Search Results - "Lindahl, Ulf"

Specificity of glycosaminoglycan–protein interactions by Kjellén, Lena, Lindahl, Ulf

“…[Display omitted] •Binding of proteins to glycosaminoglycans regulates development and homeostasis.•Saccharide charge distribution, dynamics and conformation…”
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Heparan sulfate-protein interactions--a concept for drug design? by Lindahl, Ulf

“…The glycosaminoglycan, heparan sulfate (HS) is composed of alternating units of hexuronic acid and glucosamine, that are variously sulfate-substituted at…”
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A personal voyage through the proteoglycan field by Lindahl, Ulf

“…The concept of “proteoglycans” as discrete molecules surfaced some 40years ago, out of previously muddled notions of the extracellular matrix. Core proteins…”
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Chapter 3 Interactions Between Heparan Sulfate and Proteins—Design and Functional Implications by Lindahl, Ulf, Li, Jin‐ping

“…Heparan sulfate (HS) proteoglycans at cell surfaces and in the extracellular matrix of most animal tissues are essential in development and homeostasis, and…”
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Interactions between heparan sulfate and proteins: the concept of specificity by Kreuger, Johan, Spillmann, Dorothe, Li, Jin-ping, Lindahl, Ulf

“…Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions with growth factors, morphogens, and receptors. Thus, PGs modulate…”
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Heparan Sulfate Domain Organization and Sulfation Modulate FGF-induced Cell Signaling by Jastrebova, Nadja, Vanwildemeersch, Maarten, Lindahl, Ulf, Spillmann, Dorothe

“…Heparan sulfates (HSs) modulate various developmental and homeostatic processes by binding to protein ligands. We have evaluated the structural characteristics…”
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Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response by O'Callaghan, Paul, Li, Jin-Ping, Lannfelt, Lars, Lindahl, Ulf, Zhang, Xiao

“…Microglia rapidly mount an inflammatory response to pathogens in the central nervous system (CNS). Heparan sulfate proteoglycans (HSPGs) have been attributed…”
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Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases by Zcharia, Eyal, Jia, Juan, Zhang, Xiao, Baraz, Lea, Lindahl, Ulf, Peretz, Tamar, Vlodavsky, Israel, Li, Jin-Ping

“…Heparanase, a mammalian endo-beta-D-glucuronidase, specifically degrades heparan sulfate proteoglycans ubiquitously associated with the cell surface and…”
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QSulf1 Remodels the 6-O Sulfation States of Cell Surface Heparan Sulfate Proteoglycans to Promote Wnt Signaling by Ai, Xingbin, Do, Anh-Tri, Lozynska, Olga, Kusche-Gullberg, Marion, Lindahl, Ulf, Emerson, Charles P.

“…The 6-O sulfation states of cell surface heparan sulfate proteoglycans (HSPGs) are dynamically regulated to control the growth and specification of embryonic…”
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Surface-exposed Amino Acid Residues of HPV16 L1 Protein Mediating Interaction with Cell Surface Heparan Sulfate by Knappe, Maren, Bodevin, Sabrina, Selinka, Hans-Christoph, Spillmann, Dorothe, Streeck, Rolf E., Chen, Xiaojiang S., Lindahl, Ulf, Sapp, Martin

“…Efficient infection of cells by human papillomaviruses (HPVs) and pseudovirions requires primary interaction with cell surface proteoglycans with apparent…”
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Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer's disease by Zhang, Xiao, O'Callaghan, Paul, Li, Honglian, Tan, Yingxia, Zhang, Ganlin, Barash, Uri, Wang, Xiaomin, Lannfelt, Lars, Vlodavsky, Israel, Lindahl, Ulf, Li, Jin-Ping

“…Defective amyloid-β (Aβ) clearance from the brain is a major contributing factor to the pathophysiology of Alzheimer's disease (AD). Aβ clearance is mediated…”
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Substrate Specificity and Domain Functions of Extracellular Heparan Sulfate 6-O-Endosulfatases, QSulf1 and QSulf2 by Ai, Xingbin, Do, Anh-Tri, Kusche-Gullberg, Marion, Lindahl, Ulf, Lu, Ke, Emerson, Charles P.

