Intracranial compliance in type 2 diabetes mellitus and its relationship with the cardiovascular autonomic nervous control

Intracranial compliance in type 2 diabetes mellitus and its relationship with the cardiovascular autonomic nervous control

The intracranial compliance in type 2 diabetes mellitus (T2DM) patients and the association with cardiovascular autonomic control have not been fully elucidated. The aim of this study was to assess intracranial compliance using the noninvasive intracranial pressure (niICP) and the monitoring of wave...

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Published in:Brazilian journal of medical and biological research Vol. 55; no. 1; pp. 1 - e12150
Main Authors: Galdino, G.A.M, Moura-Tonello, S.C.G, Linares, S.N, Milan-Mattos, J.C, Spavieri, D.L., Jr, Oliveira, S.M, Porta, A, Beltrame, T, Catai, A.M
Format: Journal Article
Language:English
Published: Ribeirao Preto Associacao Brasileira de Divulgacao Cientifica (ABDC) 01-01-2022
Revista Brasileira de Pesquisas Medicas
Associação Brasileira de Divulgação Científica
Subjects:
Active postural change
Autonomic nervous system
Autonomic neuropathies
Baroreceptors
BIOLOGY
Blood pressure
Cardiovascular diseases
Cardiovascular modulation
Cardiovascular system
Cerebrovascular circulation
Compliance
Complications and side effects
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetic neuropathy
Diagnosis
EKG
Electrocardiogram
Electrocardiography
Health aspects
Intracranial pressure
Measurement
MEDICINE, RESEARCH & EXPERIMENTAL
Metabolic disease
Oscillations
Reflexes
Risk factors
Scalp
Type 2 diabetes
Brazil
Cerebrovascular circulation
Metabolic disease
Active postural change
Cardiovascular modulation
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Summary:The intracranial compliance in type 2 diabetes mellitus (T2DM) patients and the association with cardiovascular autonomic control have not been fully elucidated. The aim of this study was to assess intracranial compliance using the noninvasive intracranial pressure (niICP) and the monitoring of waveform peaks (P1, P2, and P3) and the relationship with cardiovascular autonomic control in T2DM patients. Thirty-two men aged 40-60 years without cardiovascular autonomic neuropathy (CAN) were studied: T2DMG (n=16) and control group CG (n=16). The niICP was evaluated by a noninvasive extracranial sensor placed on the scalp. Cardiovascular autonomic control was evaluated by indices of the baroreflex sensitivity (BRS), from temporal series of R-R intervals of electrocardiogram and systolic arterial pressure, during supine and orthostatic positions. The participants remained in the supine position for 15 min and then 15 min more in orthostatism. T2DMG presented a decrease of the P2/P1 ratio during the orthostatic position (P<0.001). There was a negative moderate correlation between the P2 peak with cardiovascular coupling ([K.sup.2.sub.HP-SAP]LF) in supine (r=-0.612, P=0.011) and orthostatic (r=-0.568, P=0.020) positions in T2DMG. We concluded that T2DM patients without CAN and cardiovascular complications presented intracranial compliance similar to healthy subjects. Despite preserved intracranial adjustments, T2DM patients had a response of greater magnitude in orthostatism. In addition, the decoupling between the heart period and blood pressure signal oscillations in low frequency appeared to be related to the worsening of intracranial compliance due to the increased P2 peak. Key words: Cardiovascular modulation; Active postural change; Cerebrovascular circulation; Metabolic disease
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ISSN:0100-879X
1414-431X
1414-431X
1678-4510
DOI:10.1590/1414-431X2022e12150