Search Results - "Lindsell, Christopher J"

Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation by Hippensteel, Joseph A, Uchimido, Ryo, Tyler, Patrick D, Burke, Ryan C, Han, Xiaorui, Zhang, Fuming, McMurtry, Sarah A, Colbert, James F, Lindsell, Christopher J, Angus, Derek C, Kellum, John A, Yealy, Donald M, Linhardt, Robert J, Shapiro, Nathan I, Schmidt, Eric P

“…Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models…”
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Developing a clinically feasible personalized medicine approach to pediatric septic shock by Wong, Hector R, Cvijanovich, Natalie Z, Anas, Nick, Allen, Geoffrey L, Thomas, Neal J, Bigham, Michael T, Weiss, Scott L, Fitzgerald, Julie, Checchia, Paul A, Meyer, Keith, Shanley, Thomas P, Quasney, Michael, Hall, Mark, Gedeit, Rainer, Freishtat, Robert J, Nowak, Jeffrey, Shekhar, Raj S, Gertz, Shira, Dawson, Emily, Howard, Kelli, Harmon, Kelli, Beckman, Eileen, Frank, Erin, Lindsell, Christopher J

“…Using microarray data, we previously identified gene expression-based subclasses of septic shock with important phenotypic differences. The subclass-defining…”
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Impact of Operative Management on Recurrence of Adhesive Small Bowel Obstruction: A Longitudinal Analysis of a Statewide Database by Medvecz, Andrew J., Dennis, Bradley M., Wang, Li, Lindsell, Christopher J., Guillamondegui, Oscar D.

“…Recurrence of adhesive small bowel obstruction (ASBO) can lead to multiple admissions. There is limited knowledge of the role of operative and nonoperative…”
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Emergency Department Prescription Opioids as an Initial Exposure Preceding Addiction by Butler, Megan M., BS, Ancona, Rachel M., BS, Beauchamp, Gillian A., MD, Yamin, Cyrus K., MD, Winstanley, Erin L., PhD, Hart, Kimberly W., MA, Ruffner, Andrew H., MA, LSW, Ryan, Shawn W., MD, MBA, Ryan, Richard J., MD, Lindsell, Christopher J., PhD, Lyons, Michael S., MD, MPH

“…Study objective Opioid abuse and overdose constitute an ongoing health emergency. Many presume opioids have little potential for iatrogenic addiction when used…”
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Efficacy and safety of dapagliflozin in acute heart failure: Rationale and design of the DICTATE-AHF trial by Cox, Zachary L, Collins, Sean P, Aaron, Mark, Hernandez, Gabriel A, III, A Thomas McRae, Davidson, Beth T, Fowler, Mike, Lindsell, Christopher J, Jr, Frank E Harrell, Jenkins, Cathy A, Kampe, Christina, Miller, Karen F, Stubblefield, William B, Lindenfeld, JoAnn

“…Dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, reduces cardiovascular death and worsening heart failure in patients with chronic heart failure and…”
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Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c by Cohen, Robert M., Franco, Robert S., Khera, Paramjit K., Smith, Eric P., Lindsell, Christopher J., Ciraolo, Peter J., Palascak, Mary B., Joiner, Clinton H.

“…Although red blood cell (RBC) life span is a known determinant of percentage hemoglobin A1c (HbA1c), its variation has been considered insufficient to affect…”
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Prospective, Randomized, Single-Blinded Comparative Trial of Intravenous Levetiracetam Versus Phenytoin for Seizure Prophylaxis by Szaflarski, Jerzy P., Sangha, Kiranpal S., Lindsell, Christopher J., Shutter, Lori A.

