Search Results - "Lindemann, Charles B."

Functional anatomy of the mammalian sperm flagellum by Lindemann, Charles B., Lesich, Kathleen A.

“…The eukaryotic flagellum is the organelle responsible for the propulsion of the male gamete in most animals. Without exception, sperm of all mammalian species…”
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Flagellar and ciliary beating: the proven and the possible by Lindemann, Charles B, Lesich, Kathleen A

“…The working mechanism of the eukaryotic flagellar axoneme remains one of nature's most enduring puzzles. The basic mechanical operation of the axoneme is now a…”
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The many modes of flagellar and ciliary beating: Insights from a physical analysis by Lindemann, Charles B., Lesich, Kathleen A.

“…The mechanism that allows the axoneme of eukaryotic cilia and flagella to produce both helical and planar beating is an enduring puzzle. The nine outer…”
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Engaging the “Clutch” to Move Forward by Lindemann, Charles B.

“…It is 20 years since the publication of the geometric clutch (GC) hypothesis as a mechanistic explanation of ciliary and flagellar beating (1). It was an idea…”
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Dynein Regulation: Going into Circles Can Set Things Straight by Lindemann, Charles B.

“…It has long been known that eukaryotic cilia and flagella are autonomous oscillators capable of generating a beat cycle independent of regulation by the parent…”
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The geometric clutch at 20: stripping gears or gaining traction? by Lindemann, Charles B, Lesich, Kathleen A

“…It has been 20 years since the geometric clutch (GC) hypothesis was first proposed. The core principle of the GC mechanism is fairly simple. When the axoneme…”
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The Geometric Clutch as a Working Hypothesis for Future Research on Cilia and Flagella by LINDEMANN, CHARLES B.

“…:  The Geometric Clutch hypothesis contends that the forces transverse to the flagellar axis (t‐forces) act on the axonemal scaffold to regulate flagellar…”
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The flagellar germ‐line hypothesis: How flagellate and ciliate gametes significantly shaped the evolution of organismal complexity by Lindemann, Charles B.

“…This essay presents a hypothesis which contends that the development of organismic complexity in the eukaryotes depended extensively on propagation via…”
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The physiological role of ADP and Mg2+ in maintaining a stable beat cycle in bull sperm by Lindemann, Charles B., dePinho, Tania G., Lesich, Kathleen A.

“…Sperm flagella derive their motive power from the motor protein dynein. In this study, we show that maintenance of the flagellar beat cycle in…”
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Structural-Functional Relationships of the Dynein, Spokes, and Central-Pair Projections Predicted from an Analysis of the Forces Acting within a Flagellum by Lindemann, Charles B.

“…In the axoneme of eukaryotic flagella the dynein motor proteins form crossbridges between the outer doublet microtubules. These motor proteins generate force…”
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The effects of Ca2+ and ADP on dynein switching during the beat cycle of reactivated bull sperm models by Lesich, Kathleen A., dePinho, Tania G., Dionne, Benjamin J., Lindemann, Charles B.

“…Calcium regulation of flagellar motility is the basis for chemotaxis, phototaxis, and hyperactivation responses in eukaryotic flagellates and spermatozoa. Ca2+…”
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The mechanics of cilia and flagella: What we know and what we need to know by Lindemann, Charles B., Lesich, Kathleen A.

“…In this review, we provide a condensed overview of what is currently known about the mechanical functioning of the flagellar/ciliary axoneme. We also present a…”
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Testing the Geometric Clutch hypothesis by Lindemann, Charles B.

“…The Geometric Clutch hypothesis is based on the premise that transverse forces (t-forces) acting on the outer doublets of the eukaryotic axoneme coordinate the…”
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Heart of the Beat (the Flagellar Beat, that Is) by Lindemann, Charles B.

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Measurement of the Force Produced by an Intact Bull Sperm Flagellum in Isometric Arrest and Estimation of the Dynein Stall Force by Schmitz, Kathleen A., Holcomb-Wygle, Dana L., Oberski, Danial J., Lindemann, Charles B.

“…The force generated by a detergent-extracted reactivated bull sperm flagellum during an isometric stall was measured with a force-calibrated glass microprobe…”
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Ultrastructural evidence that motility changes caused by variations in ATP, Mg2+, and ADP correlate to conformational changes in reactivated bull sperm axonemes by Lesich, Kathleen A., de Pinho, Tania G., Dang, Loan, Lindemann, Charles B.

“…We report the results of an ultrastructural study of Triton X‐100‐extracted, Mg‐adenosine triphosphate (ATP)‐reactivated bull sperm. We utilized a rapid…”
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Mechanics of the eukaryotic flagellar axoneme: Evidence for structural distortion during bending by Lesich, Kathleen A., dePinho, Tania G., Pelle, Dominic W., Lindemann, Charles B.

“…The sliding doublet mechanism is the established explanation that allows us to understand the process of ciliary and flagellar bending. In this study, we apply…”
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The Calcium Response of Mouse Sperm Flagella: Role of Calcium Ions in the Regulation of Dynein Activity by LESICH, Kathleen A, KELSCH, Courtney B, PONICHTER, Kristen L, DIONNE, Benjamin J, DANG, Loan, LINDEMANN, Charles B

“…Triton X-100-extracted mouse sperm treated with 0.1 mM ATP and 1.0 mM Ca(2+) exhibit an extremely coiled configuration that has been previously described as a…”
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Insights into the Mechanism of ADP Action on Flagellar Motility Derived from Studies on Bull Sperm by Lesich, Kathleen A., Pelle, Dominic W., Lindemann, Charles B.

“…Adenosine diphosphate (ADP) is known to have interesting effects on flagellar motility. Permeabilized and reactivated bull sperm exhibit a marked reduction in…”
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Experimental Evidence for the Geometric Clutch Hypothesis by Lindemann, Charles B.

“…The cilia and flagella of eukaryotic cells are complex filamentous organelles that undulate rapidly and produce propulsive force against the fluids that…”
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