Search Results - "Linda Wicker"

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial by Todd, John A, Evangelou, Marina, Cutler, Antony J, Pekalski, Marcin L, Walker, Neil M, Stevens, Helen E, Porter, Linsey, Smyth, Deborah J, Rainbow, Daniel B, Ferreira, Ricardo C, Esposito, Laura, Hunter, Kara M D, Loudon, Kevin, Irons, Kathryn, Yang, Jennie H, Bell, Charles J M, Schuilenburg, Helen, Heywood, James, Challis, Ben, Neupane, Sankalpa, Clarke, Pamela, Coleman, Gillian, Dawson, Sarah, Goymer, Donna, Anselmiova, Katerina, Kennet, Jane, Brown, Judy, Caddy, Sarah L, Lu, Jia, Greatorex, Jane, Goodfellow, Ian, Wallace, Chris, Tree, Tim I, Evans, Mark, Mander, Adrian P, Bond, Simon, Wicker, Linda S, Waldron-Lynch, Frank

“…Interleukin-2 (IL-2) has an essential role in the expansion and function of CD4+ regulatory T cells (Tregs). Tregs reduce tissue damage by limiting the immune…”
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A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease by Peterson, Laurence B., Bell, Charles J.M., Howlett, Sarah K., Pekalski, Marcin L., Brady, Kevin, Hinton, Heather, Sauter, Denise, Todd, John A., Umana, Pablo, Ast, Oliver, Waldhauer, Inja, Freimoser-Grundschober, Anne, Moessner, Ekkehard, Klein, Christian, Hosse, Ralf J., Wicker, Linda S.

“…Susceptibility to multiple autoimmune diseases is associated with common gene polymorphisms influencing IL-2 signaling and Treg function, making Treg-specific…”
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Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells by Inshaw, Jamie R J, Cutler, Antony J, Crouch, Daniel J M, Wicker, Linda S, Todd, John A

“…Immunohistological analyses of pancreata from patients with type 1 diabetes suggest distinct autoimmune islet β-cell pathology between those diagnosed at <7…”
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Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes by Robertson, Catherine C., Inshaw, Jamie R. J., Onengut-Gumuscu, Suna, Chen, Wei-Min, Santa Cruz, David Flores, Yang, Hanzhi, Cutler, Antony J., Crouch, Daniel J. M., Farber, Emily, Bridges, S. Louis, Edberg, Jeffrey C., Kimberly, Robert P., Buckner, Jane H., Deloukas, Panos, Divers, Jasmin, Dabelea, Dana, Lawrence, Jean M., Marcovina, Santica, Shah, Amy S., Greenbaum, Carla J., Atkinson, Mark A., Gregersen, Peter K., Oksenberg, Jorge R., Pociot, Flemming, Rewers, Marian J., Steck, Andrea K., Dunger, David B., Wicker, Linda S., Concannon, Patrick, Todd, John A., Rich, Stephen S.

“…We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date (61,427 participants), yielding 78 genome-wide-significant ( P  < 5 × 10…”
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Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes by Kochupurakkal, Nora M, Kruger, Annie J, Tripathi, Sudipta, Zhu, Bing, Adams, La Tonya, Rainbow, Daniel B, Rossini, Aldo, Greiner, Dale L, Sayegh, Mohamed H, Wicker, Linda S, Guleria, Indira

“…Inhibition of PD1-PDL1 signaling in NOD mice accelerates onset of type 1 diabetes implicating this pathway in suppressing the emergence of pancreatic beta cell…”
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Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis by Trzupek, Dominik, Dunstan, Melanie, Cutler, Antony J, Lee, Mercede, Godfrey, Leila, Jarvis, Lorna, Rainbow, Daniel B, Aschenbrenner, Dominik, Jones, Joanne L, Uhlig, Holm H, Wicker, Linda S, Todd, John A, Ferreira, Ricardo C

“…Traditionally, the transcriptomic and proteomic characterisation of CD4 T cells at the single-cell level has been performed by two largely exclusive types of…”
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Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases by Asimit, Jennifer L., Rainbow, Daniel B., Fortune, Mary D., Grinberg, Nastasiya F., Wicker, Linda S., Wallace, Chris

“…Thousands of genetic variants are associated with human disease risk, but linkage disequilibrium (LD) hinders fine-mapping the causal variants. Both lack of…”
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Chromosome contacts in activated T cells identify autoimmune disease candidate genes by Burren, Oliver S, Rubio García, Arcadio, Javierre, Biola-Maria, Rainbow, Daniel B, Cairns, Jonathan, Cooper, Nicholas J, Lambourne, John J, Schofield, Ellen, Castro Dopico, Xaquin, Ferreira, Ricardo C, Coulson, Richard, Burden, Frances, Rowlston, Sophia P, Downes, Kate, Wingett, Steven W, Frontini, Mattia, Ouwehand, Willem H, Fraser, Peter, Spivakov, Mikhail, Todd, John A, Wicker, Linda S, Cutler, Antony J, Wallace, Chris

“…Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4 T cells. Linking such regulatory…”
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Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping by Wallace, Chris, Cutler, Antony J, Pontikos, Nikolas, Pekalski, Marcin L, Burren, Oliver S, Cooper, Jason D, García, Arcadio Rubio, Ferreira, Ricardo C, Guo, Hui, Walker, Neil M, Smyth, Deborah J, Rich, Stephen S, Onengut-Gumuscu, Suna, Sawcer, Stephen J, Ban, Maria, Richardson, Sylvia, Todd, John A, Wicker, Linda S

