Search Results - "Lindblom, R"

Metabolomic Profiling Reveals a Role for Caspase-2 in Lipoapoptosis by Johnson, Erika Segear, Lindblom, Kelly R., Robeson, Alexander, Stevens, Robert D., Ilkayeva, Olga R., Newgard, Christopher B., Kornbluth, Sally, Andersen, Joshua L.

“…The accumulation of long-chain fatty acids (LCFAs) in non-adipose tissues results in lipid-induced cytotoxicity (or lipoapoptosis). Lipoapoptosis has been…”
Get full text

Hygienic interventions to decrease deep sternal wound infections following coronary artery bypass grafting by Lytsy, B, Lindblom, R.P.F, Ransjö, U, Leo-Swenne, C

“…Summary Background The department of Cardiothoracic Surgery at Uppsala University Hospital has 25 beds in one to four patient rooms and an operating suite…”
Get full text

A Biotin Switch-Based Proteomics Approach Identifies 14-3-3ζ as a Target of Sirt1 in the Metabolic Regulation of Caspase-2 by Andersen, Joshua L., Thompson, J. Will, Lindblom, Kelly R., Johnson, Erika S., Yang, Chih-Sheng, Lilley, Lauren R., Freel, Christopher D., Moseley, M. Arthur, Kornbluth, Sally

“…While lysine acetylation in the nucleus is well characterized, comparatively little is known about its significance in cytoplasmic signaling. Here we show that…”
Get full text

Dimer‐specific immunoprecipitation of active caspase‐2 identifies TRAF proteins as novel activators by Robeson, Alexander C, Lindblom, Kelly R, Wojton, Jeffrey, Kornbluth, Sally, Matsuura, Kenkyo

“…Caspase‐2 has been shown to initiate apoptotic cell death in response to specific intracellular stressors such as DNA damage. However, the molecular mechanisms…”
Get full text

An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials by Tse, Edwin G, Aithani, Laksh, Anderson, Mark, Cardoso-Silva, Jonathan, Cincilla, Giovanni, Conduit, Gareth J, Galushka, Mykola, Guan, Davy, Hallyburton, Irene, Irwin, Benedict W. J, Kirk, Kiaran, Lehane, Adele M, Lindblom, Julia C. R, Lui, Raymond, Matthews, Slade, McCulloch, James, Motion, Alice, Ng, Ho Leung, Öeren, Mario, Robertson, Murray N, Spadavecchio, Vito, Tatsis, Vasileios A, van Hoorn, Willem P, Wade, Alexander D, Whitehead, Thomas M, Willis, Paul, Todd, Matthew H

“…The Open Source Malaria (OSM) consortium is developing compounds that kill the human malaria parasite, Plasmodium falciparum, by targeting PfATP4, an essential…”
Get full text

Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis by Machado, M V, Michelotti, G A, Pereira, T de Almeida, Boursier, J, Kruger, L, Swiderska-Syn, M, Karaca, G, Xie, G, Guy, C D, Bohinc, B, Lindblom, K R, Johnson, E, Kornbluth, S, Diehl, A M

“…Caspase-2 is an initiator caspase involved in multiple apoptotic pathways, particularly in response to specific intracellular stressors (eg, DNA damage, ER…”
Get more information

Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist by Zheng, Yajun, Zhuang, Linghang, Fan, Kristi Yi, Tice, Colin M, Zhao, Wei, Dong, Chengguo, Lotesta, Stephen D, Leftheris, Katerina, Lindblom, Peter R, Liu, Zhijie, Shimada, Jun, Noto, Paul B, Meng, Shi, Hardy, Andrew, Howard, Lamont, Krosky, Paula, Guo, Joan, Lipinski, Kerri, Kandpal, Geeta, Bukhtiyarov, Yuri, Zhao, Yi, Lala, Deepak, Van Orden, Rebecca, Zhou, Jing, Chen, Guozhou, Wu, Zhongren, McKeever, Brian M, McGeehan, Gerard M, Gregg, Richard E, Claremon, David A, Singh, Suresh B

“…This article describes the application of Contour to the design and discovery of a novel, potent, orally efficacious liver X receptor β (LXRβ) agonist (17)…”
Get full text

An electronic environment and contact direction sensitive scoring function for predicting affinities of protein–ligand complexes in Contour by Lindblom, Peter R., Wu, Guosheng, Liu, Zhijie, Jim, Kam-Chuen, Baldwin, John J., Gregg, Richard E., Claremon, David A., Singh, Suresh B.

