Search Results - "Lindenau, Kristen"
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Reciprocal regulation of chaperone-mediated autophagy and the circadian clock
Published in Nature cell biology (01-12-2021)“…Circadian rhythms align physiological functions with the light–dark cycle through oscillatory changes in the abundance of proteins in the clock transcriptional…”
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Direct evidence of bradycardic effect of omega-3 fatty acids acting on nucleus ambiguus
Published in Neuroscience letters (14-09-2020)“…•Omega 3 fatty acids reduce heart rate via unclear mechanisms.•Docosahexaenoic acid (DHA) increases cytosolic Ca2+and depolarizes nucleus…”
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Blood-Brain Barrier Disruption Mediated by FFA1 Receptor-Evidence Using Miniscope
Published in International journal of molecular sciences (18-02-2022)“…Omega-3 polyunsaturated fatty acids (n-3 PUFAs), obtained from diet and dietary supplements, have been tested in clinical trials for the prevention or…”
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GPR55-mediated effects on brain microvascular endothelial cells and the blood–brain barrier
Published in Neuroscience (21-08-2019)“…GPR55, an atypical cannabinoid receptor activated by lysophosphatidylinositol (LPI) has been involved in various physiological and pathological processes. We…”
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Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy
Published in Cell reports (Cambridge) (26-12-2023)“…Chaperone-mediated autophagy (CMA) and endosomal microautophagy (eMI) are pathways for selective degradation of cytosolic proteins in lysosomes and late…”
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Restoration of LAMP2A expression in old mice leads to changes in the T cell compartment that support improved immune function
Published in Proceedings of the National Academy of Sciences - PNAS (17-09-2024)“…Chaperone-mediated autophagy (CMA) is a selective form of autophagy that contributes to the maintenance of cellular homeostasis. CMA activity declines with age…”
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Calorie restriction and calorie-restriction mimetics activate chaperone-mediated autophagy
Published in Proceedings of the National Academy of Sciences - PNAS (25-06-2024)“…Chaperone-mediated autophagy (CMA) is part of the mammalian cellular proteostasis network that ensures protein quality control, maintenance of proteome…”
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Chaperone-mediated autophagy regulates adipocyte differentiation
Published in Science advances (16-11-2022)“…Adipogenesis is a tightly orchestrated multistep process wherein preadipocytes differentiate into adipocytes. The most studied aspect of adipogenesis is its…”
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Abstract 2091: Pharmacological inhibition of chaperone-mediated autophagy via NCoR1/RARα targeting is effective against non-small cell lung cancer
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Dysregulation of autophagy, the lysosomal degradation of intracellular components, has been universally described in cancer. While activity of…”
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