Search Results - "Lindsey, JW"

Continuous long-term immunomodulatory therapy in relapsing multiple sclerosis: results from the 15-year analysis of the US prospective open-label study of glatiramer acetate by Ford, C., Goodman, AD, Johnson, K., Kachuck, N., Lindsey, JW, Lisak, R., Luzzio, C., Myers, L., Panitch, H., Preiningerova, J., Pruitt, A., Rose, J., Rus, H., Wolinsky, J.

“…The ongoing US Glatiramer Acetate (GA) Trial is the longest evaluation of continuous immunomodulatory therapy in relapsing—remitting multiple sclerosis (RRMS)…”
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Sudden unexpected death on fingolimod by Lindsey, JW, Haden-Pinneri, K, Memon, NB, Buja, LM

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Long-term safety and efficacy of dalfampridine for walking impairment in patients with multiple sclerosis: Results of open-label extensions of two Phase 3 clinical trials by Goodman, Andrew D, Bethoux, Francois, Brown, Theodore R, Schapiro, Randall T, Cohen, Ron, Marinucci, Lawrence N, Henney, Herbert R, Blight, Andrew R, Agius, M, Arnason, BGW, Bethoux, FA, Bever, CT, Bowen, JD, Brown, TR, Dietrich, DW, Edwards, K, Freedman, MS, Freedman, M, Kachuck, NJ, Kaufman, MD, Keilson, M, Khan, O, Krupp, LB, Leist, TP, Lindsey, JW, Lublin, FD, Mass, MK, Mattson, D, McGowan, D, Naismith, R, O’Connell, C, Oger, JJ, Panitch, H, Picone, MA, Rammohan, KW, Schapiro, RT, Schwid, SR, Scott, T, Short, C, Thrower, BW, Vollmer, TL, Camac, A, Cooper, JA, Chumley, WF, Cross, A, Dunnigan, RT, Gitt, JS, Hillen, M, Jeffrey, DR, Khatri, BO, Kresa-Reahl, K, Moon, S, Preiningerova, J, Tullman, M, Weinstock-Guttman, B, Wynn, DR

“…Background: In Phase 3 double-blind trials (MS-F203 and MS-F204), dalfampridine extended release tablets 10 mg twice daily (dalfampridine-ER; prolonged-release…”
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Quantitative PCR for Epstein–Barr virus DNA and RNA in multiple sclerosis by Lindsey, JW, Hatfield, LM, Crawford, MP, Patel, S

“…Background Epstein–Barr virus (EBV) is associated with MS, but it is not clear whether EBV plays a role in the pathogenesis of MS. Hypothesis We hypothesized…”
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PCR for bacterial 16S ribosomal DNA in multiple sclerosis cerebrospinal fluid by LINDSEY, J. W, PATEL, S

“…The cause of multiple sclerosis (MS) is currently unknown. The hypothesis of this study is that MS is caused by a chronic bacterial infection of the central…”
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Review: PCR for bacterial 16S ribosomal DNA in multiple sclerosis cerebrospinal fluid by Lindsey, JW, Patel, S.

“…The cause of multiple sclerosis (MS) is currently unknown. The hypothesis of this study is that MS is caused by a chronic bacterial infection of the central…”
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Dexamethasone-induced Ras-related protein 1 is a potential regulatory protein in B lymphocytes by Lindsey, JW

“…Dexamethasone-induced Ras-related protein 1 (RASD1) is a protein of the Ras family which probably has a regulatory function. We demonstrate that Rasd1 mRNA is…”
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Familial recurrence rates and genetic models of multiple sclerosis by Lindsey, J. William

“…Susceptibility to multiple sclerosis (MS) is determined by both inherited and non‐inherited factors. The importance of genetic factors is demonstrated by the…”
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The CombiRx trial of combined therapy with interferon and glatiramer cetate in relapsing remitting MS: Design and baseline characteristics by Lindsey, Jw, Scott, Tf, Lynch, Sg, Cofield, Ss, Nelson, F, Conwit, R, Gustafson, T, Cutter, Gr, Wolinsky, Js, Lublin, Fd