“…•Contour® grows drug-like molecules in protein binding site.•Atomic model comprises hybridization and polarization state.•Score captures electrostatic…”
Get full text

Resistant starch ameliorates heat treated diet-induced gut permeability and renal dysfunction in experimental diabetes by Snelson, M, Tan, S.M, Sourris, K.C, Higgins, G.C, Ding, Y, Lindblom, R, Nguyen, T.V, Thallas-Bonke, V, Cooper, M.E, Coughlan, M.T

Get full text

A pH Fingerprint Assay to Identify Inhibitors of Multiple Validated and Potential Antimalarial Drug Targets by Lindblom, Julia C. R., Zhang, Xinxin, Lehane, Adele M.

“…New drugs with novel modes of action are needed to safeguard malaria treatment. In recent years, millions of compounds have been tested for their ability to…”
Get full text

Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1 by Tice, Colin M., Zhao, Wei, Krosky, Paula M., Kruk, Barbara A., Berbaum, Jennifer, Johnson, Judith A., Bukhtiyarov, Yuri, Panemangalore, Reshma, Scott, Boyd B., Zhao, Yi, Bruno, Joseph G., Howard, Lamont, Togias, Jennifer, Ye, Yuan-Jie, Singh, Suresh B., McKeever, Brian M., Lindblom, Peter R., Guo, Joan, Guo, Rong, Nar, Herbert, Schuler-Metz, Annette, Gregg, Richard E., Leftheris, Katerina, Harrison, Richard K., McGeehan, Gerard M., Zhuang, Linghang, Claremon, David A.

“…Synthesis of 2-adamantyl carbamate derivatives of piperidines and pyrrolidines led to the discovery of 9a with an IC50 of 15.2nM against human 11β-HSD1 in…”
Get full text

Strain influences on inflammatory pathway activation, cell infiltration and complement cascade after traumatic brain injury in the rat by Al Nimer, Faiez, Lindblom, Rickard, Ström, Mikael, Guerreiro-Cacais, André Ortlieb, Parsa, Roham, Aeinehband, Shahin, Mathiesen, Tiit, Lidman, Olle, Piehl, Fredrik

“…Highlight ► Genetic heterogeneity influences the inflammatory response and neurodegeneration in traumatic brain injury…”
Get full text

Naturally occurring variation in the Glutathione-S-Transferase 4 gene determines neurodegeneration after traumatic brain injury by Al Nimer, Faiez, Ström, Mikael, Lindblom, Rickard, Aeinehband, Shahin, Bellander, Bo-Michael, Nyengaard, Jens R, Lidman, Olle, Piehl, Fredrik

“…Genetic factors are important for outcome after traumatic brain injury (TBI), although exact knowledge of relevant genes/pathways is still lacking. We here…”
Get more information

Both MHC and non-MHC genes regulate inflammation and T-cell response after traumatic brain injury by Al Nimer, Faiez, Beyeen, Amennai Daniel, Lindblom, Rickard, Ström, Mikael, Aeinehband, Shahin, Lidman, Olle, Piehl, Fredrik

“…Research highlights ► The Ciita haplotype regulates expression of MHC at the mRNA level after TBI. ► MHC genes regulate expression of MHC at the protein level…”
Get full text

eReply. Aneurysm of the internal mammary artery may imitate a mediastinal mass by Lindblom, Rickard P.F.

Get full text

Naturally Occurring Genetic Variability in Expression of Gsta4 is Associated with Differential Survival of Axotomized Rat Motoneurons by Ström, Mikael, Al Nimer, Faiez, Lindblom, Rickard, Nyengaard, Jens Randel, Piehl, Fredrik

“…A large number of molecular pathways have been implicated in the degeneration of axotomized motoneurons. We previously have demonstrated substantial…”
Get full text

Identification of gene regions regulating inflammatory microglial response in the rat CNS after nerve injury by Diez, Margarita, Abdelmagid, Nada, Harnesk, Karin, Ström, Mikael, Lidman, Olle, Swanberg, Maria, Lindblom, Rickard, Al-Nimer, Faiez, Jagodic, Maja, Olsson, Tomas, Piehl, Fredrik

“…Abstract Local CNS inflammation takes place in many neurological disorders and is important for autoimmune neuroinflammation. Microglial activation is…”
Get full text

Genetic influence on expression of complement system components after nerve injury by Lindblom, R, Piehl, F, Diez, M

Get full text

GSTA4, A CANDIDATE GENE FOR REGULATION OF NERVE INJURY-INDUCED NEURODEGENERATION IN THE RAT by Al Nimer, F, Strom, M, Lindblom, R, Piehl, F

Get full text

Neuinflam9/Toxo1 regulates the innate immune response after nerve injury and susceptibility to autoimmune neuroinflammation in rat by Abdelmagid, N, Al Nimer, F, Ockinger, J, Lindblom, R, Zhang, XM, Bedri, SK, Saoudi, A, Fournie, G, Olsson, T, Jagodic, M, Piehl, F, Diez, M

Get full text