Search Results - "Linda Pluta"

Whole-genome sequencing of Kaposi sarcoma-associated herpesvirus (KSHV/HHV8) reveals evidence for two African lineages by Moorad, Razia, Juarez, Angelica, Landis, Justin T., Pluta, Linda J., Perkins, Megan, Cheves, Avery, Dittmer, Dirk P.

“…Kaposi sarcoma (KS)-associated herpesvirus (KSHV/HHV-8) was first sequenced from the body cavity (BC) lymphoma cell line, BC-1, in 1996. Few other KSHV genomes…”
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A prospective cohort study identifies two types of HIV+ Kaposi Sarcoma lesions: proliferative and inflammatory by Moorad, Razia, Kasonkanji, Edwards, Gumulira, Joe, Gondwe, Yolanda, Dewey, Morgan, Pan, Yue, Peng, Alice, Pluta, Linda J, Kudowa, Evaristar, Nyasosela, Richard, Tomoka, Tamiwe, Tweya, Hannock, Heller, Tom, Gugsa, Salem, Phiri, Sam, Moore, Dominic T, Damania, Blossom, Painschab, Matthew, Hosseinipour, Mina C, Dittmer, Dirk P

“…Kaposi sarcoma (KS) is the most common cancer in people living with HIV (PLWH) in many countries where KS-associated herpesvirus is endemic. Treatment has…”
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High-Density Amplicon Sequencing Identifies Community Spread and Ongoing Evolution of SARS-CoV-2 in the Southern United States by McNamara, Ryan P., Caro-Vegas, Carolina, Landis, Justin T., Moorad, Razia, Pluta, Linda J., Eason, Anthony B., Thompson, Cecilia, Bailey, Aubrey, Villamor, Femi Cleola S., Lange, Philip T., Wong, Jason P., Seltzer, Tischan, Seltzer, Jedediah, Zhou, Yijun, Vahrson, Wolfgang, Juarez, Angelica, Meyo, James O., Calabre, Tiphaine, Broussard, Grant, Rivera-Soto, Ricardo, Chappell, Danielle L., Baric, Ralph S., Damania, Blossom, Miller, Melissa B., Dittmer, Dirk P.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is constantly evolving. Prior studies focused on high-case-density locations, such as the northern…”
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Endosomal TLR-8 Senses microRNA-1294 Resulting in the Production of NFḱB Dependent Cytokines by Pluta, Linda, Yousefi, Babak, Damania, Blossom, Khan, Asma A

“…The primary function of toll-like receptor 8 (TLR-8) is the detection of viruses and other microbial pathogens. Recent evidence suggests that TLR-8 also senses…”
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Intra-Host Evolution Provides for the Continuous Emergence of SARS-CoV-2 Variants by Landis, Justin T, Moorad, Razia, Pluta, Linda J, Caro-Vegas, Carolina, McNamara, Ryan P, Eason, Anthony B, Bailey, Aubrey, Villamor, Femi Cleola S, Juarez, Angelica, Wong, Jason P, Yang, Brian, Broussard, Grant S, Damania, Blossom, Dittmer, Dirk P

“…Variants of concern (VOC) in SARS-CoV-2 refer to viruses whose viral genomes differ from the ancestor virus by ≥3 single-nucleotide variants (SNVs) and that…”
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A prospective study of asymptomatic SARS-CoV-2 infection among individuals involved in academic research under limited operations during the COVID-19 pandemic by Pettifor, Audrey, DiPrete, Bethany L, Shook-Sa, Bonnie E, Premkumar, Lakshmanane, Kuczynski, Kriste, Dittmer, Dirk, Aiello, Allison, Wallet, Shannon, Maile, Robert, Tan, Joyce, Jadi, Ramesh, Pluta, Linda, de Silva, Aravinda M, Weber, David J, Kim, Min, Seña, Arlene C, Jones, Corbin D

“…Early in the pandemic, transmission risk from asymptomatic infection was unclear, making it imperative to monitor infection in workplace settings. Further,…”
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MYC is an early response regulator of human adipogenesis in adipose stem cells by Deisenroth, Chad, Black, Michael B, Pendse, Salil, Pluta, Linda, Witherspoon, Sam M, McMullen, Patrick D, Thomas, Russell S

“…Adipose stem cell (ASC) differentiation is necessary for the proper maintenance and function of adipose tissue. The procurement and characterization of…”
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Application of Genomic Biomarkers to Predict Increased Lung Tumor Incidence in 2-Year Rodent Cancer Bioassays by Thomas, Russell S., Pluta, Linda, Yang, Longlong, Halsey, Thomas A.

