Search Results - "Lindahl, Emma"
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Circular production operations – A management system's framework for seamless transition from linear to circular
Published in Cleaner environmental systems (01-06-2024)“…Production companies’ ambition to reach sustainable development goals, has resulted in a rapid strategic movement towards circularity in production. Previous…”
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α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice
Published in Scientific reports (24-11-2020)“…Type 2 diabetes (T2D), alike Parkinson’s disease (PD), belongs to the group of protein misfolding diseases (PMDs), which share aggregation of misfolded…”
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A framework on circular production principles and a way to operationalise circularity in production industry
Published in Cleaner Production Letters (01-06-2023)“…In the context of increasing pressure for sustainable production practices, this paper proposes a framework for how production companies could operationalise…”
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An allelic series of Trp63 mutations defines TAp63 as a modifier of EEC syndrome
Published in American journal of medical genetics. Part A (01-08-2013)“…Human Ectrodactyly, Ectodermal dysplasia, Clefting (EEC) syndrome is an autosomal dominant developmental disorder defined by limb deformities, skin defects,…”
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Proinsulin C-peptide Regulates Ribosomal RNA Expression
Published in The Journal of biological chemistry (29-01-2010)“…Proinsulin C-peptide is internalized into cells, but a function of its intracellular localization has not been established. We now demonstrate that, upon…”
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A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias
Published in The Journal of clinical investigation (01-05-2010)“…The human congenital syndromes ectrodactyly ectodermal dysplasia-cleft lip/palate syndrome, ankyloblepharon ectodermal dysplasia clefting, and split-hand/foot…”
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Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism
Published in PloS one (08-05-2015)“…Mice lacking ALK activity have previously been reported to exhibit subtle behavioral phenotypes. In this study of ALK of loss of function mice we present data…”
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Structural features of proinsulin C-peptide oligomeric and amyloid states
Published in The FEBS journal (01-09-2010)“…The formation and structure of proinsulin C-peptide oligomers has been investigated by PAGE, NMR spectroscopy and dynamic light scattering. The results…”
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Structural characterization of lipid A from nontypeable and type f Haemophilus influenzae: Variability of fatty acid substitution
Published in Analytical biochemistry (15-05-2005)“…Lipid A isolated by mild acid hydrolysis from lipopolysaccharides of 22 nontypeable and 2 type f Haemophilus influenzae strains was investigated using…”
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Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner
Published in Scientific reports (31-07-2015)“…The insulin-degrading enzyme (IDE) degrades amyloidogenic proteins such as Amyloid β (Αβ) and Islet Amyloid Polypeptide (IAPP), i.e. peptides associated with…”
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ΔNp63α Is an Oncogene that Targets Chromatin Remodeler Lsh to Drive Skin Stem Cell Proliferation and Tumorigenesis
Published in Cell stem cell (04-02-2011)“…The p53 homolog p63 is essential for development, yet its role in cancer is not clear. We discovered that p63 deficiency evokes the tumor-suppressive mechanism…”
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PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients
Published in JCI insight (21-06-2018)“…AMPK activated protein kinase (AMPK), a master regulator of energy homeostasis, is activated in response to an energy shortage imposed by physical activity and…”
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ΔNp73β puts the brakes on DNA repair
Published in Genes & development (15-03-2010)“…Mammalian cells are barraged with endogenous metabolic byproducts and environmental insults that can lead to nearly a million genomic lesions per cell per day…”
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ΔNp73β puts the brakes on DNA repair: Figure 1
Published in Genes & development (15-03-2010)“…Mammalian cells are barraged with endogenous metabolic byproducts and environmental insults that can lead to nearly a million genomic lesions per cell per day…”
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15
Proinsulin C-peptide regulates ribosomal RNA expression
Published in The Journal of biological chemistry (10-03-2017)Get full text
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Proinsulin C-peptide interaction with protein tyrosine phosphatase 1B demonstrated with a labeling reaction
Published in Biochemical and biophysical research communications (11-09-2009)“…Based on nickel-catalyzed cross-labeling where binding partners become biotinylated, we have studied molecular interactions with an N-terminally fused GGH-tag…”
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The membrane-induced structure of melittin is correlated with the fluidity of the lipids
Published in Biochimica et biophysica acta (2007)“…The effect of the bee toxin melittin on DMPC dynamics in fast-tumbling bicelles has been investigated. The 13C R 1 and 13C– 1H NOE relaxation parameters for…”
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Oligomerization and insulin interactions of proinsulin C-peptide: Threefold relationships to properties of insulin
Published in Biochemical and biophysical research communications (2010)“…Three principally different sites of action have been reported for proinsulin C-peptide, at surface-mediated, intracellular, and extracellular locations…”
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19
Insulin-degrading enzyme prevents [alpha]-synuclein fibril formation in a nonproteolytical manner
Published in Scientific reports (01-07-2015)“…The insulin-degrading enzyme (IDE) degrades amyloidogenic proteins such as Amyloid β (Αβ) and Islet Amyloid Polypeptide (IAPP), i.e. peptides associated with…”
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Journal Article -
20
ΔNp63α is an oncogene that induces Lsh expression and promotes stem-like proliferation
Published in Cell stem cell (04-02-2011)“…The p53 homolog p63 is essential for development, yet its role in cancer is not clear. We discovered that p63 deficiency evokes the tumor suppressive mechanism…”
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