Search Results - "Lindgren, Anders E.G."

Modulation of Curli Assembly and Pellicle Biofilm Formation by Chemical and Protein Chaperones by Andersson, Emma K., Bengtsson, Christoffer, Evans, Margery L., Chorell, Erik, Sellstedt, Magnus, Lindgren, Anders E.G., Hufnagel, David A., Bhattacharya, Moumita, Tessier, Peter M., Wittung-Stafshede, Pernilla, Almqvist, Fredrik, Chapman, Matthew R.

“…Enteric bacteria assemble functional amyloid fibers, curli, on their surfaces that share structural and biochemical properties with disease-associated…”
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Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis by Flentie, Kelly, Harrison, Gregory A., Tükenmez, Hasan, Livny, Jonathan, Good, James A. D., Sarkar, Souvik, Zhu, Dennis X., Kinsella, Rachel L., Weiss, Leslie A., Solomon, Samantha D., Schene, Miranda E., Hansen, Mette R., Cairns, Andrew G., Kulén, Martina, Wixe, Torbjörn, Lindgren, Anders E. G., Chorell, Erik, Bengtsson, Christoffer, Krishnan, K. Syam, Hultgren, Scott J., Larsson, Christer, Almqvist, Fredrik, Stallings, Christina L.

“…Mycobacterium tuberculosis (Mtb) killed more people in 2017 than any other single infectious agent. This dangerous pathogen is able to withstand stresses…”
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Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2‑Pyridone Polyheterocycles Binding to α‑Synuclein and Amyloid‑β Fibrils by Adolfsson, Dan E, Tyagi, Mohit, Singh, Pardeep, Deuschmann, Adrian, Ådén, Jörgen, Gharibyan, Anna L, Jayaweera, Sanduni Wasana, Lindgren, Anders E. G, Olofsson, Anders, Almqvist, Fredrik

“…A BF3·OEt2 catalyzed intramolecular Povarov reaction was used to synthesize 15 chromenopyridine fused thiazolino-2-pyridone peptidomimetics. The reaction works…”
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THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates by Reithuber, Elisabeth, Wixe, Torbjörn, Ludwig, Kevin C., Müller, Anna, Uvell, Hanna, Grein, Fabian, Lindgren, Anders E. G., Muschiol, Sandra, Nannapaneni, Priyanka, Eriksson, Anna, Schneider, Tanja, Normark, Staffan, Henriques-Normark, Birgitta, Almqvist, Fredrik, Mellroth, Peter

“…Emerging antibiotic resistance demands identification of novel antibacterial compound classes. A bacterial whole-cell screen based on pneumococcal…”
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Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics by Nye, Taylor M, Tükenmez, Hasan, Singh, Pardeep, Flores-Mireles, Ana L, Obernuefemann, Chloe L P, Pinkner, Jerome S, Sarkar, Souvik, Bonde, Mari, Lindgren, Anders E G, Dodson, Karen W, Johansson, Jörgen, Almqvist, Fredrik, Caparon, Michael G, Hultgren, Scott J

“…The alarming rise of multidrug-resistant Gram-positive bacteria has precipitated a healthcare crisis, necessitating the development of new antimicrobial…”
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Towards small molecule inhibitors of mono-ADP-ribosyltransferases by Ekblad, Torun, Lindgren, Anders E.G., Andersson, C. David, Caraballo, Rémi, Thorsell, Ann-Gerd, Karlberg, Tobias, Spjut, Sara, Linusson, Anna, Schüler, Herwig, Elofsson, Mikael

“…Protein ADP-ribosylation is a post-translational modification involved in DNA repair, protein degradation, transcription regulation, and epigenetic events…”
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N-Acylated Derivatives of Sulfamethoxazole and Sulfafurazole Inhibit Intracellular Growth of Chlamydia trachomatis by MARWAHA, Sania, UVELL, Hanna, SALIN, Olli, LINDGREN, Anders E. G, SILVER, Jim, ELOFSSON, Mikael, GYLFE, Asa

“…Antibacterial compounds with novel modes of action are needed for management of bacterial infections. Here we describe a high-content screen of 9,800 compounds…”
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The Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism by Reithuber, Elisabeth, Nannapaneni, Priyanka, Rzhepishevska, Olena, Lindgren, Anders E G, Ilchenko, Oleksandr, Normark, Staffan, Almqvist, Fredrik, Henriques-Normark, Birgitta, Mellroth, Peter

“…, a major cause of pneumonia, sepsis, and meningitis worldwide, has the nasopharynges of small children as its main ecological niche. Depletion of pneumococci…”
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Design, synthesis and evaluation of triazole functionalized ring-fused 2-pyridones as antibacterial agents by Bengtsson, Christoffer, Lindgren, Anders E.G., Uvell, Hanna, Almqvist, Fredrik

“…Antibacterial resistance is today a worldwide problem and the demand for new classes of antibacterial agents with new mode of action is enormous. In the strive…”
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PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3 by Lindgren, Anders E. G, Karlberg, Tobias, Thorsell, Ann-Gerd, Hesse, Mareike, Spjut, Sara, Ekblad, Torun, Andersson, C. David, Pinto, Ana Filipa, Weigelt, Johan, Hottiger, Michael O, Linusson, Anna, Elofsson, Mikael, Schüler, Herwig

“…Inhibiting ADP-ribosyl transferases with PARP-inhibitors is considered a promising strategy for the treatment of many cancers and ischemia, but most of the…”
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Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening by Andersson, C. David, Karlberg, Tobias, Ekblad, Torun, Lindgren, Anders E. G, Thorsell, Ann-Gerd, Spjut, Sara, Uciechowska, Urszula, Niemiec, Moritz S, Wittung-Stafshede, Pernilla, Weigelt, Johan, Elofsson, Mikael, Schüler, Herwig, Linusson, Anna

“…The diphtheria toxin-like ADP-ribosyltransferases (ARTDs) are an enzyme family that catalyzes the transfer of ADP-ribose units onto substrate proteins by using…”
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Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors by Kulén, Martina, Núñez-Otero, Carlos, Cairns, Andrew G, Silver, Jim, Lindgren, Anders E G, Wede, Emma, Singh, Pardeep, Vielfort, Katarina, Bahnan, Wael, Good, James A D, Svensson, Richard, Bergström, Sven, Gylfe, Åsa, Almqvist, Fredrik

“…infections are a global health problem and new approaches to treat with drugs of high specificity would be valuable. A library of substituted ring fused…”
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Statistical molecular design: a tool to follow up hits from small-molecule screening by Lindgren, Anders E G, Larsson, Andreas, Linusson, Anna, Elofsson, Mikael

“…In high-throughput screening (HTS) a robust assay is used to interrogate a large collection of small organic molecules in order to find compounds, hits, with a…”
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Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3 by Lindgren, Anders E. G, Karlberg, Tobias, Ekblad, Torun, Spjut, Sara, Thorsell, Ann-Gerd, Andersson, C. David, Nhan, Ton Tong, Hellsten, Victor, Weigelt, Johan, Linusson, Anna, Schüler, Herwig, Elofsson, Mikael

“…The racemic 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[1-(pyridin-2-yl)­ethyl]­propanamide, 1, has previously been identified as a potent but unselective…”
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