Search Results - "Lindquist, Jonathan A"

Cold shock proteins: from cellular mechanisms to pathophysiology and disease by Lindquist, Jonathan A, Mertens, Peter R

“…Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the presence of one or more cold shock domains. In humans, the best…”
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A methodology for the structural and functional analysis of signaling and regulatory networks by Klamt, Steffen, Saez-Rodriguez, Julio, Lindquist, Jonathan A, Simeoni, Luca, Gilles, Ernst D

“…Structural analysis of cellular interaction networks contributes to a deeper understanding of network-wide interdependencies, causal relationships, and basic…”
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Activated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protein-1 Ubiquitination by Dong, Wei, Wang, Hongjie, Shahzad, Khurrum, Bock, Fabian, Al-Dabet, Moh'd Mohanad, Ranjan, Satish, Wolter, Juliane, Kohli, Shrey, Hoffmann, Juliane, Dhople, Vishnu Mukund, Zhu, Cheng, Lindquist, Jonathan A, Esmon, Charles T, Gröne, Elisabeth, Gröne, Herman-Josef, Madhusudhan, Thati, Mertens, Peter R, Schlüter, Dirk, Isermann, Berend

“…Ischemia-reperfusion injury (IRI) is the leading cause of ARF. A pathophysiologic role of the coagulation system in renal IRI has been established, but the…”
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A logical model provides insights into T cell receptor signaling by Saez-Rodriguez, Julio, Simeoni, Luca, Lindquist, Jonathan A, Hemenway, Rebecca, Bommhardt, Ursula, Arndt, Boerge, Haus, Utz-Uwe, Weismantel, Robert, Gilles, Ernst D, Klamt, Steffen, Schraven, Burkhart

“…Cellular decisions are determined by complex molecular interaction networks. Large-scale signaling networks are currently being reconstructed, but the kinetic…”
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YB-1 Is Altered in Pregnancy-Associated Disorders and Affects Trophoblast in Vitro Properties via Alternation of Multiple Molecular Traits by Stojanovska, Violeta, Shah, Aneri, Woidacki, Katja, Fischer, Florence, Bauer, Mario, Lindquist, Jonathan A., Mertens, Peter R., Zenclussen, Ana C.

“…Cold shock Y-box binding protein-1 (YB-1) coordinates several molecular processes between the nucleus and the cytoplasm and plays a crucial role in cell…”
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YB-1 Interferes with TNFα-TNFR Binding and Modulates Progranulin-Mediated Inhibition of TNFα Signaling by Hessman, Christopher L, Hildebrandt, Josephine, Shah, Aneri, Brandt, Sabine, Bock, Antonia, Frye, Björn C, Raffetseder, Ute, Geffers, Robert, Brunner-Weinzierl, Monika C, Isermann, Berend, Mertens, Peter R, Lindquist, Jonathan A

“…Inflammation and an influx of macrophages are common elements in many diseases. Among pro-inflammatory cytokines, tumor necrosis factor α (TNFα) plays a…”
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DNA-Binding Protein A Is Actively Secreted in a Calcium-and Inflammasome-Dependent Manner and Negatively Influences Tubular Cell Survival by Hoppstock, Gregor, Lindquist, Jonathan A, Willems, Antonia, Becker, Annika, Reichardt, Charlotte, Morgenroth, Ronnie, Stolze, Saskia, Zhu, Cheng, Brandt, Sabine, Mertens, Peter R

“…DNA-binding protein A (DbpA) belongs to the Y-box family of cold shock domain (CSD) proteins that bind RNA/DNA and exert intracellular functions in cell…”
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Cold Shock Domain Protein DbpA Orchestrates Tubular Cell Damage and Interstitial Fibrosis in Inflammatory Kidney Disease by Lindquist, Jonathan A, Bernhardt, Anja, Reichardt, Charlotte, Sauter, Eva, Brandt, Sabine, Rana, Rajiv, Lindenmeyer, Maja T, Philipsen, Lars, Isermann, Berend, Zhu, Cheng, Mertens, Peter R

“…DNA-binding protein A (DbpA) belongs to the Y-box family of cold shock domain proteins that exert transcriptional and translational activities in the cell via…”
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Comparative Analysis of Acute Kidney Injury Models and Related Fibrogenic Responses: Convergence on Methylation Patterns Regulated by Cold Shock Protein by Brandt, Sabine, Bernhardt, Anja, Häberer, Saskia, Wolters, Katharina, Gehringer, Fabian, Reichardt, Charlotte, Krause, Anna, Geffers, Robert, Kahlfuß, Sascha, Jeron, Andreas, Bruder, Dunja, Lindquist, Jonathan A, Isermann, Berend, Mertens, Peter R

“…Fibrosis is characterized by excessive extracellular matrix formation in solid organs, disrupting tissue architecture and function. The Y-box binding protein-1…”
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Y-Box Binding Protein 1 Expression in Trophoblast Cells Promotes Fetal and Placental Development by Meyer, Nicole, Schumacher, Anne, Coenen, Urs, Woidacki, Katja, Schmidt, Hannah, Lindquist, Jonathan A, Mertens, Peter R, Zenclussen, Ana C