“…The extracellular sulfatases (Sulfs) are an evolutionally conserved family of heparan sulfate (HS)-specific 6-O-endosulfatases. These enzymes remodel the…”
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Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior by Zcharia, Eyal, Metzger, Shula, Chajek‐Shaul, Tova, Aingorn, Helena, Elkin, Michael, Friedmann, Yael, Weinstein, Talia, Li, Jin‐Ping, Lindahl, Ulf, Vlodavsky, Israel

“…We have generated homozygous trans¬genic mice (hpa‐tg) overexpressing human hepara¬nase (endo‐β‐D‐glucuronidase) in all tissues and char¬acterized the…”
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Structure and biological interactions of heparin and heparan sulfate by Casu, Benito, Lindahl, Ulf

“…This chapter discusses the structural aspects and structure–activity relationships of heparin/heparan sulfate (HS). The molecular mechanism behind the…”
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Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate by Li, Jin-Ping, Escobar Galvis, Martha L, Jia, Juan, Zhang, Xiao, Jastrebova, Nadja, Spillmann, Dorothe, Gottfridsson, Eva, van Kuppevelt, Toin H, Zcharia, Eyal, Vlodavsky, Israel, Lindahl, Ulf

“…Heparan sulfate proteoglycans (HSPGs) interact with numerous proteins of importance in animal development and homeostasis. Heparanase, which is expressed in…”
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In vivo Fragmentation of Heparan Sulfate by Heparanase Overexpression Renders Mice Resistant to Amyloid Protein A Amyloidosis by Li, Jin-Ping, Martha L. Escobar Galvis, Gong, Feng, Zhang, Xiao, Zcharia, Eyal, Metzger, Shula, Vlodavsky, Israel, Kisilevsky, Robert, Lindahl, Ulf, Gajdusek, D. Carleton

“…Amyloid diseases encompass >20 medical disorders that include amyloid protein A (AA) amyloidosis, Alzheimer's disease, and type 2 diabetes. A common feature of…”
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Heparan Sulfate-related Oligosaccharides in Ternary Complex Formation with Fibroblast Growth Factors 1 and 2 and Their Receptors by Jastrebova, Nadja, Vanwildemeersch, Maarten, Rapraeger, Alan C., Giménez-Gallego, Guillermo, Lindahl, Ulf, Spillmann, Dorothe

“…Biosynthesis of heparan sulfate (HS) is strictly regulated to yield products with cell/tissue-specific composition. Interactions between HS and a variety of…”
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Sequence Analysis of Heparan Sulfate Epitopes with Graded Affinities for Fibroblast Growth Factors 1 and 2 by Kreuger, J, Salmivirta, M, Sturiale, L, Giménez-Gallego, G, Lindahl, U

“…Proteins that belong to the fibroblast growth factor (FGF) family regulate proliferation, migration, and differentiation of many cell types. Several FGFs,…”
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Defining the Interleukin-8-binding Domain of Heparan Sulfate by Spillmann, D, Witt, D, Lindahl, U

“…Interleukin-8, a member of the C X C chemokine family, has been shown to bind to glycosaminoglycans. It has been suggested that heparan sulfate on cell…”
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The Putative Tumor Suppressors EXT1 and EXT2 Are Glycosyltransferases Required for the Biosynthesis of Heparan Sulfate by Lind, Thomas, Tufaro, Frank, McCormick, Craig, Lindahl, Ulf, Lidholt, Kerstin

“…Hereditary multiple exostoses, characterized by multiple cartilaginous tumors, is ascribed to mutations at three distinct loci, denoted EXT1–3. Here, we report…”
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