Search Results - "Linden, David J."

Visualization of NMDA receptor–dependent AMPA receptor synaptic plasticity in vivo by Zhang, Yong, Cudmore, Robert H, Lin, Da-Ting, Linden, David J, Huganir, Richard L

“…Insertion of AMPA receptors into the synaptic membrane is thought to be a central mechanism for controlling experience-dependent changes in synaptic strength,…”
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Reevaluating the Role of LTD in Cerebellar Motor Learning by Schonewille, Martijn, Gao, Zhenyu, Boele, Henk-Jan, Vinueza Veloz, Maria F., Amerika, Wardell E., Šimek, Antonia A.M., De Jeu, Marcel T., Steinberg, Jordan P., Takamiya, Kogo, Hoebeek, Freek E., Linden, David J., Huganir, Richard L., De Zeeuw, Chris I.

“…Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be required for cerebellar motor learning. To date, tests of…”
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Real-time self-regulation of emotion networks in patients with depression by Linden, David E J, Habes, Isabelle, Johnston, Stephen J, Linden, Stefanie, Tatineni, Ranjit, Subramanian, Leena, Sorger, Bettina, Healy, David, Goebel, Rainer

“…Many patients show no or incomplete responses to current pharmacological or psychological therapies for depression. Here we explored the feasibility of a new…”
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Increased fractional anisotropy in the motor tracts of Parkinson's disease suggests compensatory neuroplasticity or selective neurodegeneration by Mole, Jilu Princy, Subramanian, Leena, Bracht, Tobias, Morris, Huw, Metzler-Baddeley, Claudia, Linden, David E. J.

“…Objective To determine the differences in motor pathways and selected non-motor pathways of the basal ganglia in Parkinson’s disease (PD) patients compared to…”
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Phenotypic Manifestation of Genetic Risk for Schizophrenia During Adolescence in the General Population by Jones, Hannah J, Stergiakouli, Evie, Tansey, Katherine E, Hubbard, Leon, Heron, Jon, Cannon, Mary, Holmans, Peter, Lewis, Glyn, Linden, David E J, Jones, Peter B, Davey Smith, George, O'Donovan, Michael C, Owen, Michael J, Walters, James T, Zammit, Stanley

“…Schizophrenia is a highly heritable, polygenic condition characterized by a relatively diverse phenotype and frequent comorbid conditions, such as anxiety and…”
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STIM1 Regulates Somatic Ca2+ Signals and Intrinsic Firing Properties of Cerebellar Purkinje Neurons by Ryu, Changhyeon, Jang, Dong Cheol, Jung, Dayoon, Kim, Yong Gyu, Shim, Hyun Geun, Ryu, Hyun-Hee, Lee, Yong-Seok, Linden, David J, Worley, Paul F, Kim, Sang Jeong

“…Control of Ca2+ flux between the cytosol and intracellular Ca2+ stores is essential for maintaining normal cellular function. It has been well established in…”
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The default mode network and the working memory network are not anti-correlated during all phases of a working memory task by Piccoli, Tommaso, Valente, Giancarlo, Linden, David E J, Re, Marta, Esposito, Fabrizio, Sack, Alexander T, Di Salle, Francesco

“…The default mode network and the working memory network are known to be anti-correlated during sustained cognitive processing, in a load-dependent manner. We…”
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Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury by Jin, Yunju, Dougherty, Sarah E., Wood, Kevin, Sun, Landy, Cudmore, Robert H., Abdalla, Aya, Kannan, Geetha, Pletnikov, Mikhail, Hashemi, Parastoo, Linden, David J.

“…It is widely believed that damaged axons in the adult mammalian brain have little capacity to regrow, thereby impeding functional recovery after injury…”
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The other side of the engram: experience-driven changes in neuronal intrinsic excitability by Linden, David J, Zhang, Wei

“…Modern theories of memory storage have largely focused on persistent, experience-dependent changes in synaptic function such as long-term potentiation and…”
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Dysfunctional Long-Range Coordination of Neural Activity during Gestalt Perception in Schizophrenia by Uhlhaas, Peter J, Linden, David E. J, Singer, Wolf, Haenschel, Corinna, Lindner, Michael, Maurer, Konrad, Rodriguez, Eugenio