“…Y-box binding protein 1 (YB-1) is pivotal for the regulation of cancerogenesis and inflammation. However, its involvement in pregnancy processes such as fetal…”
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Fyn Regulates the Duration of TCR Engagement Needed for Commitment to Effector Function by Filby, Andrew, Seddon, Benedict, Kleczkowska, Joanna, Salmond, Robert, Tomlinson, Peter, Smida, Michal, Lindquist, Jonathan A, Schraven, Burkhart, Zamoyska, Rose

“…In naive T cells, engagement of the TCR with agonist peptide:MHC molecules leads to phosphorylation of key intracellular signaling intermediates within seconds…”
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Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation by Lindquist, Sabine, Karitkina, Diana, Langnaese, Kristina, Posevitz-Fejfar, Anita, Schraven, Burkhart, Xavier, Ramnik, Seed, Brian, Lindquist, Jonathan A

“…Src family kinases (SFK) control multiple processes during brain development and function. We show here that the phosphoprotein associated with…”
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Integrating signals from the T-cell receptor and the interleukin-2 receptor by Beyer, Tilo, Busse, Mandy, Hristov, Kroum, Gurbiel, Slavyana, Smida, Michal, Haus, Utz-Uwe, Ballerstein, Kathrin, Pfeuffer, Frank, Weismantel, Robert, Schraven, Burkhart, Lindquist, Jonathan A

“…T cells orchestrate the adaptive immune response, making them targets for immunotherapy. Although immunosuppressive therapies prevent disease progression, they…”
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Control of lymphocyte development and activation by negative regulatory transmembrane adapter proteins by Simeoni, Luca, Lindquist, Jonathan A, Smida, Michal, Witte, Vanessa, Arndt, Boerge, Schraven, Burkhart

“…Signals emanating from antigen receptors critically regulate immune cell activation, survival, and differentiation. Transmembrane adapter proteins (TRAPs), a…”
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Decreased iNOS synthesis mediates dexamethasone-induced protection of neurons from inflammatory injury in vitro by Golde, Sabine, Coles, Alasdair, Lindquist, Jonathan A., Compston, Alastair

“…Brain inflammation is accompanied by transection of axons and death of neurons in the acute lesions of multiple sclerosis. We explored mechanisms of…”
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A displaced PAG enhances proximal signaling and SDF‐1‐induced T cell migration by Posevitz‐Fejfár, Anita, Šmída, Michal, Kliche, Stefanie, Hartig, Roland, Schraven, Burkhart, Lindquist, Jonathan A.

“…PAG, the phosphoprotein associated with glycosphingolipid‐enriched microdomains (GEM), negatively regulates Src family kinases by recruiting C‐terminal Src…”
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DNA-binding protein-A promotes kidney ischemia/reperfusion injury and participates in mitochondrial function by Reichardt, Charlotte, Brandt, Sabine, Bernhardt, Anja, Krause, Anna, Lindquist, Jonathan A, Weinert, Sönke, Geffers, Robert, Franz, Tobias, Kahlfuss, Sascha, Dudeck, Anne, Mathew, Akash, Rana, Rajiv, Isermann, Berend, Mertens, Peter R

“…DNA-binding protein-A (DbpA; gene: Ybx3) belongs to the cold shock protein family with known functions in cell cycling, transcription, translation, and tight…”
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Excessive sodium chloride ingestion promotes inflammation and kidney fibrosis in aging mice by Bernhardt, Anja, Krause, Anna, Reichardt, Charlotte, Steffen, Hannes, Isermann, Berend, Völker, Uwe, Hammer, Elke, Geffers, Robert, Philipsen, Lars, Dhjamandi, Kristin, Ahmad, Sohail, Brandt, Sabine, Lindquist, Jonathan A, Mertens, Peter R

“…In aging kidneys, a decline of function resulting from extracellular matrix (ECM) deposition and organ fibrosis is regarded as "physiological." Whether a…”
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Farnesoid X Receptor Agonism Protects against Diabetic Tubulopathy: Potential Add-On Therapy for Diabetic Nephropathy by Marquardt, Andi, Al-Dabet, Moh'd Mohanad, Ghosh, Sanchita, Kohli, Shrey, Manoharan, Jayakumar, ElWakiel, Ahmed, Gadi, Ihsan, Bock, Fabian, Nazir, Sumra, Wang, Hongjie, Lindquist, Jonathan A, Nawroth, Peter Paul, Madhusudhan, Thati, Mertens, Peter R, Shahzad, Khurrum, Isermann, Berend

“…Established therapies for diabetic nephropathy (dNP) delay but do not prevent its progression. The shortage of established therapies may reflect the inability…”
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Glomerular-tubular crosstalk via cold shock Y-box binding protein-1 in the kidney by Rana, Rajiv, Manoharan, Jayakumar, Elwakiel, Ahmed, Zimmermann, Silke, Lindquist, Jonathan A, Gupta, Dheerendra, Al-Dabet, Moh'd Mohanad, Gadi, Ihsan, Fallmann, Jörg, Singh, Kunal, Gupta, Anubhuti, Biemann, Ronald, Brandt, Sabine, Alo, Bekas, Kluge, Paul, Garde, Ravindra, Lamers, Christina, Shahzad, Khurrum, Künze, Georg, Kohli, Shrey, Mertens, Peter R, Isermann, Berend

“…Glomerular-tubular crosstalk within the kidney has been proposed, but the paracrine signals enabling this remain largely unknown. The cold-shock protein Y-box…”
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