Search Results - "Lindenmaier, Heike"
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Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein
Published in Biochemical pharmacology (15-05-2007)“…Human immunodeficiency virus 1 (HIV-1) infections are treated with HIV-protease inhibitors (PIs), nucleoside (NRTIs), non-nucleoside (NNRTIs), and nucleotide…”
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Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by Nucleoside, Nucleotide, and Non-Nucleoside Reverse Transcriptase Inhibitors
Published in Drug metabolism and disposition (01-03-2007)“…Many drug interactions with drugs used for the therapy of human immunodeficiency virus (HIV) occur at the level of different cytochrome P450 isozymes…”
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Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells
Published in Molecular pharmacology (01-11-2004)“…The drug transporter P-glycoprotein (ABCB1) plays an important role in drug distribution and elimination, and when overexpressed it may confer multidrug…”
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Interaction of antiepileptic drugs with human P-glycoprotein in vitro
Published in The Journal of pharmacology and experimental therapeutics (01-10-2003)“…About one-third of epilepsy patients are resistant to treatment with antiepileptic drugs (AEDs). This refractoriness is not fully understood, but is thought to…”
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INTERACTION OF PROGESTINS WITH THE HUMAN MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2 (MRP2)
Published in Drug metabolism and disposition (01-11-2005)“…Progestins are widely used as oral contraceptives and hormone replacement therapy. Recently it has been demonstrated that many progestins are inhibitors of…”
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Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine
Published in Biochemical and biophysical research communications (16-07-2004)“…Caffeine (1,3,7-trimethylxanthine) is daily and widely consumed in beverages and food and is mainly metabolized to 1,7-dimethylxanthine and 1-methylxanthine…”
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EGFR, KRAS, BRAF and ALK gene alterations in lung adenocarcinomas: patient outcome, interplay with morphology and immunophenotype
Published in The European respiratory journal (01-03-2014)“…Numerous studies have been published on single aspects of pulmonary adenocarcinoma (ADC). To comprehensively link clinically relevant ADC characteristics, we…”
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Interaction of the mitotic kinesin Eg5 inhibitor monastrol with P-glycoprotein
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-01-2006)“…Monastrol is the first characterised small molecule inhibitor of the motor protein Eg5 involved in bipolar mitotic spindle assembly. Eg5 localises to…”
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Influence of lipid lowering fibrates on P-glycoprotein activity in vitro
Published in Biochemical pharmacology (15-01-2004)“…Statin/fibrate combinations are frequently used to treat mixed dyslipidemia. However, these combinations may cause life-threatening drug interactions (e.g…”
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Dose individualisation in patients with renal insufficiency: does drug labelling support optimal management?
Published in European journal of clinical pharmacology (2005)“…An important information source for pharmacotherapy in populations at risk is drug labelling. We compared the recommendations for patients with renal…”
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Telomere erosion varies during in vitro aging of normal human fibroblasts from young and adult donors
Published in Cancer research (Chicago, Ill.) (01-06-2000)“…The life span of normal fibroblasts in vitro (Hayflick limit) depends on donor age, and telomere shortening has been proposed as a potential mechanism. By…”
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