“…Background Anti-epileptic drugs are commonly used for seizure prophylaxis after neurological injury. We performed a study comparing intravenous (IV)…”
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Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective observational study by Atreya, Mihir R, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Weiss, Scott L, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L, Thomas, Neal J, Grunwell, Jocelyn R, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Lindsell, Christopher J, Alder, Matthew N, Wong, Hector R

“…Abstract Background Multiple organ dysfunction syndrome (MODS) is a critical driver of sepsis morbidity and mortality in children. Early identification of…”
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Upstrapping to determine futility: predicting future outcomes nonparametrically from past data by Wild, Jessica L, Ginde, Adit A, Lindsell, Christopher J, Kaizer, Alexander M

“…Clinical trials often involve some form of interim monitoring to determine futility before planned trial completion. While many options for interim monitoring…”
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Delirium as a predictor of mortality and disability among hospitalized patients in Zambia by Banerdt, Justin K, Mateyo, Kondwelani, Wang, Li, Lindsell, Christopher J, Riviello, Elisabeth D, Saylor, Deanna, Heimburger, Douglas C, Ely, E Wesley

“…To study the epidemiology and outcomes of delirium among hospitalized patients in Zambia. We conducted a prospective cohort study at the University Teaching…”
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The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial by Hager, David N, Hooper, Michael H, Bernard, Gordon R, Busse, Laurence W, Ely, E Wesley, Fowler, Alpha A, Gaieski, David F, Hall, Alex, Hinson, Jeremiah S, Jackson, James C, Kelen, Gabor D, Levine, Mark, Lindsell, Christopher J, Malone, Richard E, McGlothlin, Anna, Rothman, Richard E, Viele, Kert, Wright, David W, Sevransky, Jonathan E, Martin, Greg S

“…Sepsis accounts for 30% to 50% of all in-hospital deaths in the United States. Other than antibiotics and source control, management strategies are largely…”
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Timing of Advanced Airway Placement after Witnessed Out-of-Hospital Cardiac Arrest by Benoit, Justin L., McMullan, Jason T., Wang, Henry E., Xie, Changchun, Xu, Peixin, Hart, Kimberly W., Stolz, Uwe, Lindsell, Christopher J.

“…Background: Advanced airways (endotracheal tubes, supraglottic airways) are frequently placed by Emergency Medical Services (EMS) in patients with…”
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Protocol and statistical analysis plan for the Pragmatic Investigation of optimaL Oxygen Targets (PILOT) clinical trial by Semler, Matthew W, Casey, Jonathan D, Lloyd, Bradley D., Hastings, Pamela G., Hays, Margaret, Roth, Megan, Stollings, Joanna, Brems, John, Buell, Kevin George, Wang, Li, Lindsell, Christopher J., Freundlich, Robert E., Wanderer, Jonathan P., Bernard, Gordon R., Self, Wesley H., Rice, Todd W., Freundlich, Robert E, Wanderer, Jonathan P, J Lindsell, Christopher, H Han, Jin, Self, Wesley H, Brems, John H, Buell, Kevin G, Patel, Sneha, Stollings, Joanna L, Bernard, Gordon R, Casey, Jonathan D, Cleveland, Christina, Hays, Margaret A, Huerta, Luis E, Jackson, Karen, Rice, Todd W, Roth, Megan, Semler, Matthew W, Hastings, Pamela G, D Lloyd, Bradley, Richardson, Roger K, Craig Rooks, J

“…IntroductionMechanical ventilation of intensive care unit (ICU) patients universally involves titration of the fraction of inspired oxygen to maintain arterial…”
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Lopinavir/ritonavir for treatment of non-hospitalized patients with COVID-19: a randomized clinical trial by Kaizer, Alexander M., Shapiro, Nathan I., Wild, Jessica, Brown, Samuel M., Cwik, B. Jessica, Hart, Kimberly W., Jones, Alan E., Pulia, Michael S., Self, Wesley H., Smith, Clay, Smith, Stephanie A., Ng, Patrick C., Thompson, B. Taylor, Rice, Todd W., Lindsell, Christopher J., Ginde, Adit A.

