Search Results - "Lindon, J.C"

Pattern recognition methods and applications in biomedical magnetic resonance by Lindon, J.C., Holmes, E., Nicholson, J.K.

“…Multivariate statistical methods, sometimes termed as chemometrics or bio-informatics, have been used to extract information from high resolution nuclear…”
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An NMR-based metabonomic approach to the investigation of coelomic fluid biochemistry in earthworms under toxic stress by Bundy, J.G, Osborn, D, Weeks, J.M, Lindon, J.C, Nicholson, J.K

“…The endogenous metabolites of the coelomic fluid of the earthworm Eisenia veneta were characterised using high-resolution one-dimensional and two-dimensional…”
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A comparison of quantitative NMR and radiolabelling studies of the metabolism and excretion of Statil™ (3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid) in the rat by Lenz, E.M, Wilson, I.D, Wright, B, Partridge, E.A, Rodgers, C.T, Haycock, P.R, Lindon, J.C, Nicholson, J.K

“…The identification and quantitation of the metabolites of Statil™ in rat bile and urine were investigated by 1H- and 19F-NMR spectroscopy and liquid…”
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Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles by Akhbari, P., Jaggard, M.K., Boulangé, C.L., Vaghela, U., Graça, G., Bhattacharya, R., Lindon, J.C., Williams, H.R.T., Gupte, C.M.

“…The hip and knee joints differ biomechanically in terms of contact stresses, fluid lubrication and wear patterns. These differences may be reflected in the…”
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A systematic review of the small molecule studies of osteoarthritis using nuclear magnetic resonance and mass spectroscopy by Jaggard, M.K.J., Boulangé, C.L., Akhbari, P., Vaghela, U., Bhattacharya, R., Williams, H.R.T., Lindon, J.C., Gupte, C.M.

“…To perform a systematic review of the small molecule metabolism studies of osteoarthritis utilising nuclear magnetic resonance (NMR) or mass spectroscopy (MS)…”
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The biochemical profile of rat testicular tissue as measured by magic angle spinning 1H NMR spectroscopy by Griffin, J.L., Troke, J., Walker, L.A., Shore, R.F., Lindon, J.C., Nicholson, J.K.

“…The testis is the principal organ of male fertility, responsible for the production of spermatozoa and their maturation into sperm. However, the underlying…”
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Colonization-induced host-gut microbial metabolic interaction by Claus, Sandrine P, Ellero, Sandrine L, Berger, Bernard, Krause, Lutz, Bruttin, Anne, Molina, Jérôme, Paris, Alain, Want, Elizabeth J, de Waziers, Isabelle, Cloarec, Olivier, Richards, Selena E, Wang, Yulan, Dumas, Marc-Emmanuel, Ross, Alastair, Rezzi, Serge, Kochhar, Sunil, Van Bladeren, Peter, Lindon, John C, Holmes, Elaine, Nicholson, Jeremy K

“…The gut microbiota enhances the host's metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of…”
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Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model by Fay, Laurent B, Kochhar, Sunil, Wang, Yulan, Rezzi, Serge, Yap, Ivan K S, Lundstedt, Torbjörn, Lek, Per, van Bladeren, Peter, Martin, Francois-Pierre J, Sprenger, Norbert, Ramadan, Ziad, Nicholson, Jeremy K, Lindon, John C, Holmes, Elaine

“…The transgenomic metabolic effects of exposure to either Lactobacillus paracasei or Lactobacillus rhamnosus probiotics have been measured and mapped in…”
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So what's the deal with metabonomics? by LINDON, John C, HOLMES, Elaine, NICHOLSON, Jeremy K

“…Metabonomics measures the fingerprint of biochemical perturbations caused by disease, drugs, and toxins. Research in metabonomics is discussed…”
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The challenges of modeling mammalian biocomplexity by Nicholson, Jeremy K, Holmes, Elaine, Lindon, John C, Wilson, Ian D

“…Understanding the relationships between human genetic factors, the risks of developing major diseases and the molecular basis of drug efficacy and toxicity is…”
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NMR spectroscopic studies on the haemolymph of the tobacco hornworm, Manduca sexta: assignment of 1H and 13C NMR spectra by Phalaraksh, C., Lenz, E.M., Lindon, J.C., Nicholson, J.K., Farrant, R.D., Reynolds, S.E., Wilson, I.D., Osborn, D., Weeks, J.M.

