Clinical care pathway for the evaluation of patients with suspected VITT after ChAdOx1 nCoV-19 vaccination

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare complication after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adenoviral vector vaccination. In British Columbia (BC), Canada, a provincial clinical care pathway was developed to guide clinicians in evaluating for...

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Published in:	Blood advances Vol. 6; no. 11; pp. 3315 - 3320
Main Authors:	Lee, Agnes Y.Y., Al Moosawi, Muntadhar, Peterson, Erica A., McCracken, Rita K., Wong, Steven K.W., Nicolson, Hamish, Chan, Vicky, Smith, Tyler, Wong, Michelle P., Lee, Lauren J., Griffiths, Cameron, Rahal, Bhavdeep, Parkin, Stephen, Afra, Kevin, Ambler, Kimberley, Chen, Luke Y.C., Field, Thalia S., Lindsay, Heather C., Lavoie, Martin, Li, Charles, Migneault, David, Naus, Monika, Piszczek, Jolanta, Rahmani, Poupak, Sreenivasan, Gayatri, Wan, Tony, Yee, Adrian, Zypchen, Leslie, Sweet, David
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 14-06-2022 American Society of Hematology
Subjects:	Stimulus Report
Online Access:	Get full text
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Summary:	Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare complication after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adenoviral vector vaccination. In British Columbia (BC), Canada, a provincial clinical care pathway was developed to guide clinicians in evaluating for VITT among patients who present with thrombocytopenia or thrombosis symptoms within 4 to 28 days after adenoviral vector vaccine exposure. All patients had enzyme-linked immunosorbent assay (ELISA) testing for platelet factor 4 (PF4) antibodies, and all cases with positive PF4-ELISA or d-dimer levels ≥2.0 mg/L fibrinogen equivalent units (FEU) had further testing for platelet-activating PF4 antibodies using a modified serotonin release assay (SRA). Between 1 May and 30 June 2021, 37% of 68 patients investigated for VITT had thrombosis, but only 3 had VITT confirmed by PF4-ELISA and SRA. Platelet counts, d-dimer levels, and ELISA optical density values were significantly different between those with and without VITT. Three patients had thrombocytopenia and thrombosis with d-dimer levels >4.0 mg/L FEU but had negative PF4-ELISA and SRA results. Patients with VITT were treated successfully with IV immunoglobulin, nonheparin anticoagulants, and corticosteroids. Our pathway demonstrated that thrombosis is common among patients investigated for VITT and that PF4-ELISA testing is necessary to confirm VITT in those presenting with thrombosis and thrombocytopenia. •A clinical care pathway using centralized PF4-ELISA testing detected a 37% prevalence of thrombosis among patients investigated for VITT.•VITT should be confirmed by PF4-ELISA as thrombosis with thrombocytopenia can occur without PF4 antibodies after SARS-CoV-2 vaccination.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Requests for data sharing may be submitted to Agnes Y. Y. Lee (alee14@bccancer.bc.ca).
ISSN:	2473-9529 2473-9537
DOI:	10.1182/bloodadvances.2021006862