“…Recent theoretical and empirical research on schizophrenia converges on the notion that core aspects of the pathophysiology of the disorder may arise from a…”
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Cortical Oscillatory Activity Is Critical for Working Memory as Revealed by Deficits in Early-Onset Schizophrenia by Haenschel, Corinna, Bittner, Robert A, Waltz, James, Haertling, Fabian, Wibral, Michael, Singer, Wolf, Linden, David E. J, Rodriguez, Eugenio

“…Impairments in working memory (WM) are a core cognitive deficit in schizophrenia. Neurophysiological models suggest that deficits during WM maintenance in…”
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Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons by Chang, Michael C, Park, Joo Min, Pelkey, Kenneth A, Grabenstatter, Heidi L, Xu, Desheng, Linden, David J, Sutula, Thomas P, McBain, Chris J, Worley, Paul F

“…The authors report that the immediate-early gene Narp accumulates at excitatory synapses on parvalbumin-expressing interneurons. Narp recruits AMPA receptors…”
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Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model by Das, Ishita, Park, Joo-Min, Shin, Jung H, Jeon, Soo Kyeong, Lorenzi, Hernan, Linden, David J, Worley, Paul F, Reeves, Roger H

“…Down syndrome (DS) is among the most frequent genetic causes of intellectual disability, and ameliorating this deficit is a major goal in support of people…”
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Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation by Zhang, Wenchi, Chuang, Yang-An, Na, Youn, Ye, Zengyou, Yang, Liuqing, Lin, Raozhou, Zhou, Jiechao, Wu, Jing, Qiu, Jessica, Savonenko, Alena, Leahy, Daniel J., Huganir, Richard, Linden, David J., Worley, Paul F.

“…Arc is a synaptic protein essential for memory consolidation. Recent studies indicate that Arc originates in evolution from a Ty3-Gypsy retrotransposon GAG…”
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Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD by Park, Sungjin, Park, Joo Min, Kim, Sangmok, Kim, Jin-Ah, Shepherd, Jason D., Smith-Hicks, Constance L., Chowdhury, Shoaib, Kaufmann, Walter, Kuhl, Dietmar, Ryazanov, Alexey G., Huganir, Richard L., Linden, David J., Worley, Paul F.

“…Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is…”
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Localizing P300 Generators in Visual Target and Distractor Processing: A Combined Event-Related Potential and Functional Magnetic Resonance Imaging Study by Bledowski, Christoph, Prvulovic, David, Hoechstetter, Karsten, Scherg, Michael, Wibral, Michael, Goebel, Rainer, Linden, David E. J

“…Constraints from functional magnetic resonance imaging (fMRI) were used to identify the sources of the visual P300 event-related potential (ERP). Healthy…”
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Homeostatic Scaling Requires Group I mGluR Activation Mediated by Homer1a by Hu, Jia-Hua, Park, Joo Min, Park, Sungjin, Xiao, Bo, Dehoff, Marlin H., Kim, Sangmok, Hayashi, Takashi, Schwarz, Martin K., Huganir, Richard L., Seeburg, Peter H., Linden, David J., Worley, Paul F.

“…Homeostatic scaling is a non-Hebbian form of neural plasticity that maintains neuronal excitability and informational content of synaptic arrays in the face of…”
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Angry expressions strengthen the encoding and maintenance of face identity representations in visual working memory by Jackson, Margaret C., Linden, David E. J., Raymond, Jane E.

“…Visual working memory (WM) for face identities is enhanced when faces express negative versus positive emotion. To determine the stage at which emotion exerts…”
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DHHC8-dependent PICK1 palmitoylation is required for induction of cerebellar long-term synaptic depression by Thomas, Gareth M, Hayashi, Takashi, Huganir, Richard L, Linden, David J

“…The palmitoyl acyltransferase (PAT) DHHC8 is implicated in synaptic regulation but few DHHC8 substrates are known. Here we report that DHHC8 binds and…”
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Long-Term Depression at the Mossy Fiber-Deep Cerebellar Nucleus Synapse by Zhang, Wei, Linden, David J

“…Several lines of evidence have indicated that the deep cerebellar nuclei (DCN) are a site of memory storage for certain forms of motor learning, most notably…”
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