“…Rodent cancer bioassays are part of a legacy of safety testing that has not changed significantly over the past 30 years. The bioassays are expensive, time…”
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Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages by Woods, Courtney G., Fu, Jingqi, Xue, Peng, Hou, Yongyong, Pluta, Linda J., Yang, Longlong, Zhang, Qiang, Thomas, Russell S., Andersen, Melvin E., Pi, Jingbo

“…Hypochlorous acid (HOCl) is potentially an important source of cellular oxidative stress. Human HOCl exposure can occur from chlorine gas inhalation or from…”
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Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis by Ingram, Jennifer L, Antao-Menezes, Aurita, Turpin, Elizabeth A, Wallace, Duncan G, Mangum, James B, Pluta, Linda J, Thomas, Russell S, Bonner, James C

“…Exposure to vanadium pentoxide (V2O5) is a cause of occupational bronchitis. We evaluated gene expression profiles in cultured human lung fibroblasts exposed…”
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Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival by Page, Todd J, Sikder, Devanjan, Yang, Longlong, Pluta, Linda, Wolfinger, Russell D, Kodadek, Thomas, Thomas, Russell S

“…Although HSF1 plays an important role in the cellular response to proteotoxic stressors, little is known about the structure and function of the human HSF1…”
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Subchronic hepatotoxicity evaluation of bromobenzene in Fischer 344 rats by Dodd, Darol E., Pluta, Linda J., Sochaski, Mark A., Banas, Deborah A., Thomas, Russell S.

“…ABSTRACT Male Fischer 344 (F344) rats were exposed to bromobenzene (BB) for 5 days and 2, 4 and 13 weeks. BB was administered by gavage (corn oil vehicle) at…”
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Subchronic urinary bladder toxicity evaluation of N-Nitrosodiphenylamine in Fischer 344 rats by Dodd, Darol E., Pluta, Linda J., Sochaski, Mark A., Funk, Kathleen A., Thomas, Russell S.

“…ABSTRACT Female Fischer 344 (F344) rats were exposed to N‐nitrosodiphenylamine (NDPA) by dietary feed at concentrations of 0, 250, 1000, 2000, 3000 or 4000 ppm…”
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A Comparison of Transcriptomic and Metabonomic Technologies for Identifying Biomarkers Predictive of Two-Year Rodent Cancer Bioassays by Thomas, Russell S., O'Connell, Thomas M., Pluta, Linda, Wolfinger, Russell D., Yang, Longlong, Page, Todd J.

“…Two-year rodent bioassays play a central role in evaluating the carcinogenic potential of both commercial products and environmental contaminants. The…”
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Subchronic Thyroid Toxicity Evaluation of 4,4′-Methylenebis(N,N′-Dimethyl)Aniline in Fischer 344 Rats by Dodd, Darol E., Pluta, Linda J., Sochaski, Mark A., Funk, Kathleen A., Thomas, Russell S.

“…Female F344 rats were exposed to 4,4′-methylenebis(N,N′-dimethyl)aniline (MDA) by dietary feed at concentrations of 0, 50, 200, 375, 500, or 750 ppm for 5 d, 2…”
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Subchronic Hepatotoxicity Evaluation of Hydrazobenzene in Fischer 344 Rats by Dodd, Darol E., Pluta, Linda J., Sochaski, Mark A., Wall, Henry G., Thomas, Russell S.

“…Male F344 rats were exposed to hydrazobenzene (HZB) by dietary feed at concentrations of 0, 5, 20, 80, 200, or 300 ppm for 5 days, 2 weeks, 4 weeks, or 13…”
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Subchronic Hepatotoxicity Evaluation of 1,2,4-Tribromobenzene in Sprague-Dawley Rats by Dodd, Darol E., Pluta, Linda J., Sochaski, Mark A., Funk, Kathleen A., Thomas, Russell S.

“…Male Sprague-Dawley rats were exposed to 1,2,4-tribromobenzene (TBB) by gavage for 5 days, 2, 4, and 13 weeks at 0, 2.5, 5, 10, 25, or 75 mg/kg per d. There…”
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Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1 by Bauer, Alison K, Faiola, Brenda, Abernethy, Diane J, Marchan, Rosemarie, Pluta, Linda J, Wong, Vicki A, Roberts, Kay, Jaiswal, Anil K, Gonzalez, Frank J, Butterworth, Byron E, Borghoff, Susan, Parkinson, Horace, Everitt, Jeffrey, Recio, Leslie

“…Enzymes that activate and detoxify benzene are likely genetic determinants of benzene-induced toxicity.NAD(P)H: quinone oxidoreductase-1 (NQO1) detoxifies…”
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Subchronic Hepatotoxicity Evaluation of 2,3,4,6-Tetrachlorophenol in Sprague Dawley Rats by Dodd, Darol E., Pluta, Linda J., Sochaski, Mark A., Banas, Deborah A., Thomas, Russell S.

“…Male Sprague Dawley rats were exposed to 2,3,4,6-tetrachlorophenol (TCP) for 5 days, 2 weeks, 4 weeks, or 13 weeks. TCP was administered by gavage at doses of…”
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Exposure of Hematopoietic Stem Cells to Benzene or 1,4‐Benzoquinone Induces Gender‐Specific Gene Expression by Faiola, Brenda, Fuller, Elizabeth S., Wong, Victoria A., Pluta, Linda, Abernethy, Diane J., Rose, Jason, Recio, Leslie

“…Chronic exposure to benzene results in progressive decline of hematopoietic function and may lead to the onset of various disorders, including aplastic anemia,…”
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