“…High resolution 1H nuclear magnetic resonance (NMR) spectroscopy has been used to investigate the low molecular weight metabolite composition of the whole…”
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High-resolution magic angle spinning1H NMR spectroscopic studies on intact rat renal cortex and medulla by Garrod, S., Humpfer, E., Spraul, M., Connor, S.C., Polley, S., Connelly, J., Lindon, J.C., Nicholson, J.K., Holmes, E.

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Automatic data reduction and pattern recognition methods for analysis of 1H nuclear magnetic resonance spectra of human urine from normal and pathological states by Holmes, E, Foxall, P J, Nicholson, J K, Neild, G H, Brown, S M, Beddell, C R, Sweatman, B C, Rahr, E, Lindon, J C, Spraul, M

“…Multivariate data analysis techniques have been used to compare 600-MHz 1H nuclear magnetic resonance (NMR) spectra of urine obtained from patients with inborn…”
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Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography–mass spectrometry–nuclear magnetic resonance spectroscopy by Dear, G.J., Plumb, R.S., Sweatman, B.C., Ayrton, J., Lindon, J.C., Nicholson, J.K., Ismail, I.M.

“…Mass spectrometry (both MS and MS–MS) has been used to determine which eluting chromatography peaks in an LC–MS–nuclear magnetic resonance (NMR) experiment…”
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A QSAR investigation of dermal and respiratory chemical sensitizers based on computational chemistry properties by Warne, M.A., Nicholson, J.K., Lindon, J.C., Guiney, P.D., Gartland, K.P.R.

“…A wide range of physicochemical properties based on molecular topology, size and shape, and semi-empirical molecular orbital theory were calculated for a…”
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Investigations into Biochemical Changes Due to Diurnal Variation and Estrus Cycle in Female Rats Using High-Resolution 1H NMR Spectroscopy of Urine and Pattern Recognition by Bollard, M.E., Holmes, E., Lindon, J.C., Mitchell, S.C., Branstetter, D., Zhang, W., Nicholson, J.K.

“…Metabonomic methods utilizing 1H NMR spectroscopy and pattern recognition analysis (NMR-PR) have been applied to investigate biochemical variation in a control…”
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The biochemical profile of rat testicular tissue as measured by magic angle spinning 1 H NMR spectroscopy by Griffin, J.L., Troke, J., Walker, L.A., Shore, R.F., Lindon, J.C., Nicholson, J.K.

“…The testis is the principal organ of male fertility, responsible for the production of spermatozoa and their maturation into sperm. However, the underlying…”
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High-resolution1H and1H-13C magic angle spinning NMR spectroscopy of rat liver by Bollard, M.E., Garrod, S., Holmes, E., Lindon, J.C., Humpfer, E., Spraul, M., Nicholson, J.K.

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The metabolism of 2-trifluormethylaniline and its acetanilide in the rat by 19F NMR monitored enzyme hydrolysis and 1H/19F HPLC-NMR spectroscopy by Tugnait, M, Lenz, E.M, Hofmann, M, Spraul, M, Wilson, I.D, Lindon, J.C, Nicholson, J.K

“…The urinary excretion profile and identity of the metabolites of 2-trifluoromethyl aniline (2-TFMA) and 2-trifluoromethyl acetanilide (2-TFMAc), following i.p…”
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Automatic reduction of NMR spectroscopic data for statistical and pattern recognition classification of samples by Spraul, M, Neidig, P, Klauck, U, Kessler, P, Holmes, E, Nicholson, J K, Sweatman, B C, Salman, S R, Farrant, R D, Rahr, E

“…A general method of automatically reducing NMR spectra to provide numerical descriptors of samples has been developed and investigated. These descriptors can…”
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