“…Identification of candidate causal variants in regions associated with risk of common diseases is complicated by linkage disequilibrium (LD) and multiple…”
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The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults by Marcovecchio, M. Loredana, Hendriks, A. Emile J., Delfin, Carl, Battelino, Tadej, Danne, Thomas, Evans, Mark L., Johannesen, Jesper, Kaur, Simranjeet, Knip, Mikael, Overbergh, Lut, Pociot, Flemming, Todd, John A., Van der Schueren, Bart, Wicker, Linda S., Peakman, Mark, Mathieu, Chantal

“…Aims/hypothesis Type 1 diabetes is an heterogenous condition. Characterising factors explaining differences in an individual’s clinical course and treatment…”
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IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients by Ferreira, Ricardo C., Simons, Henry Z., Thompson, Whitney S., Cutler, Antony J., Dopico, Xaquin Castro, Smyth, Deborah J., Mashar, Meghavi, Schuilenburg, Helen, Walker, Neil M., Dunger, David B., Wallace, Chris, Todd, John A., Wicker, Linda S., Pekalski, Marcin L.

“…Aims/hypothesis Type 1 diabetes results from the autoimmune destruction of insulin-secreting pancreatic beta cells by T cells. Despite the established role of…”
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SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile by Zhang, Jia-Yuan, Whalley, Justin P, Knight, Julian C, Wicker, Linda S, Todd, John A, Ferreira, Ricardo C

“…Background The immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in COVID-19 patients has been extensively…”
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Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice by Mattner, Jochen, Mohammed, Javid P, Fusakio, Michael E, Giessler, Claudia, Hackstein, Carl-Philipp, Opoka, Robert, Wrage, Marius, Schey, Regina, Clark, Jan, Fraser, Heather I, Rainbow, Daniel B, Wicker, Linda S

“…Type 1 diabetes (T1D) is a chronic multi-factorial disorder characterized by the immune-mediated destruction of insulin-producing pancreatic beta cells…”
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Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes by Zhang, Jia-Yuan, Hamey, Fiona, Trzupek, Dominik, Mickunas, Marius, Lee, Mercede, Godfrey, Leila, Yang, Jennie H. M., Pekalski, Marcin L., Kennet, Jane, Waldron-Lynch, Frank, Evans, Mark L., Tree, Timothy I. M., Wicker, Linda S., Todd, John A., Ferreira, Ricardo C.

“…Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here we examine the…”
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Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes by Bailey, Rebecca, Smyth, Deborah J, Atkinson, Mark, Plagnol, Vincent, Brusko, Todd, Lowe, Christopher E, Field, Sarah, Wicker, Linda S, Bourget, Kirsi, Walker, Neil M, Todd, John A, Clayton, David G, Cooper, Jason D

“…Genome-wide association studies are now identifying disease-associated chromosome regions. However, even after convincing replication, the localization of the…”
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The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus by Oliveira, João J, Karrar, Sarah, Rainbow, Daniel B, Pinder, Christopher L, Clarke, Pamela, Rubio García, Arcadio, Al-Assar, Osama, Burling, Keith, Morris, Sian, Stratton, Richard, Vyse, Tim J, Wicker, Linda S, Todd, John A, Ferreira, Ricardo C

“…The molecular heterogeneity of autoimmune and inflammatory diseases has been one of the main obstacles to the development of safe and specific therapeutic…”
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Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity by Ferreira, Ricardo C., Simons, Henry Z., Thompson, Whitney S., Rainbow, Daniel B., Yang, Xin, Cutler, Antony J., Oliveira, Joao, Castro Dopico, Xaquin, Smyth, Deborah J., Savinykh, Natalia, Mashar, Meghavi, Vyse, Tim J., Dunger, David B., Baxendale, Helen, Chandra, Anita, Wallace, Chris, Todd, John A., Wicker, Linda S., Pekalski, Marcin L.

“…Identification of alterations in the cellular composition of the human immune system is key to understanding the autoimmune process. Recently, a subset of…”
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PTPN22 alters the development of regulatory T cells in the thymus by Maine, Christian J, Hamilton-Williams, Emma E, Cheung, Jocelyn, Stanford, Stephanie M, Bottini, Nunzio, Wicker, Linda S, Sherman, Linda A

“…PTPN22 encodes a tyrosine phosphatase that inhibits Src-family kinases responsible for Ag receptor signaling in lymphocytes and is strongly linked with…”
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Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function by Garg, Garima, Tyler, Jennifer R, Yang, Jennie H M, Cutler, Antony J, Downes, Kate, Pekalski, Marcin, Bell, Gwynneth L, Nutland, Sarah, Peakman, Mark, Todd, John A, Wicker, Linda S, Tree, Timothy I M

“…Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1…”
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The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function by GEROLD, Kay D, PEILIN ZHENG, RAINBOW, Daniel B, ZERNECKE, Alma, WICKER, Linda S, KISSLER, Stephan

“…CTLA4 gene variation associates with multiple autoimmune disorders, including type 1 diabetes. The CTLA4 susceptibility allele was found to generate decreased…”
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