M., Smith, C.Wayne, Entman, Mark L.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-12-1998
Subjects:	Animals Cardiac tissue repair CD11 Antigens - chemistry CD18 Antigens - chemistry CD5 Antigens - chemistry Cytokines Cytokines - physiology Dogs Female Heart - physiology Inflammation Intercellular Adhesion Molecule-1 - biosynthesis Intercellular Adhesion Molecule-1 - physiology Interleukin-10 - chemistry Interleukin-10 - physiology Leukocytes Macrophage Colony-Stimulating Factor - chemistry Macrophage Colony-Stimulating Factor - physiology Macrophages Male Mast Cells - physiology Microcirculation - physiology Models, Biological Neutrophils - physiology Osteopontin Reperfusion injury Reperfusion Injury - metabolism Sialoglycoproteins - chemistry Sialoglycoproteins - physiology Time Factors Cardiac tissue repair Inflammation Leukocytes Cytokines Reperfusion injury
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Summary:	The intense inflammatory reaction following reperfusion of the infarcted myocardium has been implicated as a factor in extension of injury. However, this inflammatory reaction is also critical to tissue repair. The cellular responses that mediate these functions are orchestrated by sequential induction and/or release of cytokines resulting in a closely regulated cytokine cascade. This paper reviews research on these cytokine cascades, their cellular origin, and factors which control the cellular response to their presence. Factors examined include leukotaxis, phenotypic transition of leukocytes, adhesion molecule induction and the role of cytokines in tissue repair and scar formation.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0022-2828 1095-8584
DOI:	10.1006/jmcc.1998.0829