“…BACKGROUND: Interferon-β1a (IFNB) and glatiramer acetate (GA) are distinct therapies which are both partially effective for relapsing MS. It is not known if…”
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Ingested IFN-α : Results of a pilot study in relapsing-remitting MS by BROD, S. A, LINDSEY, J. W, VRIESENDORP, F. S, AHN, C, HENNINGER, E, NARAYANA, P. A, WOLINSKY, J. S

“…To investigate whether ingested human recombinant interferon-alpha2a (IFN-alpha2a) was safe and whether treatment reduces the number of gadolinium-enhanced…”
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Repeated treatment with chimeric anti-CD4 antibody in multiple sclerosis by Lindsey, J W, Hodgkinson, S, Mehta, R, Mitchell, D, Enzmann, D, Steinman, L

“…We treated 21 multiple sclerosis patients with two to four doses of cM-T412, a chimeric monoclonal antibody against the CD4 antigen found on helper/inducer T…”
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An alkali-soluble factor present in normal brain tissue inhibits antigen-specific lymphocyte proliferation by Lindsey, J.William

“…The brain has long been recognized as an immune privileged site and probably contains multiple immune regulatory factors. We have investigated the immune…”
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Diverse T cell receptor Vβ gene usage in the central nervous system in experimental allergic encephalomyelitis by BELL, R. B, LINDSEY, J. W, SOBEL, R. A, HODGKINSON, S, STEINMAN, L

“…The repertoire of TCR V beta genes transcribed and expressed within the central nervous system was determined in mice with experimental allergic…”
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Immune regulatory effects of central nervous system antigens in culture by Lindsey, J. William, Jin, Rui

“…Evidence from several different experimental systems suggests that regulatory cells specific for self-antigens exist in the normal immune repertoire, and that…”
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Use of reinduced experimental autoimmune encephalomyelitis to evaluate the importance of epitope spread by Lindsey, J W

“…Several investigators have reported experimental evidence of epitope spreading in experimental autoimmune encephalomyelitis (EAE). The role of epitope…”
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Phase 1 clinical trial of chimeric monoclonal anti-CD4 antibody in multiple sclerosis by LINDSEY, J. W, HODGKINSON, S, STEINMAN, L, MEHTA, R, SIEGEL, R. C, MITCHELL, D. J, LIM, M, PIERCY, C, TRAM, T, DORFMAN, L, ENZMANN, D

“…We conducted an open trial of cM-T412, a chimeric monoclonal anti-CD4 antibody, in 29 patients with MS. This antibody caused a prompt and long-lasting…”
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T cell-T cell activation in multiple sclerosis by Lindsey, J W, Kerman, R H, Wolinsky, J S

“…Activated T cells are able to stimulate proliferation in resting T cells through an antigen non-specific mechanism. The in vivo usefulness of this T cell-T…”
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ACUTE EFFECTS OF A BICYCLOPHOSPHATE NEUROCONVULSANT ON MONOAMINE NEUROTRANSMITTER AND METABOLITE LEVELS IN THE RAT BRAIN by Lindsey, J W, Jung, A E, Narayanan, T K, Ritchie, G D

“…Naive male Sprague-Dawley rats were injected intraperitoneally (ip) with the bicyclophosphate convulsant trimethylolpropane phosphate (TMPP) at dose levels…”
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Reinduction of Experimental Autoimmune Encephalomyelitis in Mice by Lindsey, J.William, Pappolla, Miguel, Steinman, Lawrence

“…Experimental autoimmune encephalomyelitis (EAE) in Lewis rats and some strains of mice is typically a monophasic disease, and recovered animals are resistant…”
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Tissue Distribution, Metabolism, and Clearance of the Convulsant Trimethylolpropane Phosphate in Rats by ROSSI, J. III, JUNG, A. E, RITCHIE, G. D, LINDSEY, J. W, NORDHOLM, A. F

“…The distribution, metabolism, and clearance of trimethylolpropane phosphate (TMPP), a potent, bicyclophosphate, γ-aminobutyric acid-ergic convulsant, were…”
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