Search Results - "Lindley, Robyn A"

The importance of codon context for understanding the Ig-like somatic hypermutation strand-biased patterns in TP53 mutations in breast cancer by Lindley, Robyn A

“…Evidence already exists that the activation-induced deaminase (AID)/APOBEC family constitutes a set of differentially expressed enzymes capable of deaminating…”
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A proposed reverse transcription mechanism for (CAG)n and similar expandable repeats that cause neurological and other diseases by Franklin, Andrew, Steele, Edward J., Lindley, Robyn A.

“…The mechanism of (CAG)n repeat generation, and related expandable repeat diseases in non-dividing cells, is currently understood in terms of a DNA…”
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Association between targeted somatic mutation (TSM) signatures and HGS‐OvCa progression by Lindley, Robyn A., Humbert, Patrick, Larner, Cliff, Akmeemana, Eric H., Pendlebury, Christopher R. R.

“…Evidence already exists that the activation‐induced cytidine deaminase (AID/APOBEC) and the adenosine deaminase (ADAR) families of enzymes are implicated as…”
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Somatic mutation patterns at Ig and Non-Ig Loci by Steele, Edward J, Franklin, Andrew, Lindley, Robyn A

“…The reverse transcriptase (RT) model of immunoglobulin (Ig) somatic hypermutation (SHM) has received insufficient scientific attention. This is understandable…”
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Molecular model linking Th2 polarized M2 tumour‐associated macrophages with deaminase‐mediated cancer progression mutation signatures by Mamrot, Jared, Balachandran, Siddharth, Steele, Edward J., Lindley, Robyn A.

“…A new and diverse range of somatic mutation signatures are observed in late‐stage cancers, but the underlying reasons are not fully understood. We advance a…”
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Analysis of SARS‐CoV‐2 haplotypes and genomic sequences during 2020 in Victoria, Australia, in the context of putative deficits in innate immune deaminase anti‐viral responses by Lindley, Robyn A., Steele, Edward J.

“…The SARS‐CoV‐2 epidemic infections in Australia during 2020 were small in number in epidemiological terms and are well described. The SARS‐CoV‐2 genomic…”
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Natural Antibodies and Severe Acute Respiratory Syndrome Coronavirus 2–Specific Antibodies in Healthy Asymptomatic Individuals by Steele, Edward J, Gorczynski, Reginald M, Lindley, Robyn A, Chandra Wickramasinghe, N

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ADAR deaminase A-to-I editing of DNA and RNA moieties of RNA:DNA hybrids has implications for the mechanism of Ig somatic hypermutation by Steele, Edward J., Lindley, Robyn A.

“…The implications are discussed of recently published biochemical studies on ADAR-mediated A-to-I DNA and RNA deamination at RNA:DNA hybrids. The significance…”
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Predicting clinical outcomes using cancer progression associated signatures by Mamrot, Jared, Hall, Nathan E, Lindley, Robyn A

“…Somatic mutation signatures are an informative facet of cancer aetiology, however they are rarely useful for predicting patient outcome. The aim of this study…”
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Lamarck and Panspermia - On the Efficient Spread of Living Systems Throughout the Cosmos by Steele, Edward J., Gorczynski, Reginald M., Lindley, Robyn A., Liu, Yongsheng, Temple, Robert, Tokoro, Gensuke, Wickramasinghe, Dayal T., Wickramasinghe, N. Chandra

“…We review the main lines of evidence (molecular, cellular and whole organism) published since the 1970s demonstrating Lamarckian Inheritance in animals, plants…”
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Regulatory T cells and co‐evolution of allele‐specific MHC recognition by the TCR by Steele, Edward J., Lindley, Robyn A.

“…What is the evolutionary mechanism for the TCR‐MHC‐conserved interaction? We extend Dembic's model (Dembic Z. In, Scand J Immunol e12806, 2019) of thymus…”
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Origin of new emergent Coronavirus and Candida fungal diseases-Terrestrial or cosmic? by Steele, Edward J, Gorczynski, Reginald M, Lindley, Robyn A, Tokoro, Gensuke, Temple, Robert, Wickramasinghe, N Chandra

“…The origins and global spread of two recent, yet quite different, pandemic diseases is discussed and reviewed in depth: Candida auris, a eukaryotic fungal…”
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APOBEC and ADAR deaminases may cause many single nucleotide polymorphisms curated in the OMIM database by Lindley, Robyn A, Hall, Nathan E

“…Cytosine and adenosine deamination events (DNA, RNA substrates) account for most codon-context Targeted Somatic Mutation (TSM) patterns observed in…”
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Nature of Acquired Immune Responses, Epitope Specificity and Resultant Protection from SARS-CoV-2 by Gorczynski, Reginald M, Lindley, Robyn A, Steele, Edward J, Wickramasinghe, Nalin Chandra

“…The primary global response to the SARS-CoV-2 pandemic has been to bring to the clinic as rapidly as possible a number of vaccines that are predicted to…”
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Blood and saliva-derived exomes from healthy Caucasian subjects do not display overt evidence of somatic mosaicism by Hall, Nathan E, Mamrot, Jared, Frampton, Chris, Read, Prue, Steele, Edward J, Bischof, Robert J, Lindley, Robyn A

“…Somatic mosaicism is a normal occurrence during development in the tissues and organs. As part of establishing a "healthy population "(HP) background or…”
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Somatic mutation patterns in non-lymphoid cancers resemble the strand biased somatic hypermutation spectra of antibody genes by Steele, Edward J., Lindley, Robyn A.

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Somatic hypermutation and the discovery of A-to-I RNA editing sites? by Steele, Edward J., Lindley, Robyn A., Weiller, Georg W.

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The efficient Lamarckian spread of life in the cosmos by Steele, Edward J, Gorczynski, Reginald M, Lindley, Robyn A, Liu, Yongsheng, Temple, Robert, Tokoro, Gensuke, Wickramasinghe, Dayal T, Wickramasinghe, N Chandra

“…In this Chapter we discuss the various mechanisms that are available for the possible transfer of cosmic microbial living systems from one cosmic habitat to…”
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Computational analyses show A-to-G mutations correlate with nascent mRNA hairpins at somatic hypermutation hotspots by Steele, Edward J., Lindley, Robyn A., Wen, Jiayu, Weiller, Georg F.

“…Activation-induced cytidine deaminase (AID) initiates Phase I somatic hypermutation (SHM) of antibody genes by deaminating deoxy-cytosine to deoxy-uracil…”
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Genesis of ancestral haplotypes: RNA modifications and reverse transcription–mediated polymorphisms by Steele, Edward J, Williamson, Joseph F, Lester, Susan, Stewart, Brent J, Millman, John A, Carnegie, Pat, Lindley, Robyn A, Pain, Geoff N, Dawkins, Roger L

“…Abstract Understanding the genesis of the block haplotype structure of the genome is a major challenge. With the completion of the sequencing of the Human…”
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