“…•Randomized, placebo-controlled trial of lopinavir/ritonavir against COVID-19.•Enrolled outpatient participants within 6 days of positive SARS-CoV-2 antigen…”
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Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model by Wong, Hector R, Weiss, Scott L, Giuliano, Jr, John S, Wainwright, Mark S, Cvijanovich, Natalie Z, Thomas, Neal J, Allen, Geoffrey L, Anas, Nick, Bigham, Michael T, Hall, Mark, Freishtat, Robert J, Sen, Anita, Meyer, Keith, Checchia, Paul A, Shanley, Thomas P, Nowak, Jeffrey, Quasney, Michael, Chopra, Arun, Fitzgerald, Julie C, Gedeit, Rainer, Banschbach, Sharon, Beckman, Eileen, Lahni, Patrick, Hart, Kimberly, Lindsell, Christopher J

“…We previously derived and validated a risk model to estimate mortality probability in children with septic shock (PERSEVERE; PEdiatRic SEpsis biomarkEr Risk…”
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Robotic versus Electromagnetic bronchoscopy for pulmonary LesIon AssessmeNT: the RELIANT pragmatic randomized trial by Paez, Rafael, Lentz, Robert J, Salmon, Cristina, Siemann, Justin K, Low, See-Wei, Casey, Jonathan D, Chen, Heidi, Chen, Sheau-Chiann, Avasarala, Sameer, Shojaee, Samira, Rickman, Otis B, Lindsell, Christopher J, Gatto, Cheryl L, Rice, Todd W, Maldonado, Fabien

“…Robotic-assisted bronchoscopy has recently emerged as an alternative to electromagnetic navigational bronchoscopy for the evaluation of peripheral pulmonary…”
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We know what we want, it's just not there by Freundlich, Robert E, Lindsell, Christopher J

“…The systolic and diastolic blood pressure may be merged into one cell, separated by a dash – easy enough to fix with a few lines of code. [...]our experience…”
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Modeling the Impacts of Clinical Influenza Testing on Influenza Vaccine Effectiveness Estimates by Feldstein, Leora R, Ferdinands, Jill M, Self, Wesley H, Randolph, Adrienne G, Aboodi, Michael, Baughman, Adrienne H, Brown, Samuel M, Exline, Matthew C, Clark Files, D, Gibbs, Kevin, Ginde, Adit A, Gong, Michelle N, Grijalva, Carlos G, Halasa, Natasha, Khan, Akram, Lindsell, Christopher J, Newhams, Margaret, Peltan, Ithan D, Prekker, Matthew E, Rice, Todd W, Shapiro, Nathan I, Steingrub, Jay, Talbot, H Keipp, Halloran, M Elizabeth, Patel, Manish

“…Abstract Background Test-negative design studies for evaluating influenza vaccine effectiveness (VE) enroll patients with acute respiratory infection…”
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Corticosteroids and pediatric septic shock outcomes: a risk stratified analysis by Atkinson, Sarah J, Cvijanovich, Natalie Z, Thomas, Neal J, Allen, Geoffrey L, Anas, Nick, Bigham, Michael T, Hall, Mark, Freishtat, Robert J, Sen, Anita, Meyer, Keith, Checchia, Paul A, Shanley, Thomas P, Nowak, Jeffrey, Quasney, Michael, Weiss, Scott L, Banschbach, Sharon, Beckman, Eileen, Howard, Kelli, Frank, Erin, Harmon, Kelli, Lahni, Patrick, Lindsell, Christopher J, Wong, Hector R

“…The potential benefits of corticosteroids for septic shock may depend on initial mortality risk. We determined associations between corticosteroids and…”
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Endovascular Treatment for Acute Stroke Patients With a Pre-stroke Disability: An International Survey by Salwi, Sanjana, Niec, Jan A., Hassan, Ameer E., Lindsell, Christopher J., Khatri, Pooja, Mocco, J., Saver, Jeffrey L., Mistry, Eva A.

“…Background: It is unclear what factors clinicians consider when deciding about endovascular thrombectomy (EVT) in acute ischemic stroke patients with a…”
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