Search Results - "Lindgren, Joel"

Intramolecular Thioether Crosslinking to Increase the Proteolytic Stability of Affibody Molecules by Nilsson, Anders, Lindgren, Joel, Eriksson Karlström, Amelie

“…Protein therapeutics suffer from low oral bioavailability, mainly due to poor membrane permeability and digestion by gastrointestinal proteases. To improve…”
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Intramolecular Thioether Crosslinking To Increase The Protease Stability Of Small Therapeutic Proteins by Lindgren, Joel, Eriksson Karlström, Amelie

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In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1 by Rubins, Daniel J, Meng, Xiangjun, McQuade, Paul, Klimas, Michael, Getty, Krista, Lin, Shu-An, Connolly, Brett M., O’Malley, Stacey S., Haley, Hyking, Purcell, Mona, Gantert, Liza, Holahan, Marie, Lindgren, Joel, Eklund, Pär, Ekblad, Caroline, Frejd, Fredrik Y., Hostetler, Eric D., González Trotter, Dinko E., Evelhoch, Jeffrey L.

“…Purpose In vivo imaging of programmed death ligand 1 (PD-L1) during immunotherapy could potentially monitor changing PD-L1 expression and PD-L1 expression…”
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Intramolecular Thioether Crosslinking of Therapeutic Proteins to Increase Proteolytic Stability by Lindgren, Joel, Eriksson Karlström, Amelie

“…Protein‐based pharmaceuticals typically display high selectivity and low toxicity, but are also characterized by low oral availability, mainly because of…”
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Specific Binding of Cu(II) Ions to Amyloid-Beta Peptides Bound to Aggregation-Inhibiting Molecules or SDS Micelles Creates Complexes that Generate Radical Oxygen Species by Tiiman, Ann, Luo, Jinghui, Wallin, Cecilia, Olsson, Lisa, Lindgren, Joel, Jarvet, Jϋri, Per, Roos, Sholts, Sabrina B, Rahimipour, Shai, Abrahams, Jan Pieter, Karlström, Amelie Eriksson, Gräslund, Astrid, Wärmländer, Sebastian K T S

“…Aggregation of the amyloid-beta (Aβ) peptide into insoluble plaques is a major factor in Alzheimer's disease (AD) pathology. Another major factor in AD is…”
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A Native Chemical Ligation Approach for Combinatorial Assembly of Affibody Molecules by Lindgren, Joel, Ekblad, Caroline, Abrahmsén, Lars, Eriksson Karlström, Amelie

“…Affinity molecules labeled with different reporter groups, such as fluorophores or radionuclides, are valuable research tools used in a variety of…”
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A GLP-1 receptor agonist conjugated to an albumin-binding domain for extended half-life by Lindgren, Joel, Refai, Essam, Zaitsev, Sergei V., Abrahmsén, Lars, Berggren, Per-Olof, Karlström, Amelie Eriksson

“…ABSTRACT Glucagon‐like peptide 1 (GLP‐1) and related peptide agonists have been extensively investigated for glycaemic control in Type 2 diabetes, and may also…”
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Engineered non-fluorescent Affibody molecules facilitate studies of the amyloid-beta (Aβ) peptide in monomeric form: Low pH was found to reduce Aβ/Cu(II) binding affinity by Lindgren, Joel, Segerfeldt, Patrik, Sholts, Sabrina B., Gräslund, Astrid, Karlström, Amelie Eriksson, Wärmländer, Sebastian K.T.S.

“…Aggregation of amyloid-beta (Aβ) peptides into oligomers and amyloid plaques in the human brain is considered a causative factor in Alzheimer's disease (AD)…”
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N‐terminal engineering of amyloid‐β‐binding Affibody molecules yields improved chemical synthesis and higher binding affinity by Lindgren, Joel, Wahlström, Anna, Danielsson, Jens, Markova, Natalia, Ekblad, Caroline, Gräslund, Astrid, Abrahmsén, Lars, Karlström, Amelie Eriksson, Wärmländer, Sebastian K.T.S.

“…The aggregation of amyloid‐β (Aβ) peptides is believed to be a major factor in the onset and progression of Alzheimer's disease. Molecules binding with high…”
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N-terminal engineering of amyloid-[beta]-binding Affibody molecules yields improved chemical synthesis and higher binding affinity by Lindgren, Joel, Wahlstrom, Anna, Danielsson, Jens, Markova, Natalia, Ekblad, Caroline, Graslund, Astrid, Abrahmsen, Lars, Karlstrom, Amelie Eriksson, Warmlander, Sebastian KTS

“…The aggregation of amyloid-[beta] (A[beta]) peptides is believed to be a major factor in the onset and progression of Alzheimer's disease. Molecules binding…”
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